Navigation Links
Pooled data examines if SNPs add to breast cancer risk

Pooling data from numerous studies has helped scientists examine specific genetic variants related to breast cancer incidence, according to a study in the October 4 issue of the Journal of the National Cancer Institute.

The Breast Cancer Association Consortium brought together data from more than 20 groups conducting breast cancer research. Numerous studies by the collaboration's groups have identified a number of single nucleotide polymorphisms' single variations in a gene, known as SNPs, that may be linked to breast cancer.

The collaborating groups identified 16 SNPs that had been analyzed by at least three of their studies. They pooled data from all studies for each SNP and assessed how frequently the genetic change occurred in breast cancer patients compared to controls.

The authors found that five of the SNPs might be linked to breast cancer risk (with borderline statistical significance) and 11 were not. They suggest that pooling data from many groups can enable large sample sizes necessary to see associations when effects are moderate.

"This study illustrates the value of large consortia for clarifying risks associated with complex diseases," the authors write.

In an accompanying editorial, John P.A. Ioannidis, M.D., of the University of Ioannina School of Medicine in Greece, calls the study an "impressive collaborative effort." He discusses the difficulty of designing studies to accurately assess the significance of rare genetic changes. He writes, "If common genetic variants modulate susceptibility to common diseases such as breast cancer, we now have excellent tools to dissect them."


'"/>

Source:Journal of the National Cancer Institute


Page: 1

Related biology news :

1. U of M researcher examines newly emerging deadly disease
2. A new study examines how shared pathogens affect host populations
3. New study examines how sense of smell affects mating and aggression in mice
4. New research examines genetics of successful aging
5. UCLA paper examines how one disease may prevent another
6. U of M study examines kidney stone prevention in astronauts
7. New research examines genetics of successful aging
8. Researcher examines polymers created with poultry feathers
9. Study examines risk of soft tissue sarcomas in hereditary retinoblastoma survivors
10. Study examines genetic risk factors for Alzheimers disease
11. New study examines brains own marijuana
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/9/2016)... -- Vigilant Solutions announces today that an agency used its ... lead in a difficult homicide case. The agency then used ... suspect vehicle. Due to the ongoing investigation, the agency name ... the agency,s request. --> --> ... found deceased at an intersection here in the City. He ...
(Date:2/5/2016)... http://www.researchandmarkets.com/research/5kvw8m/global_facial ) has ... Facial Recognition Market 2016-2020" report to ... has announced the addition of the ... to their offering. --> Research ... the addition of the "Global Facial ...
(Date:2/3/2016)... --> --> Fourth quarter 2015:   ... fourth quarter of 2014. Gross margin was 46% (32). ... Earnings per share increased to SEK 6.39 (loss: 0.49). Cash ... --> --> January to December ... 1,142% compared with 2014. Gross margin was 43% (31). ...
Breaking Biology News(10 mins):
(Date:2/10/2016)...  Matchbook, Inc., a company specializing in procurement ... announced today the appointment of Jim Shuman ... nearly 25 years of experience in supply chain, ... two decades in executive level roles as the ... and, most recently headed global logistics and procurement ...
(Date:2/10/2016)... ... February 10, 2016 , ... HOLLOWAY AMERICA, a ... Engineering (ISPE) Rocky Mountain Chapter 21st Annual Vendor Exhibition on Thursday, February 18, ... 100 tables for its annual event, which will run from 3:00 p.m. - ...
(Date:2/10/2016)... ... 2016 , ... SonaCare Medical, LLC reports the introduction of ... monitoring. The inaugural launch of this new technology occurred over the course of ... to a HIFU technical expert at SonaCare Medical headquarters. , Sonalink allows ...
(Date:2/10/2016)... ... February 10, 2016 , ... Curoverse announced today that the ... provides capabilities for managing and processing genomic and health data at petabyte scale. ... collecting and analyzing genomic data,” said Adam Berrey chief executive officer at Curoverse. ...
Breaking Biology Technology: