Navigation Links
Pooled data examines if SNPs add to breast cancer risk

Pooling data from numerous studies has helped scientists examine specific genetic variants related to breast cancer incidence, according to a study in the October 4 issue of the Journal of the National Cancer Institute.

The Breast Cancer Association Consortium brought together data from more than 20 groups conducting breast cancer research. Numerous studies by the collaboration's groups have identified a number of single nucleotide polymorphisms' single variations in a gene, known as SNPs, that may be linked to breast cancer.

The collaborating groups identified 16 SNPs that had been analyzed by at least three of their studies. They pooled data from all studies for each SNP and assessed how frequently the genetic change occurred in breast cancer patients compared to controls.

The authors found that five of the SNPs might be linked to breast cancer risk (with borderline statistical significance) and 11 were not. They suggest that pooling data from many groups can enable large sample sizes necessary to see associations when effects are moderate.

"This study illustrates the value of large consortia for clarifying risks associated with complex diseases," the authors write.

In an accompanying editorial, John P.A. Ioannidis, M.D., of the University of Ioannina School of Medicine in Greece, calls the study an "impressive collaborative effort." He discusses the difficulty of designing studies to accurately assess the significance of rare genetic changes. He writes, "If common genetic variants modulate susceptibility to common diseases such as breast cancer, we now have excellent tools to dissect them."


'"/>

Source:Journal of the National Cancer Institute


Page: 1

Related biology news :

1. U of M researcher examines newly emerging deadly disease
2. A new study examines how shared pathogens affect host populations
3. New study examines how sense of smell affects mating and aggression in mice
4. New research examines genetics of successful aging
5. UCLA paper examines how one disease may prevent another
6. U of M study examines kidney stone prevention in astronauts
7. New research examines genetics of successful aging
8. Researcher examines polymers created with poultry feathers
9. Study examines risk of soft tissue sarcomas in hereditary retinoblastoma survivors
10. Study examines genetic risk factors for Alzheimers disease
11. New study examines brains own marijuana
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/4/2017)... BLOOMINGTON, Ill. , Oct. 4, 2017  GCE Solutions, a ... powerful new data and document anonymization solution on October 4, 2017. ... the pharmaceutical field to comply with policy 0070 of the European ... documents and data. ... Innovation by GCE Solutions ...
(Date:8/15/2017)... 15 2017   ivWatch LLC , a medical device company ... today announced receipt of its ISO 13485 Certification, the global standard ... Organization for Standardization (ISO®). ... Model 400 Continuous Monitoring device for the early detection of IV ... "This is an important milestone for ...
(Date:6/30/2017)... 30, 2017 Today, American Trucking Associations ... of face and eye tracking software, became the ... program. "Artificial intelligence and advanced ... monitor a driver,s attentiveness levels while on the ... to detect fatigue and prevent potential accidents, which ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for its 4th ... in San Francisco, CA. The Summit brings together current and former FDA office bearers, ... and government officials from around the world to address key issues in device compliance, ...
(Date:10/11/2017)... , ... October 11, 2017 , ... Disappearing forests and ... lives of over 5.5 million people each year. Especially those living in larger cities ... Treepex - based in one of the most pollution-affected countries globally - decided to ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that ... Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital Los ...
(Date:10/10/2017)... 10, 2017 SomaGenics announced the receipt of ... develop RealSeq®-SC (Single Cell), expected to be the first ... (including microRNAs) from single cells using NGS methods. The ... to accelerate development of approaches to analyze the heterogeneity ... "New techniques for measuring levels of mRNAs in individual ...
Breaking Biology Technology: