Navigation Links
Plants, animals share molecular growth mechanisms

A newly discovered plant protein complex that apparently switches on plants' growth machinery, has opened a scientific toolbox to learn about both plant and animal development, according Purdue University scientists.

The protein complex triggers communication between molecules along a pathway that leads to the creation of long protein strings, called actin filaments, that are necessary for cellular growth, said Dan Szymanski, agronomy associate professor and lead author of the study. Knowledge of the biochemical reactions involved in this process eventually may allow researchers to design plants better able to protect themselves from insects and disease.

"These genes and their proteins are required for normal development and for normal cell-to-cell adhesion," Szymanski said. "They affect the growth of the whole plant and also the shape and size of types of cells in the plant."

Results of the study are published in the February issue of the journal The Plant Cell.

"Perhaps by learning about this pathway for actin filament formation, we can engineer plant cells to grow in different ways or alter how cells respond to external stimuli so they can defend themselves against insect or fungal attacks," Szymanski said.

A protein complex known as Actin Related Protein 2/3 (ARP2/3) is a cellular machine that controls formation of actin filaments, which are important for cell growth and movement. Actin filaments organize the inside of the cell and allow it to grow, and they determine where certain structures in a cell are positioned and how plants respond to gravity and light.

Szymanski's team used a deformed version of a common research plant, Arabidopsis thaliana, and specifically looked at small, hairlike structures that exist on most cells. They found that the shape and size of these hairs, or trichomes, readily show when genes affecting actin filaments are askew and causing altered growth.

The researchers previously ha d learned that a large protein complex, known as WAVE, activated ARP2/3, but they didn't know specifically which WAVE protein was the actual switch. Their latest research showed that a WAVE protein they've dubbed DISTORTED3 (DIS3) turns on APR 2/3, which in turn triggers formation of new, growing actin filaments.

Because some genes have survived through time as multicellular life evolved, they have been conserved in both plants and animals, Szymanski said. So, some of the plant proteins that comprise the ARP2/3 and the WAVE complexes are interchangeable with proteins in animals. Others proteins are not interchangeable, and Szymanski's research team is delving into how this affects the growth process.

"DIS3 has two ends that are common in both plant and animal proteins," he said. "But DIS3 has a very large segment in the middle that is specific to plants. We'd like to know if this section is important and whether it regulates DIS3 or the whole WAVE complex."

For growth and development biochemical processes to proceed normally, activators such as ARP 2/3 are needed to trigger actin filaments' formation and growth, Szymanski said. However, scientists don't know the specific function of certain actin filaments. The molecular tools Szymanski's research team developed will help scientists learn more about these functions in both plants and animals.

The other researchers on this study were Dipanwita Basu and Salah El-Din El-Essal, research assistants; postdoctoral students Jie Le, Chunhua Zhang and Gregore Koliantz; Eileen Malley, laboratory manager, all of the Department of Agronomy; and Shanjin Huang, postdoctoral student, and Christopher Staiger, professor, both of the Department of Biological Sciences. Staiger and Szymanski also are members of the Purdue Motility Group.

Related Websites :

Purdue Department of Agronomy

Purdue Motility Group

The Plant Cell

DOE Office of Science


'"/>

Source:Purdue University


Related biology news :

1. Plants, too, have ways to manage freeloaders
2. Elephants imitate truck noises, other animals
3. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
4. Gene therapy for Parkinsons disease moves forward in animals
5. Use of PET can reduce, may eliminate more strenuous drug development trials with animals
6. Undesirable expatriates: Preventing the spread of invasive animals
7. Two new retroviruses—transmitted from animals—identified
8. Stem cell therapy successfully treats heart attack in animals
9. More animals join the learning circle
10. Proposal would allow wild animals to roam North America
11. Research suggests fitness of Florida panthers improved by limited breeding with Texas animals
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/16/2016)... June 16, 2016 The ... expected to reach USD 1.83 billion by 2024, ... Research, Inc. Technological proliferation and increasing demand in ... expected to drive the market growth. ... The development of advanced multimodal techniques for ...
(Date:6/9/2016)... -- Perkotek an innovation leader in attendance control systems is proud to announce the introduction ... to make sure the right employees are actually signing in, and to even control ... ... ... ...
(Date:6/7/2016)... June 7, 2016  Syngrafii Inc. and San ... relationship that includes integrating Syngrafii,s patented LongPen™ eSignature ... This collaboration will result in greater convenience for ... union, while maintaining existing document workflow and compliance ... ...
Breaking Biology News(10 mins):
(Date:6/23/2016)...  Blueprint Bio, a company dedicated to identifying, protecting ... has closed its Series A funding round, according to ... "We have received a commitment from Forentis Fund that ... meet our current goals," stated Matthew Nunez . ... complete validation on the current projects in our pipeline, ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the ... Convention Center and will showcase its product’s latest features from June 26 to ... a scientific poster on Disrupting Clinical Trials in The Cloud during the conference. ...
(Date:6/23/2016)... FRANCISCO , June 22, 2016  Amgen (NASDAQ: ... sponsorship of the QB3@953 life sciences incubator ... human health. The shared laboratory space at QB3@953 was ... overcome a key obstacle for many early stage organizations ... part of the sponsorship, Amgen launched two "Amgen Golden ...
(Date:6/22/2016)... , June 22, 2016 Research and ... Global Markets" report to their offering. ... billion in 2014 from $29.3 billion in 2013. The market is ... of 13.8% from 2015 to 2020, increasing from $50.6 billion in ... projected product forecasts during the forecast period (2015 to 2020) are ...
Breaking Biology Technology: