Navigation Links
Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

e needed to find out what was happening in these mice, before they got the problem."

Their insulin levels provided a clue. In the prenatally undernourished mice, the insulin secretion stayed about the same, regardless of the glucose level in the bloodstream. "That surprised us," Dr. Patti said. "The problem was not insulin resistance. It had something to do with insulin secretion." By contrast, babies who are born overweight (greater than 8 pounds) have higher risk of insulin resistance, not a secretion problem. Something different was happening in the experiment's low-birth-weight mice.

Did prenatal undernourishment cause the pancreas to not fully develop? The researchers found no difference in pancreas size or numbers of pancreatic beta cells, which produce insulin.

But cultures of the beta cells revealed the answer: the undernourished mice had an abnormal way of responding to glucose. "They were somehow 'programmed' to secrete a limited amount of insulin later in life, no matter what signal they got from glucose," Dr. Patti said. "The impairment was permanent. It couldn't be corrected even when the body caught up to normal weight."

Because studies of mice generally are good predictors of human biology, the Joslin study has important implications. "People and their doctors need to understand that prenatal undernourishment makes a person permanently at higher risk for developing diabetes, so prenatal care is important," Dr. Patti said. "Moreover, if someone was born with low weight, they need to pay special attention to prevention tactics, including exercise and weight control to minimize insulin resistance -- the other major factor involved in triggering type 2 diabetes.

"In particular, someone who was a low-birth-weight baby can compound the risk of developing diabetes by becoming overweight," she added. "The stage is set in two ways: low insulin production coupled with resistance to insulin -- a double whammy."

Oth
'"/>

Source:Joslin Diabetes Center


Page: 1 2 3 4

Related biology news :

1. PET/MRI scans may help unravel mechanisms of prenatal drug damage
2. Study finds that nutritionally enhanced rice reduces iron deficiency
3. Mother birds give a nutritional leg up to chicks with unattractive fathers
4. Soil nutrition affects carbon sequestration in forests
5. Used in a new way, RNA interference permanently silences key breast cancer gene
6. Smoking damages key regulatory enzyme in the lung
7. Automatic extraction of gene/protein biological functions from biomedical text
8. New research questions basic tenet of neuron function
9. Vascular structure and function improve with diet and exercise
10. Towards precise classification of cancers based on robust gene functional expression profiles
11. Researchers reveal secret of key protein in brain and heart function
Post Your Comments:
(Date:4/15/2014)... researchers have previously shown that a genetic pre-disposition to ... a new study, Frank Booth, a professor in the ... link between the genetic pre-disposition for high levels of ... occurs. , For his study, Booth selectively bred rats ... laziness. Booth then put the rats in cages with ...
(Date:4/15/2014)... Western Reserve University dental researchers have found a ... cells from the mouth to study how the ... , By isolating some specialized immune cells (white ... they fight diseases in the mouthor reject foreign ... to learn more about treating and preventing such ...
(Date:4/15/2014)... There are many viral diseases in the world for ... dengue fever, which is spread by mosquitoes in the ... is more familiar in Finland and is easily spread ... small children and the elderly. , Researchers at Aalto ... succeeded in preliminary tests to prevent the spread of ...
Breaking Biology News(10 mins):Genetic pre-disposition toward exercise and mental development may be linked 2New method isolates immune cells for researchers to study how they ward off oral diseases 2Nanocrystalline cellulose modified into an efficient viral inhibitor 2
... University of California, San Diego School of Medicine say that ... molecule boosted disease protection in early hominids, and may have ... Homo . The findings, published in this week,s early ... of Sciences , are among the first evidence of a ...
... Research by biologists at the University of York and ... about the way the brain is affected by age. ... Medicine and Dentistry in Plymouth, they have studied responses ... The researchers discovered that under stressful conditions, such as ...
... off to Antarctica for the first stage of an ambitious ... lake buried beneath three kilometres of solid ice. This extraordinary ... knowledge about the evolution of life on Earth and other ... climate. Transporting nearly 70 tonnes of equipment the ,advance ...
Cached Biology News:Sexual selection by sugar molecule helped determine human origins 2Sexual selection by sugar molecule helped determine human origins 3Researchers study aging's effect on the brain 2Engineering team heads to Antarctica to explore hidden lake 2Engineering team heads to Antarctica to explore hidden lake 3
(Date:1/15/2014)... 2014 2013 was a banner ... Brain State Technologies®. They saw continued independent research ... Medical Center who were awarded a $1 million ... research papers published in “Brain and Behavior” a ... in First for Women Magazine and they were ...
(Date:1/14/2014)... 2014 Carahsoft and CDS Federal ... January 23, 2014 at 2pm EST (11am PST), ... Knowledge.” The topic focuses on how technology can ... drive mission critical decisions for government agencies. The ... Synopsis: Big Data has become an obstacle for ...
(Date:1/14/2014)... Texas , Jan. 14, 2014 ... analyze and research medicinal plants and therapeutic derivatives ... industry, health professionals, and researchers about the challenges ... (Logo: http://photos.prnewswire.com/prnh/20100430/DC95601LOGO ) The ... (known by its acronym GA, based on ...
(Date:1/14/2014)... 2014 Global Record Systems, LLC, ... technology solutions for patients, physicians, the biopharmaceutical industry, ... today the signing of a three-year Research Collaboration ... Administration (FDA). This initiative is designed to ... safety, clinical outcomes, and medication adherence. , It ...
Breaking Biology Technology:Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2
COMING SOON: Anti-Mouse C5/C5b, Clone BB5.1. Monoclonal Antibody...
... Goat anti-Human Alpha 1 Acid ... azide Goats were immunized ... glycoprotein in Freund's adjuvant. ... absorbed to ensure specificity. ...
Anti-Mouse Valpha 2 TCR, Purified (Clone B20.1) (rat IgG2a)...
Request Info...
Biology Products: