Navigation Links
Polymer gel can block toxic leakage problem in gene therapy

2005 issue of the journal Cancer Research the researchers proposed a solution to the viral escape problem in the form of a polymer compound already employed for wound healing and for drug and gene delivery.

After being mixed with a gene-bearing virus, this compound -- called poloxamer 407 -- undergoes a temporary phase change as its stiffens from a liquid to a gel state when warmed to body temperature, that study reported.

This 1,000-fold viscosity change only lasts 10 to 90 minutes, long enough to clog the escape route for large numbers of viruses so those will link up with and infect tumor cells instead, Yuan said.

The Duke team found the polymer-virus mixture "could reduce virus dissemination by two orders of magnitude (100 times) and significantly increase transgene expression in solid tumors," their study reported.

In comparative tests on breast tumors implanted in live mice, the authors noted that two mice in the group injected with adenoviruses without poloxamer died within a half hour after administration. "But mice in the poloxamer group did not show any problem," they wrote.

Additional studies using the glowing protein to trace viral dissemination showed that "the poloxamer solution could significantly reduce the transgene expression in the liver and increase the transgene expression in the tumor," they reported.

Yuan said he has applied for a provisional patent covering this new use of poloxamer 407, which his group purchased from the BASF Corp.

In 2003, Yuan, Wang, Krol, Li and other Duke researchers previously reported that another chemical extracted from common brown algae can also block toxic leakages from tumor injections when mixed with the adenoviruses. However, the high viscosity of that jello-like mixture made it hard to inject.

"The bottom line is that when people try to do gene therapy on cancer they must inject the genes into the tumor," Yuan said. "One way would be to try and in
'"/>

Source:Duke University


Page: 1 2 3 4

Related biology news :

1. Polymers with copper show promise for implanted sensors
2. Polymer aids in blood clotting, pointing way to new treatment
3. Polymers show promise for lab-on-a-chip technology
4. Tamoxifen-like drug suggests new ways to selectively block estrogen
5. New type of rejection blocker protects kidneys after transplant
6. Frog peptides block HIV in lab study
7. Survival of heart patients on beta-blockers varies greatly with genetic variation
8. Newfound roadblock to interferon effectiveness against malignant melanoma
9. UCSD study clarifies insulins role in blocking release of energy in patients with type II diabetes
10. Scientists use gene transfer technology and common virus to block neuropathic pain in animals
11. Scientists use gene transfer technology and common virus to block neuropathic pain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Polymer gel can block toxic leakage problem gene therapy

(Date:8/5/2015)... Transparency Market Research has released ... Global Industry Analysis, Size, Share, Growth, Trends and Forecast ... is forecast to reach US$ 2,671.8 Mn by 2022. ... systems by civil and government agencies. This is majorly ... activities across the globe that would elevate the demand ...
(Date:7/31/2015)... SHENZHEN , Kina, 31. juli 2015 ... ) bliver afholdt af BGI fra den 22. - 25. ... Konferencen fejrer sin 10-års fødselsdag i år. ... verdens mest indflydelsesrige årlige møder på ,omik,-feltet, og er ... forsamlinger. ICG-10 fokuserer på nylige gennembrud ...
(Date:7/31/2015)... Die 10. internationale Konferenz zu Genomik (ICG-10, ... vom 22. bis 25. Oktober 2015 in ... Die Konferenz feiert in diesem Jahr ihr ... ICG weltweit zu einem der einflussreichsten jährlichen Treffen ... dynamischsten, enthusiastischsten und angenehmsten wissenschaftlichen Zusammentreffen. ...
Breaking Biology News(10 mins):Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 4Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 5Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 6Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3
... New discoveries on how underwater ridges impact the ocean,s ... ridge can trap the flow of cold, dense water at ... flow freely and speed up the ocean circulation pattern, which ... Warm water on the ocean,s surface makes the formation of ...
... Mars or any planet, there is much more than the ... cycles as a reference point, elements like nitrogen, iron and ... in studies published in February,s open-access Special Issue of Frontiers ... together to support an extraordinary diversity of life. ...
... that make engineered nanoparticles attractive for numerous applicationssmall as ... concern about their long-term impacts on environmental health and ... to clump together in solution, is of great interest ... to whether or not they are toxic to human ...
Cached Biology News:Earth's life support systems discussed in an open-access special issue 2NIST technique controls sizes of nanoparticle clusters for EHS studies 2
(Date:8/27/2015)... - Portage Biotech Inc. ("Portage") (OTC Market: PTGEF, ... Company Limited (Biohaven), announced today that dosing has ... a glutamate modulating agent. Biohaven filed an investigational ... clearance from the U.S. Food and Drug Administration ... 54% equity interest in Biohaven, a private company. ...
(Date:8/27/2015)... DIEGO , Aug. 27, 2015 HUYA ... annual meeting of the Japan Society of HTLV-1, held ... Institute Auditorium. The purpose of the Society is to ... as the development of medical technology and research related ... and welfare. "HUYA is proud to support ...
(Date:8/27/2015)... PARK, N.C. , Aug. 27, 2015 /PRNewswire/ ... the decision by FedEx, UPS and The US ... certain biological specimens classified as ,select agents, by ... long history of handling these sensitive shipments. ... of global transportation regulations, trained and certified personnel ...
(Date:8/26/2015)... N.J. , Aug. 26, 2015  Roka Bioscience, ... focused on providing advanced testing solutions for the detection ... CEO will present at the Sidoti & Company Emerging ... conference will be held at the New York Marriott ... presentation will be available through the investor relations section ...
Breaking Biology Technology:Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4Marken Ensures Safe Transportation Of Select Agents And Toxins 2
... ... sensitivity , ... Surrey, British Columbia (PRWEB) August 24, 2009 -- QImaging, a leading developer ... has announced the release of the EXi Aqua Bio-imaging Microscopy Camera. This product ...
... their popularity in the science fiction genre, there is much ... space once thought to be absent of light. In a ... Review Letters , the flagship journal of the American Physical ... reproduction black hole in the laboratory on a much-tinier scale ...
... , , , ... SIAL ) announced today that scientists at its new Sigma Advanced Genetic ... Finger Nuclease (ZFN) gene editing technology ( www.c o ... genetically-engineered rodent research models. Such models are commonly used to study disease ...
Cached Biology Technology:QImaging Introduces EXi Aqua™ Microscopy Camera for Bio-Imaging 2QImaging Introduces EXi Aqua™ Microscopy Camera for Bio-Imaging 3Dartmouth researchers propose new way to reproduce a black hole 2New Sigma Advanced Genetic Engineering Labs Offers Research Community Unique Rodent Models Developed Using Exclusive Gene-Editing Technology 2New Sigma Advanced Genetic Engineering Labs Offers Research Community Unique Rodent Models Developed Using Exclusive Gene-Editing Technology 3
Kit containing MACS equipment and reagents for immunopurification of proteins....
... poor quality running into billions of ... under increasing pressure to reduce expensive ... microscopic distribution of ingredients is known ... as dissolution, stability, bio-availability and hardness. ...
... Speed Shaker ,Product Information ... is a high quality, general purpose shaker with ... the other models in the line, the Orbit ... control panel. Electronic controls are utilized for setting ...
This modular benchtop laminar flow hood forces air through a 99.99% efficient HEPA filter to create a clean processing area. Options include a work bench, ionizaing bar, and air velocity gauge....
Biology Products: