Navigation Links
Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

e needed to find out what was happening in these mice, before they got the problem."

Their insulin levels provided a clue. In the prenatally undernourished mice, the insulin secretion stayed about the same, regardless of the glucose level in the bloodstream. "That surprised us," Dr. Patti said. "The problem was not insulin resistance. It had something to do with insulin secretion." By contrast, babies who are born overweight (greater than 8 pounds) have higher risk of insulin resistance, not a secretion problem. Something different was happening in the experiment's low-birth-weight mice.

Did prenatal undernourishment cause the pancreas to not fully develop? The researchers found no difference in pancreas size or numbers of pancreatic beta cells, which produce insulin.

But cultures of the beta cells revealed the answer: the undernourished mice had an abnormal way of responding to glucose. "They were somehow 'programmed' to secrete a limited amount of insulin later in life, no matter what signal they got from glucose," Dr. Patti said. "The impairment was permanent. It couldn't be corrected even when the body caught up to normal weight."

Because studies of mice generally are good predictors of human biology, the Joslin study has important implications. "People and their doctors need to understand that prenatal undernourishment makes a person permanently at higher risk for developing diabetes, so prenatal care is important," Dr. Patti said. "Moreover, if someone was born with low weight, they need to pay special attention to prevention tactics, including exercise and weight control to minimize insulin resistance -- the other major factor involved in triggering type 2 diabetes.

"In particular, someone who was a low-birth-weight baby can compound the risk of developing diabetes by becoming overweight," she added. "The stage is set in two ways: low insulin production coupled with resistance to insulin -- a double whammy."

Oth
'"/>

Source:Joslin Diabetes Center


Page: 1 2 3 4

Related biology news :

1. PET/MRI scans may help unravel mechanisms of prenatal drug damage
2. Study finds that nutritionally enhanced rice reduces iron deficiency
3. Mother birds give a nutritional leg up to chicks with unattractive fathers
4. Soil nutrition affects carbon sequestration in forests
5. Used in a new way, RNA interference permanently silences key breast cancer gene
6. Smoking damages key regulatory enzyme in the lung
7. Automatic extraction of gene/protein biological functions from biomedical text
8. New research questions basic tenet of neuron function
9. Vascular structure and function improve with diet and exercise
10. Towards precise classification of cancers based on robust gene functional expression profiles
11. Researchers reveal secret of key protein in brain and heart function
Post Your Comments:
(Date:12/10/2014)... , Dec. 08, 2014 Research and Markets ... addition of the "Biometrics Market in Japan ... http://photos.prnewswire.com/prnh/20130307/600769 The ... such as rural banking and upgradation of the ... witnessed in the market. Besides the aforementioned projects, ...
(Date:12/5/2014)... , Dec. 4, 2014  Tute Genomics, a leader ... million in Series A1 funding led by UK-based Eurovestech. ... participated in the investment round. "We are ... community adopts next-generation sequencing and seeks new approaches for ... Reid Robison , MD MBA, and CEO of Tute ...
(Date:12/3/2014)... 2, 2014 As part of our commitment ... is pleased to announce the release of a new ... collect the workforce data that they need. ... left by existing readers. Many such devices have serious ... modern technology. Older models force users to navigate numerous ...
Breaking Biology News(10 mins):Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Inception Technologies to Release New Biometric Reader 2
... A major step in commercializing the groundbreaking research ... University of Minnesota signed an exclusive, global license agreement ... worldwide attention in 2008 when her team announced that ... laboratory. The technology licensed to Miromatrix holds the ...
... Calif., Feb. 16, 2010 Butterfly experts have suspected for ... in explaining wing color diversity. Now, for the first time, ... at least in nine Heliconius species. ... ultraviolet colors also have UV-yellow pigment on their wings, reports ...
... coastal fog has decreased significantly over the past 100 years, ... according to a new study by University of California, Berkeley, ... a natural cycle of the result of human activity, but ... entire redwood ecosystem, the scientists say. , "Since 1901, the ...
Cached Biology News:U of Minnesota finalizes license agreement to form start-up company based on Doris Taylor research 2Butterfly vision, wing colors linked, UCI study finds 2Fog has declined in past century along California's redwood coast 2Fog has declined in past century along California's redwood coast 3Fog has declined in past century along California's redwood coast 4
(Date:12/24/2014)... Pipette.com announces their Holiday in the ... their #HolidayInTheLab pictures for a chance to win pipette-themed ... those struggling to think of a holiday gift for ... Lab Contest provides the ideal holiday presents. The #HolidayInTheLab ... pictures of their chemistree, holiday sweaters, as well as ...
(Date:12/24/2014)... Fla. , Dec. 23, 2014  Rock Creek ... that it has filed a Clinical Trial Application (CTA) ... Healthcare products Regulatory Agency (MHRA) seeking regulatory approval to ... lead molecule, Anatabine Citrate. Contingent on the ... conduct a Phase I trial to assess the safety, ...
(Date:12/22/2014)... CHAPEL HILL, N.C. , Dec. 22, 2014 ... ALNE) today announced that it has signed a ... biotechnology company that has developed and patented a ... and medical diagnostics products that enable rapid on-site ... and alcohol use/abuse and health issues in an ...
(Date:12/22/2014)... TENN (PRWEB) December 22, 2014 Fertility ... Donor Egg Bank USA , a network of ... country. Through this partnership, patients have fast access to ... in vitro fertilization, IVF . Fertility Associates of Memphis ... offer this fertility treatment option. , Dr. William ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3ALNE Announces Intention To Acquire BioTechPharma 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3
... to Host Conference Call at 12:30 p.m. Eastern Time, September 19, ... ... Sept. 19 Indevus,Pharmaceuticals, Inc. (Nasdaq: IDEV ) today announced that ... obtained the,United States rights to SANCTURA(R) and SANCTURA(R) XR. In connection with,Allergan,s ...
... Corporation,(Nasdaq: CRGN ), a clinical-stage biopharmaceutical company ... M.D., has been appointed,President and Chief Executive Officer, ... remain with the Company through the end,of 2007, ... on CuraGen,s,Board of Directors until the Annual Stockholders ...
... for ... inflammatory bowel disease., OKLAHOMA CITY, Sept. 18 Altheus Therapeutics, ... trials,testing the efficacy of its therapy for the treatment of inflammatory ... by the,Oklahoma Seed Capital Fund and Oklahoma Equity Partners. About ...
Cached Biology Technology:Indevus Announces Allergan as New Partner for SANCTURA Brand 2Indevus Announces Allergan as New Partner for SANCTURA Brand 3Indevus Announces Allergan as New Partner for SANCTURA Brand 4Indevus Announces Allergan as New Partner for SANCTURA Brand 5Indevus Announces Allergan as New Partner for SANCTURA Brand 6CuraGen Corporation Announces Appointment of Dr. Timothy M. Shannon as President and Chief Executive Officer 2CuraGen Corporation Announces Appointment of Dr. Timothy M. Shannon as President and Chief Executive Officer 3CuraGen Corporation Announces Appointment of Dr. Timothy M. Shannon as President and Chief Executive Officer 4CuraGen Corporation Announces Appointment of Dr. Timothy M. Shannon as President and Chief Executive Officer 5Altheus Therapeutics Secures $3.6 Million in Venture Capital 2