Navigation Links
Possible birthplace of malignant brain tumors identified

Researchers have found that abnormal stimulation of a cellular trigger that normally regulates replenishment of brain cells in adults causes invasive tumor-like growths in mice. Removing the abnormal stimulation causes the growths to regress--a finding the researchers said suggests a possible treatment for the lethal, aggressive brain tumors called malignant gliomas.

Arturo Alvarez-Buylla and Erica L. Jackson, of the University of California, San Francisco, and colleagues reported their findings in a paper in the July 20, 2006, Neuron, published by Cell Press. In their studies, they sought to discover whether neural stem cells in the brain called B cells carry a receptor--known as platelet-derived growth factor receptor á (PDGFRá)--for the signaling molecule PDGF.

Neural stem cells are immature cells that serve as the continual source of new brain cells in adults, and PDGF is known as an important regulator of such cells. Also, PDGF has been implicated as a key signaling molecule underlying the formation of brain tumors. PDGF triggers such cell response by plugging into the target receptor on the stem cell, like a key inserting into a lock.

There had been indirect evidence that neural stem cells give rise to brain tumors. "However, it has not been shown in vivo that tumor stem cells are derived from normal stem cells or that a specific population of cells with demonstrated stem cell properties is capable of initiating tumor formation," wrote the researchers.

Using tracers, the researchers discovered that PDGFRá is, indeed, found on the stem cells in both mouse and human brain tissue. They also found that the receptor is triggered by PDGF in the stem cells to regulate their production of mature brain cells. The researchers located the PDGFRá-containing cells in the subventricular zone (SVZ) of the brain, which is the center for production of new brain cells in adults.

The researchers also found that infusing PDGF into mous
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Stem Cells Found In Cerebellum; Possible Cell of Origin for Childhood Brain Tumors
2. Possible treatment found for chemobrain
3. Is it Possible to Change Prescribing Habits?
4. Possible brain hormone may unlock mystery of hibernation
5. Newfound roadblock to interferon effectiveness against malignant melanoma
6. Researchers discover why melanoma is so malignant
7. Stem cell microenvironment reverses malignant melanoma
8. Controversial drug shown to act on brain protein to cut alcohol use
9. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
10. Mouse brain tumors mimic those in human genetic disorder
11. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Possible birthplace malignant brain tumors identified

(Date:4/13/2015)... a leading cloud-based consumer engagement platform that provides trusted ... communities around health and wellness, announced today the launching ... The ... vehicle to receive validated health information from consumers. ... will allow higi,s trusted partners, on a user opt-in ...
(Date:4/8/2015)... 2015  Infinisource, a leading provider of SaaS-based Human ... a leading supplier of biometric identification and security ... most advanced biometrically-enabled time clock, the companies announced ... is setting a bold, new standard for the ... small and mid-size employer. When connected to the ...
(Date:4/2/2015)... , April 2, 2015 At its 2015 ... Lake City , the American College of Medical ... new directors to its Board.  Members of the ACMG ... and for forming and advancing its policies and programs. ... profession. "It,s an eventful time in medical ...
Breaking Biology News(10 mins):higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8
... 7, 2010) -- A tumor,s genetic profile is often ... cancers, but inexplicably, genetically similar leukemias in different patients ... Weill Cornell Medical College researchers believe they may have ... differences between patients with acute myeloid leukemia (AML). ...
... the University of Sheffield have scooped an international award in ... make the production of alternative biofuels more energy efficient. ... use in the production of alternative renewable fuels, to replace ... biofuels currently requires vast amounts of power and when the ...
... The earliest known domestic horses are around 4,600 years ... Ukraine and Kazakhstan. Using this evidence, two different hypotheses ... area over the rest of Eurasia; 2) horse domestication ... different local places. "Previous analysis on mitochondrial DNA ...
Cached Biology News:Researchers discover genetic differences between lethal and treatable forms of leukemia 2Scientists' breakthrough in production of biofuels 2Wild Iberian horses contributed to the origin of the current Iberian domestic stock 2
(Date:4/30/2015)... , April 30, 2015 The following is an ... Directors of China Cord Blood Corp (NYSE: CO ) ... committee of the independent directors of China Cord Blood Corp ... offer of $6.40 per share from Golden Meditech Holdings Co ... per share would greatly benefit Golden Med and Mr. Kam, ...
(Date:4/30/2015)... SAN DIEGO , April 30, 2015 /PRNewswire/ ... company engaged in the development of biosimilar therapeutics ... today announced the closing of its previously announced ... common stock at a public offering price of ... full by the underwriters of their option to ...
(Date:4/30/2015)... -- WuXi PharmaTech (Cayman) Inc. ("WuXi" or the "Company") ... services provider, today announced that its board of directors ... 29, 2015, from a consortium (the "Consortium") led by ... and chief executive officer of the Company, and Ally ... (the "Transaction") involving the acquisition of all outstanding shares ...
(Date:4/30/2015)... SureClinical, a leader in cloud-based health science ... SureClinical’s executive team as Chief Financial Officer. ... with over 25 years in leadership roles ranging from ... Morris joins SureClinical from Marrone Bio Innovations (MBI), a ... MBI from its founding in 2006 until 2011, when ...
Breaking Biology Technology:April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 2April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 3April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 4April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 5Pfenex Inc. Announces Closing of Public Offering of Common Stock and Full Exercise of Underwriters' Option to Purchase Additional Shares 2WuXi PharmaTech Announces Receipt of Proposal 2WuXi PharmaTech Announces Receipt of Proposal 3WuXi PharmaTech Announces Receipt of Proposal 4WuXi PharmaTech Announces Receipt of Proposal 5WuXi PharmaTech Announces Receipt of Proposal 6Julie I. Morris Joins SureClinical as Chief Financial Officer 2
... Inc. (Nasdaq: ONXX ) today announced that ... Forum on Wednesday,October 10 at 11:15 a.m. Pacific ... the presentation at:, http://www.corporate-ir.net/ireye/confLobby.zhtml?ticker=ONXX&item_id=1657737 It ... early in order to,register and download any necessary ...
... Pharmaceuticals,Inc. (Nasdaq: CADX ), a biopharmaceutical company ... principally,for use in the hospital setting, announced today ... present the corporate overview on,Wednesday, October 10, 2007 ... Time),during the BIO Investor Forum in San Francisco. ...
... 3 /PRNewswire-FirstCall/ - Dr. Brad Thompson, President,and CEO ... will present a,corporate overview of the Company at ... on Tuesday, October 9 at 9 a.m. The ... Conference Centre from October 7-9,2007. About Oncolytics ...
Cached Biology Technology:Cadence Pharmaceuticals' CEO Theodore Schroeder to Present at BIO Investor Forum 2Media Advisory - Oncolytics Biotech Inc. to Present at BioPartnering Europe 2
... marking pen has been designed to provide a thin ... specimen on a slide. This barrier creates the ... the target area on the slide. PAP Pen ... and acetone. It can be removed, if desired, ...
Mouse monoclonal antibody to QDPR - quinoid dihydropteridine reductase...
...
Anti-Conjugated Quinaldic Acid...
Biology Products: