Navigation Links
Polymer aids in blood clotting, pointing way to new treatment

A serendipitous comparison prompted by an old scientific image and involving an ancient but understudied molecule may lead to a new treatment strategy for injuries or illnesses in which blood clotting is paramount to survival.

In a paper to be published in the Proceedings of the National Academy of Sciences, researchers from the University of Illinois at Urbana-Champaign and the University of Georgia report that a linear polymer known as polyphosphate speeds blood clotting and helps clots last longer. The paper appears online this week (Jan. 9-14) on the PNAS Web site.

Polyphosphate was shown to have three important roles, said James H. Morrissey, a biochemist in the U. of I. College of Medicine at Urbana-Champaign. The inorganic compound accelerates two parts of the coagulation cascade -- the contact-activation pathway and factor V, a protein that forms thrombin -- leading to fibrin and clots. Finally, he said, polyphosphate delays the breakdown of clots, which causes renewed bleeding.

"The net effect is accelerating the rate at which blood clots form and then prolonging how long they last," Morrissey said.

The successful research already has landed the U. of I. a three-year, $300,000 grant from the Roy J. Carver Charitable Trust to establish the Center for Hemostasis Research. The grant, which began Nov. 1, involves three U. of I. labs with Morrissey in the lead.

The PNAS report comes about a year after former Illinois scientist Roberto Docampo, now a professor of cellular biology at Georgia's Center for Tropical and Emerging Global Diseases, documented in the Journal of Biological Chemistry (Oct. 22, 2004) that dense granules in human platelets contain polyphosphate.

In the early 1990s, Docampo determined that a tiny granule, a subcellular pouch, in yeast, fungi and bacteria -- long thought to be for storage -- was a fully operational organelle. It contained pyrophosphatase, a pump-like enzyme that allows proton tran
'"/>

Source:University of Illinois at Urbana-Champaign


Page: 1 2 3 4

Related biology news :

1. Polymers with copper show promise for implanted sensors
2. Polymer gel can block toxic leakage problem in gene therapy
3. Polymers show promise for lab-on-a-chip technology
4. White blood cell waste disposal system plays critical regulatory role
5. Epstein-Barr virus protein crucial to its role in blood cancers
6. New insight into regulation of blood stem cells
7. Nano-bumps could help repair clogged blood vessels
8. First technology to remove prions that cause vCJD from blood launched
9. Breakthrough isolating embryo-quality stem cells from blood
10. Thai spice helps cut blood sugar swings
11. Study shows humans have ability to track odors, much like bloodhounds
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Polymer aids blood clotting pointing way new treatment

(Date:6/18/2013)... Faculty of Medicine have discovered a mechanism that is ... a component of blood typically associated with clotting, were ... detection, seal it off from the rest of the ... Immunology this week, provide the science community with ... has known that platelets do participate in immunity, but ...
(Date:6/18/2013)... United Kingdom, the Energy Department,s National Renewable Energy ... recently published a paper describing a novel cellulose-degrading ... quadripunctata , commonly known as the gribble. ... a relatively unique ability to produce their own ... down the biomass they eat. New biomass-degrading enzymes ...
(Date:6/18/2013)... A UT Arlington environmental engineer has been awarded ... District to ensure water quality and flow in ... Project. , Andrew Kruzic, UT Arlington associate professor ... and locations to add monochloramine to the water ... the new pump stations and pipelines. Adding monochloramine ...
Breaking Biology News(10 mins):Immunity mechanism discovered 2Novel enzyme from tiny gribble could prove a boon for biofuels research 2UT Arlington research to benefit quality, flow in 150-mile Integrated Pipeline 2
... Disease Control and Prevention estimates that almost 18% of ... our growing obesity "epidemic" is driven by both inadequate ... extraordinarily difficult. One area that has caught the attention ... video game playing parallel obesity rates on a population ...
... the smoking ban in restaurants, bars and nightclubs, customers ... odors and the smell of old beer, that used ... looking at how the introduction of pleasant ambient scents ... According to Dr. Hendrik Schifferstein from Delft University of ...
... May 17, 2010 Country roadways can be hazardous for ... with moose, elk and caribou in North America and Europe ... the salt pools that collect following pavement deicing. ... with males weighing up to 720 kilograms, their salt cravings ...
Cached Biology News:Rigorous study confirms video game playing increases food intake in teens 2Clubbers can smell a good nightspot 2Of moose and men 2
(Date:6/18/2013)... HONG KONG, June 18, 2013 China Cord ... the "Company"), China,s leading provider of cord blood collection, ... storage services, today announced its preliminary unaudited financial results ... year 2013 ended March 31, 2013. ... for the fourth quarter of fiscal 2013 increased by ...
(Date:6/18/2013)... York, NY (PRWEB) June 18, 2013 ... innovation and sustainability, the Consulate General of Switzerland in ... solar boat, Switzerland’s MS Tûranor PlanetSolar , to ... part of its DeepWater Expedition 2013 tour with scientists ... led by Capitain Gérard d’Aboville, runs exclusively on energy ...
(Date:6/18/2013)... 2013 (PRWEB) June 18, 2013 ... system in North America, has introduced AccountLinx Plus, ... and payroll records between ExakTime’s software and industry-leading ... ExakTime software setup and keeps employee databases up-to-date ... from a business’ current payroll software, directly into ...
(Date:6/18/2013)... MD, USA (PRWEB) June 18, 2013 ... announced the opening of two new offices in Asia—one ... in Singapore will serve as RAPS’ Pan-Asia office ... office will be more focused on audiences within China. ... RAPS announced its partnership with five Singapore government agencies ...
Breaking Biology Technology:China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 2China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 3China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 4China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 5China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 6China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 7China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 8China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 9China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 10China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 11China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 12China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 13Switzerland’s MS Tûranor PlanetSolar, the World’s Largest Solar Boat, Arrives in New York City 2Switzerland’s MS Tûranor PlanetSolar, the World’s Largest Solar Boat, Arrives in New York City 3Switzerland’s MS Tûranor PlanetSolar, the World’s Largest Solar Boat, Arrives in New York City 4ExakTime Introduces AccountLinx Plus 2RAPS Opens Offices in Singapore and China 2RAPS Opens Offices in Singapore and China 3
... KOSN ) will announce its first quarter 2008 ... The announcement of Kosan,s first quarter 2008 financial ... webcast on May 1, 2008 at 1:30,p.m. Pacific / ... by dialing 888.680.0878 (US) or 617.213.4855 (international), access,code 63268386. ...
... SAN FRANCISCO, Calif., April 24 ,Exelixis, Inc. (Nasdaq: ... and chief executive officer of Exelixis, will present at ... ET/12:40,p.m. PT on Wednesday, April 30, 2008. Dr. Scangos ... strategy., The presentation will be webcast and may ...
... HOLX ), a diversified medical technologies company ... dedicated to,serving the healthcare needs of women, today ... operating results on Thursday, May 1, 2008 at,8:00 ... will host,a conference call on Thursday, May 1, ...
Cached Biology Technology:Kosan Announces May 1, 2008 Conference Call and Webcast of First Quarter 2008 Financial Results 2Hologic, Inc. to Release Second Quarter Fiscal 2008 Operating Results Thursday, May 1st Before Market Opens 2
Mouse Wnt-11 Affinity Purified Polyclonal Ab...
PEG 8000, Molecular Biology Grade...
Human VASA Biotinylated Affinity Purified PAb...
Recombinant Mouse Matrilin-4, CF Protein Family: Extracellular Matrix Molecules, Chondrogenesis Markers...
Biology Products: