Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas ( Scientists at Joslin Diabetes Center ha...)

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

Scientists at Joslin Diabetes Center have discovered one reason why infants with low birth weight have a high potential of developing type 2 diabetes later in life. In studies of mice, the researchers found that poor prenatal nutrition impairs the pancreas's ability to later secrete enough insulin in response to blood glucose.

"The bottom line is that if you don't have delivery of enough nutrients from the mother to the baby, the baby's pancreatic cells will be programmed abnormally," said principal investigator Mary-Elizabeth Patti, M.D., Assistant Investigator in Joslin's Research Section on Cellular and Molecular Physiology and Assistant Professor of Medicine at Harvard Medical School. "The effect doesn't show up until later on -- usually not until adolescence or adulthood.

"Many people believe we don't have much of a prenatal nourishment problem in the United States," she added. "But poor nutrition of a developing baby can occur in many ways other than inadequate nutrition of the mother. It also can occur with abnormal development of the placenta and its blood vessels, or high blood pressure, which damages vessels." In addition, many other factors can result in intrauterine growth restriction and low birth weight.

The Joslin study, published in the March edition of Diabetes, reinforces what scientists have known from previous studies in humans: Infants with low birth weight -- typically defined as under five and one-half pounds -- have a higher risk for developing type 2 diabetes.

To understand the reason, the researchers designed a series of experiments. Using ordinary mice that were not inbred or genetically altered in any way, they mated females with males, dating the day of their pregnancy, which lasts three weeks. They separated the mothers into two groups. The control group ate as much chow as they wanted during the entire pregnancy. The other group also was fully nourished during the first two weeks but undernourished during
'"/>

Source:Joslin Diabetes Center

Page: 1 2 3 4
Related biology news :

1. PET/MRI scans may help unravel mechanisms of prenatal drug damage
2. Study finds that nutritionally enhanced rice reduces iron deficiency
3. Mother birds give a nutritional leg up to chicks with unattractive fathers
4. Soil nutrition affects carbon sequestration in forests
5. Used in a new way, RNA interference permanently silences key breast cancer gene
6. Smoking damages key regulatory enzyme in the lung
7. Automatic extraction of gene/protein biological functions from biomedical text
8. New research questions basic tenet of neuron function
9. Vascular structure and function improve with diet and exercise
10. Towards precise classification of cancers based on robust gene functional expression profiles
11. Researchers reveal secret of key protein in brain and heart function

Post Your Comments:

(Date:5/20/2013)... New research suggests that a compound abundant in the ... death. , By altering a very specific step ... into normal cells that die as scheduled. , One ... process that would cause them to die on a ... study in cells, led by Ohio State University researchers, ...

(Date:5/20/2013)... - A novel vaccine study from South ... that will be unveiled at the American Association of ... takes place Monday, May 20 - Wednesday, May 22 ... , "The main goal of a vaccine is to ... that causes the disease", explained Dr. Hemachand Tummala, assistant ...

(Date:5/20/2013)... USA New Geology articles posted ... 2013 cover a wide swath of geoscience subdisciplines, ... geophysics, and paleobotany. Locations studied include Siberia; the ... Alpi Apuane, Italy; Ukraine; Mars; and the Southeastern ... 1. Rubies, jadeite, and plate tectonics;, 2. The ...

[0] The compound in the Mediterranean diet that makes cancer cells 'mortal'[0] Germ-fighting vaccine system makes great strides in delivery [0] New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More

... June 9, 2011 TGen Drug Development (TD2) and ... development of anti-cancer drugs and deliver them faster to ... highest quality medical imaging provided by Imaging Endpoints is ... Gately, President of TD2, which assists drug developers in ...

... Body cells detect signals that control their behavior through ... and disorders can result when these cilia do not work ... the journal Nature Cell Biology provides new insights ... discovery, but with implications for understanding disease," said Jonathan Scholey, ...

... able to evolve their way out of the threat posed by ... seashore animal. The work was published today (June 8) in the ... tide pool copepod Tigriopus californicus is found from Alaska ... animals showed little ability to evolve heat tolerance. "This is ...

Cached Biology News:TGen Drug Development partners with Imaging Endpoints for comprehensive clinical trial services 2 How cells' sensing hairs are made 2 Can evolution outpace climate change? 2

TGen Drug Development partners with Imaging Endpoints for comprehensive clinical trial services How cells' sensing hairs are made Can evolution outpace climate change?

(Date:5/21/2013)... 2013 SoundConnect is pleased to announce ... for customers in Canada. Lync is the next ... allow businesses and organizations to collaborate and communicate much ... Lync in the United States. With the progressive rollout ... release in Canada, SoundConnect now offers a complete Microsoft ...

(Date:5/20/2013)... , May 20, 2013 ... (USDA) Agricultural Research Service (ARS) in treatment of ... , Trials to begin in the ... drug delivery technology company Phosphagenics Limited (ASX: ... of Agriculture,s (USDA) Agricultural Research Service (ARS) to develop ...

(Date:5/20/2013)... ANGELES , May 20, 2013 Today, ... San Francisco , James McGough ... Clinical Psychiatry at the Semel Institute for Neuroscience and ... of Medicine at the University of California Los ... both Child and Adolescent Psychopharmacology and ADHD at UCLA, ...

(Date:5/20/2013)... 2013 With bed bugs' presence come problems ... bed bugs need to be eliminated, one must make sure ... person's health. And so to help bed bug sufferers get ... rid of bed bugs without using harmful pesticides. In ... it called Bed Bug Bully. , According to My Cleaning ...

Breaking Biology Technology:SoundConnect Announces Microsoft Lync Release in Canada 2 SoundConnect Announces Microsoft Lync Release in Canada 3 Phosphagenics Signs Research Agreement with the Agricultural Research Service 2 Positive Results Reported for Phase I Clinical Trial at UCLA for the Treatment of ADHD in Children Using External Trigeminal Nerve Stimulation (eTNS) 2 Positive Results Reported for Phase I Clinical Trial at UCLA for the Treatment of ADHD in Children Using External Trigeminal Nerve Stimulation (eTNS) 3 Positive Results Reported for Phase I Clinical Trial at UCLA for the Treatment of ADHD in Children Using External Trigeminal Nerve Stimulation (eTNS) 4 Positive Results Reported for Phase I Clinical Trial at UCLA for the Treatment of ADHD in Children Using External Trigeminal Nerve Stimulation (eTNS) 5 New Non Pesticide Discovery on How to Get Rid of Bed Bugs Tipped by My Cleaning Products 2

[0] SoundConnect Announces Microsoft Lync Release in Canada [0] Phosphagenics Signs Research Agreement with the Agricultural Research Service [0] Positive Results Reported for Phase I Clinical Trial at UCLA for the Treatment of ADHD in Children Using External Trigeminal Nerve Stimulation (eTNS)[0] New Non Pesticide Discovery on How to Get Rid of Bed Bugs Tipped by My Cleaning Products

... CHAPEL HILL, N.C., July 1 To effectively ... highest,rating of 3.93 out of 5 among customer ... study conducted by Best Practices, LLC,s GLOBAL,BENCHMARKING COUNCIL., ... this assessment tool, with,companies in the study,s health ...

... at M. D. Anderson Cancer Center has been charged with providing ... , ... HOUSTON (Business Wire EON) July 1, 2008 ... to document activities within the laboratory workflow at its siRNA facility, ...

... applications for positions, RESEARCH TRIANGLE PARK, N.C., ... unveiled a unique fellowship,program to help postdoctoral scientists ... careers., The NCBC Industrial Fellowship Program will ... North Carolina,s life-science,companies. It is designed to fill ...

Cached Biology Technology:Follow-up Phone Surveys: Effective Customer Service Assessment Tool for Improving Satisfaction 2 M. D. Anderson Automates Laboratory Workflow with Stone Bond Technologies : EE-LIMS™ from Stone Bond Technologies Will Document Activities within the Laboratory Workflow at the siRNA Facility, Increasing Throughput, While Reducing Risks 2 N.C. Biotechnology Center Launches Industrial Fellowship Program 2 N.C. Biotechnology Center Launches Industrial Fellowship Program 3

Follow-up Phone Surveys: Effective Customer Service Assessment Tool for Improving Satisfaction M. D. Anderson Automates Laboratory Workflow with Stone Bond Technologies : EE-LIMS™ from Stone Bond Technologies Will Document Activities within the Laboratory Workflow at the siRNA Facility, Increasing Throughput, While Reducing Risks N.C. Biotechnology Center Launches Industrial Fellowship Program

...

... sequence analysis software with the DeCypher Engine accelerator ... you can perform searches like these from your ... database in under 6 days Align ... Use HMM analysis to compare 100,000 sequences ...

... of microplate readers combines reagent dispensing with ... affordable, easy-to-use platform for the complete range ... design and adaptability of the Infinite 200 ... a monochromator (M200) or filter (F200) system ...

Determin interaction of your protein with Echelons lipids...

Biology Products:

Attofluor cell chamber from Molecular Probes (Invitrogen)DeCypher Biocomputing Solutions from TimeLogic, a Brand of Active Motif, Inc.Infinite F200 from Tecan PIP Strips from Echelon Biosciences Inc.