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Polymer gel can block toxic leakage problem in gene therapy

ject the genes into the bloodstream. But that won't work because the virus particles are too large to get through to the tumor.

"Therefore, the only choice is to inject the viral particles directly into the tumor. But when you do that, we have demonstrated that dissemination elsewhere is inevitable. The result is that more will reach normal tissue than be left in the tumor. And that may cause all kinds of toxicity problems.

"In our first new paper we demonstrated the mechanism of this dissemination. And in the second paper we developed a solution to block it."


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Source:Duke University


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