Navigation Links
Polymer gel can block toxic leakage problem in gene therapy

ene-bearing viruses to escape their intended target and pose risks elsewhere, the researchers found in a study the researchers reported in the April 2005 issue of the British Journal of Cancer.

In that study, the researchers injected adenoviruses that produce glowing proteins in order to trace where the viral particles went during 24 hours after being injected into breast tumors implanted in experimental mice.

That investigation showed that 10 times more of the viral particles were transported to other organs than were retained within the tumors. And most of the errant viruses ended up in the liver, where the gene therapy protein products could cause cell death. Moreover, most viruses escaped from their intended tumor targets during the first 10 minutes.

Prompted by reports of animal deaths during past gene therapy trials with adenoviruses, this study provided the first direct research evidence that therapeutic gene-bearing viruses were being disseminated away from the tumor site via the blood stream, Yuan said. "In the past people wouldn't admit that," he said. "Nobody in the gene therapy field would believe this was happening."

The study also pinpointed the routes for the viral escapes. Those particles were escaping from the tumor area into the bloodstream through rifts in tiny tumor blood vessels created by damage from the injection needle.

Yuan said such viral escapes are inevitable since the needle's diameter is 30 times larger than the width of the microvessels that supply the tumor with blood. The needle is also wider than the spaces between each of those vessels, he added.

The first author of the British Journal of Cancer study was Yuan's graduate student Yong Wang. Other authors included Yuan, Yuan's research associate Ava Krol, associate research professor of radiation oncology Chuan-Yuan Li, and radiation oncology research associates Shanling Liu and Takashi Kon.

In a followup study in the September
'"/>

Source:Duke University


Page: 1 2 3 4

Related biology news :

1. Polymers with copper show promise for implanted sensors
2. Polymer aids in blood clotting, pointing way to new treatment
3. Polymers show promise for lab-on-a-chip technology
4. Tamoxifen-like drug suggests new ways to selectively block estrogen
5. New type of rejection blocker protects kidneys after transplant
6. Frog peptides block HIV in lab study
7. Survival of heart patients on beta-blockers varies greatly with genetic variation
8. Newfound roadblock to interferon effectiveness against malignant melanoma
9. UCSD study clarifies insulins role in blocking release of energy in patients with type II diabetes
10. Scientists use gene transfer technology and common virus to block neuropathic pain in animals
11. Scientists use gene transfer technology and common virus to block neuropathic pain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Polymer gel can block toxic leakage problem gene therapy

(Date:6/18/2013)... University of Calgary,s Faculty of Medicine have discovered a ... harmful bacteria. Platelets, a component of blood typically associated ... bacteria, and upon detection, seal it off from the ... in Nature Immunology this week, provide the ... "The science community has known that platelets do participate ...
(Date:6/18/2013)... Research Council, Laboratory of Molecular Biology, has been ... Young Investigator Award. Torrent is being recognized for ... algorithm to predict antimicrobial regions in proteins. Luis ... now applying this algorithm to interrogate full genomes ... with very appealing results." , Torrent obtained ...
(Date:6/18/2013)... It is estimated that between 5% and 10% of ... is to say that these tumours are attributable to ... BRCA1 or BRCA2. In patients with these mutations, PARP ... encouraging results that make them a new option for ... the latest studies indicate that a fraction of these ...
Breaking Biology News(10 mins):Immunity mechanism discovered 2The American Society for Microbiology honors Marc Torrent 2An article in 'Cell' reveals a new resistance mechanism to chemotherapy in breast and ovarian cancer 2
... blocks the brain’s ability to strengthen connections at inhibitory synapses, ... The findings, uncovered in the laboratory of Brown scientist Julie ... brain. The research also supports a provocative new theory of ... "We’ve added a new piece to the puzzle of how ...
... three sexually active older adults infected with HIV has unprotected ... survey of 260 HIV-positive older adults found that of those ... a relationship. , AIDs cases among the over-50 crowd reached ... and Prevention, they will account for half of all HIV/AIDS ...
... Beucken and John Jansen have given body implants a DNA ... of the surrounding tissue and less immune responses. The older ... placing such parts yielded advantages, but also disadvantages such as ... easier and more reliable to use implants and has already ...
Cached Biology News:Morphine makes lasting -- and surprising -- change in the brain 21/3 of sexually active older adults with HIV/AIDs has unprotected sex 2DNA layer reduces risk of reserve parts being rejected 2
(Date:6/19/2013)... Clinverse, Inc. , a ... trials, today announced it will be exhibiting and ... in Boston, June 24-26, 2013. Clinverse’s eClinical ... fully configurable, cloud-based clinical financial lifecycle system. , ... Clinverse’s eClinical Commerce Network, automates site contract set-up ...
(Date:6/19/2013)... June 19, 2013 Bayer CropScience will ... Bayer Bee Care Community Leadership Award. The award will ... Congressional Reception in Washington, D.C., an event where supporters ... the world’s food supply. , The Bayer Bee ... the power of the honey bee colony to benefit ...
(Date:6/19/2013)... Canada (PRWEB) June 19, 2013 ... trial business can potentially be worth up to ... this opportunity, the Indian government is taking serious ... trials the process. , This presentation will examine:, ... trial regulations ,     Immediate and long term ...
(Date:6/18/2013)... June 18, 2013 Tabletop SEMs are ... SEMs but have limited performance and capability such as ... size SEMs would normally provide better imaging performance and ... operate and have a higher cost of maintenance. ... gap between these two types of SEM product, offering ...
Breaking Biology Technology:Clinverse, Inc. Exhibiting and Showcasing Its Technology at DIA 2013 2Community Mentor Wins Inaugural Bayer CropScience Bee Care Leadership Award 2Community Mentor Wins Inaugural Bayer CropScience Bee Care Leadership Award 3Community Mentor Wins Inaugural Bayer CropScience Bee Care Leadership Award 4Nanounity Introduces the Pemtron Range of Compact Scanning Electron Microscopes 2Nanounity Introduces the Pemtron Range of Compact Scanning Electron Microscopes 3
... 19, 2011 , , • ... MS drug with neuroprotective effects that does not cause,immunosuppression. ... the first,to be administered orally, whereas the few treatments ... significant side effects. • NeuroAdvan, the ...
... Mosquitoes die soon after a blood meal if certain ... at the University of Arizona has discovered. The ... the worldwide effort to curb mosquito-borne diseases like dengue ... blocked a cellular process known as vesicle transport, on ...
... dots made from cadmium and selenium degrade in soil, ... a University at Buffalo study has found. The ... Science and Technology , demonstrates the importance of learning ... -- interact with the environment after disposal, said Diana ...
Cached Biology Technology:Start of in-Patient Clinical Trials With NT-KO-003, the First Neuroprotective Drug for Multiple Sclerosis Without Immunosuppressive Effects 2Start of in-Patient Clinical Trials With NT-KO-003, the First Neuroprotective Drug for Multiple Sclerosis Without Immunosuppressive Effects 3Start of in-Patient Clinical Trials With NT-KO-003, the First Neuroprotective Drug for Multiple Sclerosis Without Immunosuppressive Effects 4Start of in-Patient Clinical Trials With NT-KO-003, the First Neuroprotective Drug for Multiple Sclerosis Without Immunosuppressive Effects 5Making blood-sucking deadly for mosquitoes 2Making blood-sucking deadly for mosquitoes 3Making blood-sucking deadly for mosquitoes 4Cadmium selenide quantum dots degrade in soil, releasing their toxic guts, study finds 2Cadmium selenide quantum dots degrade in soil, releasing their toxic guts, study finds 3
... sulfate-free, powder containing carbohydrate and citrate ... Definition: One unit will convert 1.0 ... to D -glucose 6-phosphate per ... C. Chem comp: Protein ...
... Vector is specifically designed to target and ... Saccharomyces cerevisiae. Displayed proteins can be analyzed ... or putative ligands. pYD1 uses the a-agglutinin ... domains Aga1 and Aga2 to display recombinant ...
... Polyclonal Antibody against Aph-1a (Aph-1aL,S Loop ... gamma secretase is a multiprotein complex ... Pen-2; all four proteins are necessary ... secretase complex catalyzes cleavage of a ...
TGase3 (S-20)...
Biology Products: