Navigation Links
Polymer gel can block toxic leakage problem in gene therapy

ene-bearing viruses to escape their intended target and pose risks elsewhere, the researchers found in a study the researchers reported in the April 2005 issue of the British Journal of Cancer.

In that study, the researchers injected adenoviruses that produce glowing proteins in order to trace where the viral particles went during 24 hours after being injected into breast tumors implanted in experimental mice.

That investigation showed that 10 times more of the viral particles were transported to other organs than were retained within the tumors. And most of the errant viruses ended up in the liver, where the gene therapy protein products could cause cell death. Moreover, most viruses escaped from their intended tumor targets during the first 10 minutes.

Prompted by reports of animal deaths during past gene therapy trials with adenoviruses, this study provided the first direct research evidence that therapeutic gene-bearing viruses were being disseminated away from the tumor site via the blood stream, Yuan said. "In the past people wouldn't admit that," he said. "Nobody in the gene therapy field would believe this was happening."

The study also pinpointed the routes for the viral escapes. Those particles were escaping from the tumor area into the bloodstream through rifts in tiny tumor blood vessels created by damage from the injection needle.

Yuan said such viral escapes are inevitable since the needle's diameter is 30 times larger than the width of the microvessels that supply the tumor with blood. The needle is also wider than the spaces between each of those vessels, he added.

The first author of the British Journal of Cancer study was Yuan's graduate student Yong Wang. Other authors included Yuan, Yuan's research associate Ava Krol, associate research professor of radiation oncology Chuan-Yuan Li, and radiation oncology research associates Shanling Liu and Takashi Kon.

In a followup study in the September
'"/>

Source:Duke University


Page: 1 2 3 4

Related biology news :

1. Polymers with copper show promise for implanted sensors
2. Polymer aids in blood clotting, pointing way to new treatment
3. Polymers show promise for lab-on-a-chip technology
4. Tamoxifen-like drug suggests new ways to selectively block estrogen
5. New type of rejection blocker protects kidneys after transplant
6. Frog peptides block HIV in lab study
7. Survival of heart patients on beta-blockers varies greatly with genetic variation
8. Newfound roadblock to interferon effectiveness against malignant melanoma
9. UCSD study clarifies insulins role in blocking release of energy in patients with type II diabetes
10. Scientists use gene transfer technology and common virus to block neuropathic pain in animals
11. Scientists use gene transfer technology and common virus to block neuropathic pain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Polymer gel can block toxic leakage problem gene therapy

(Date:9/2/2014)... University of Warwick in the UK and the Ruhr-University ... Early Human Development , has found that both ... and the use of mechanical ventilation are key indicators ... abilities are crucial for lifelong academic attainment. Impairments in ... studies of children who are born very preterm (before ...
(Date:9/2/2014)... birds, also known as perching birds, that migrate by ... do in autumn to reach their destinations. This seasonal ... that only make short migratory flights, says researcher Cecilia ... Behavioral Ecology and Sociobiology . , Nilsson, ... a tracking radar to measure over three years the ...
(Date:9/2/2014)... spiky legs and their propensity for eating anything, including ... And now research from North Carolina State University finds ... across the eastern United States. , "The good news ... kind of threat to humans," says Dr. Mary Jane ... author of a paper about the research. , The ...
Breaking Biology News(10 mins):Mechanical ventilation a key indicator for pre-term children's math problems 2Migrating birds sprint in spring, but take things easy in autumn 2Researchers find Asian camel crickets now common in US homes 2
... Exotic bacteria that do not rely on oxygen may have ... early atmosphere, according to a theory that UChicago researcher Albert ... volcanic crater in Siberia. He has found that bacteria ... a surprising twist that scientists must take into account as ...
... WASHINGTON, April 26, 2011 The American Chemical Society ... " Global Challenges/Chemistry Solutions " podcast series showcasing ... friendly production of a key ingredient used to make ... and accompanying website focus on a new way to ...
... Group announced today that four individuals, representing Chile, Mexico ... in Marine Conservation. The 2011 Pew Marine ... dolphin populations, measure the economic and ecological tradeoffs of ... scientific foundation for the establishment of marine protected areas ...
Cached Biology News:Cold case: Siberian hot springs reveal ancient ecology 2Cold case: Siberian hot springs reveal ancient ecology 3Pew announces 2011 recipients of distinguished marine conservation fellowship 2
(Date:9/2/2014)... Quincy, MA (PRWEB) September 02, 2014 ... announced today the signage of a distribution agreement ... Azelis is now distributing Myriant’s bio-succinic acid in ... Kingdom and Ireland, targeting customers in the industrial ... chemical distribution powerhouse, Azelis offers a far-reaching chemical ...
(Date:9/2/2014)... Sept. 2, 2014  Xencor, Inc. (NASDAQ: ... engineered monoclonal antibodies for the treatment of autoimmune ... announced the appointment of Debra Zack , ... appointment of Lloyd Rowland , senior vice ... "Debra,s expertise in biologics clinical development ...
(Date:9/2/2014)... /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today ... of three large odour control systems for waste water treatment ... orders are consistent with the market resurgence in ... and CEO. "After a difficult period of restraint in our ... see sales growth. Our lower cost structure, technology improvements and ...
(Date:9/2/2014)... Massachusetts , September 2, 2014 ... to BioData,s research and lab management services  ... management service, is pleased to announce the appointment of ... Culot most recently served as VP Marketing and Business ... life science research and clinical applications. Previously, ...
Breaking Biology Technology:Myriant and Azelis Sign European Distribution Agreement for Bio-Succinic Acid 2Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 2Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 3Louis Culot Appointed as BioData's CEO 2
... Monogram,Biosciences, Inc. (Nasdaq: MGRM ) announced today ... Financial Officer, is,scheduled to present a corporate overview ... 13, 2007 at 11:00 a.m. (Eastern Time) at,the ... access the live audio broadcast or the subsequent ...
... CALL DATE: Oct. 31, 2007 TIME: 8:30 a.m. Eastern Time HOST: Dr. ... ... KNDL ),will conduct a telephone conference call and simultaneous webcast Oct. 31,at ... 2007. A question and answer session will follow. (Logo: http://www.newscom.com/cgi-bin/prnh/20030429/KNDLLOGO ...
... leading,management consulting firm specializing in the pharmaceutical and biotech,industries, ... of the best,places to work in the Research Triangle ... ranking third among midsize companies. The award,was presented to ... to Work luncheon and awards ceremony on September 27, ...
Cached Biology Technology:Monogram Biosciences to Present at the JMP Securities Healthcare Conference 2Kendle Invites You to Attend Its Third Quarter 2007 Earnings Conference Call and Webcast 2Campbell Alliance Named 'Best Place to Work' by Triangle Business Journal 2
Recombinant Feline IL-2, CF...
Recombinant Equine IL-4, CF...
Recombinant Rat Leptin, CF...
VACUGENE PUMP 110V, 1 EA. Category: Nucleid Acid Detection Systems....
Biology Products: