Navigation Links
Pooled data examines if SNPs add to breast cancer risk

Pooling data from numerous studies has helped scientists examine specific genetic variants related to breast cancer incidence, according to a study in the October 4 issue of the Journal of the National Cancer Institute.

The Breast Cancer Association Consortium brought together data from more than 20 groups conducting breast cancer research. Numerous studies by the collaboration's groups have identified a number of single nucleotide polymorphisms' single variations in a gene, known as SNPs, that may be linked to breast cancer.

The collaborating groups identified 16 SNPs that had been analyzed by at least three of their studies. They pooled data from all studies for each SNP and assessed how frequently the genetic change occurred in breast cancer patients compared to controls.

The authors found that five of the SNPs might be linked to breast cancer risk (with borderline statistical significance) and 11 were not. They suggest that pooling data from many groups can enable large sample sizes necessary to see associations when effects are moderate.

"This study illustrates the value of large consortia for clarifying risks associated with complex diseases," the authors write.

In an accompanying editorial, John P.A. Ioannidis, M.D., of the University of Ioannina School of Medicine in Greece, calls the study an "impressive collaborative effort." He discusses the difficulty of designing studies to accurately assess the significance of rare genetic changes. He writes, "If common genetic variants modulate susceptibility to common diseases such as breast cancer, we now have excellent tools to dissect them."


'"/>

Source:Journal of the National Cancer Institute


Page: 1

Related biology news :

1. U of M researcher examines newly emerging deadly disease
2. A new study examines how shared pathogens affect host populations
3. New study examines how sense of smell affects mating and aggression in mice
4. New research examines genetics of successful aging
5. UCLA paper examines how one disease may prevent another
6. U of M study examines kidney stone prevention in astronauts
7. New research examines genetics of successful aging
8. Researcher examines polymers created with poultry feathers
9. Study examines risk of soft tissue sarcomas in hereditary retinoblastoma survivors
10. Study examines genetic risk factors for Alzheimers disease
11. New study examines brains own marijuana
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... , April 28, 2016 First quarter ... (139.9), up 966% compared with the first quarter of 2015 ... totaled SEK 589.1 M (loss: 18.8) and the operating margin was ... (loss: 0.32) Cash flow from operations was SEK 249.9 ... 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. The ...
(Date:4/15/2016)... April 15, 2016  A new partnership announced ... accurate underwriting decisions in a fraction of the ... priced and high-value life insurance policies to consumers ... With Force Diagnostics, rapid testing (A1C, Cotinine ... readings (blood pressure, weight, pulse, BMI, and activity ...
(Date:3/31/2016)... 2016   LegacyXChange, ... "Company") LegacyXChange is excited to release its ... to be launched online site for trading 100% guaranteed ... will also provide potential shareholders a sense of the ... an industry that is notorious for fraud. The video ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf ... join the faculty of the University of North Carolina Kenan-Flagler Business School ... and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s international efforts, ...
(Date:6/24/2016)... , June 24, 2016  Regular discussions on a ... take place between the two entities said Poloz. ... Ottawa , he pointed to the country,s ... the federal government. ... said, "Both institutions have common economic goals, why not sit ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Researchers at the ... commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the subject ... it now. , Diagnostic biomarkers are signposts in the blood, lung fluid or ...
(Date:6/23/2016)... Mass. , June 23, 2016   ... development of novel compounds designed to target cancer ... napabucasin, has been granted Orphan Drug Designation from ... the treatment of gastric cancer, including gastroesophageal junction ... stemness inhibitor designed to inhibit cancer stemness pathways ...
Breaking Biology Technology: