Navigation Links
Plant gene related to cancer treatment may foster new oncology drugs

they found that other PGP proteins move auxin into cells.

"Auxin molecules essentially are pulled through the cell membrane by PGP transport proteins," Murphy said. "It's an energetic process that happens like pulling a rope through something sticky."

Both the multi-drug resistant PGPs in people and plants are part of a large family of proteins, called ATP-binding cassette (ABC) proteins, that act as delivery trucks to detoxify cells, send messages from cell to cell to influence biochemical reactions, and to regulate those reactions. The ABC proteins are so named because they must bind with ATP, the main cell energy source, in order to fulfill their mission.

The best known member of another class of transport proteins, PIN1, also may be a transporter, but appears to function primarily as an aide rather than the delivery truck for auxin transport, Murphy said. This finding revealed that PINs and PGPs may function together in long-distance auxin transport, according to the Plant Journal article. Named for the pin-shaped appearance of the mutant originally used to identify the gene that directs the activities of PIN1, these proteins are members of the major protein family, called facilators, that aid processes such as hormone transport.

Recent evidence suggests that teamwork between PGP and PIN proteins determines the direction auxin moves and, therefore, how the plant develops, Murphy said. In plants, shape, height and bending in response to light and gravity are largely determined by the direction and amount of auxin moving through their tissues.

Murphy and his collaborators on the Plant Journal study found that PGP1 and PGP19 move the hormone out of cells.

In the November Plant Cell report, Murphy's research team reported that another P-glycoprotein, PGP4, functions in the opposite direction, providing the boost needed to import the hormone auxin into cells and to increase the amount transported.

"With these t
'"/>

Source:Purdue University


Page: 1 2 3

Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Plants, animals share molecular growth mechanisms
3. Plants respond similarly to signals from friends, enemies
4. Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering
5. Plant hemoglobins: Oxygen handlers critical for nitrogen fixation
6. Plants defy Mendels inheritance laws, may prompt textbook changes
7. Whats really making you sick? Plant pathologists offer the science behind Sick Building Syndrome
8. Plant Sacrifices Cells to Fight Invaders
9. Breakthrough System for Understanding Ocean Plant Life Announced
10. Plant pathologists evaluate eco-friendly alternatives to methyl bromide
11. Study: Plants use dual defense system to fight pathogens
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Plant gene related cancer treatment may foster new oncology drugs

(Date:5/7/2015)... , May 7, 2015 ... sensors, FPC1022 and FPC1035, FPC,s smallest touch fingerprint ... are mainly considered for integration on the backside ... smartphone OEMs increased possibilities to integrate touch fingerprint ... size also improves possibilities for module manufacturers to ...
(Date:4/27/2015)... more than four decades, AUVSI,s Unmanned Systems ... event for the unmanned land, sea, and air industries. ... local, national, or trade news organization interested in gathering ... applications of unmanned technologies. The conference will explore the ... and how it will soon impact the lives of ...
(Date:4/21/2015)... BURNABY, Canada , April 21, 2015 ... spending and evolving government policies are boosting access control ...   According to a recently published report ... & Opportunities, 2020 ", the access control systems market ... to nearly USD1.2 billion by 2020.The access control systems ...
Breaking Biology News(10 mins):FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3
... a glance, DNA is a rather simple sequence of A, ... histone proteins into an amalgam called chromatin, a more complex ... and H4can either coil DNA into inaccessible silent regions or ... small chemical flags, such as methyl groups, affect whether histones ...
... as they grow older, according to a new study in ... growth accelerates as they age suggests that large, old trees ... the atmosphere. , Richard Condit, staff scientist at the ... from more than 600,000 trees belonging to 403 species. "Rather ...
... one of the most deadly infectious diseases in the world ... every year, and the recent emergence of parasites resistant to ... Researchers are now onto a new strategy to defeat drug-resistant ... ACS Chemical Biology . Christine Hrycyna, Rowena ...
Cached Biology News:Next-gen reappraisal of interactions within a cancer-associated protein complex 2Next-gen reappraisal of interactions within a cancer-associated protein complex 3
(Date:6/2/2015)... June 2, 2015   Intrexon Corporation ... biology, announced today the appointment of Olivier ... Consumer Sector.  Mr. Jarry will lead the expansion ... and applications for consumer markets.  ... of experience in leading global life sciences and ...
(Date:6/2/2015)... June 2, 2015  RXi Pharmaceuticals Corporation ... focused on discovering and developing innovative therapies ... ophthalmology, today announced that Dr. Pamela Pavco ... at the 23 rd World Congress ... will include in-depth presentations by world-class clinicians ...
(Date:6/2/2015)...  Alere Inc. (NYSE: ALR ), a ... House Antibiotic Stewardship Forum today to announce a ... the President,s National Action Plan to Combat Antibiotic-Resistant ... measurable goals and objectives over the next five ... protect their patients through antibiotic stewardship, slow the ...
(Date:6/2/2015)... Junction, AZ (PRWEB) June 02, 2015 ... light microscope technology, Yancy Corporation is enabling ... any desired material and biological sample, displaying the full ... electron bonds between atoms. , Jeff Porter, Co-Founder of ... physics are just that – rare. They come once ...
Breaking Biology Technology:Intrexon Announces New Sector Leader 2Intrexon Announces New Sector Leader 3RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 2RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 3RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 4Alere Announces Broad Initiatives to Help Combat Antibiotic Resistance during White House Antibiotic Stewardship Forum 2Scientists Eying Rare Discovery Of New Physics & Light Microscope Technology 2
... featured in oral presentation ... TSX Exchange Symbol: ... is pleased to announce that tomorrow it is making,an oral ... at the International Atherosclerosis Society (IAS),Workshop on HDL. The presentation ...
... A hybrid device combining force and fluorescence developed ... possible the accurate detection of nanometer-scale motion of biomolecules ... energy transfer and an optical trap, we now have ... a biomolecule at an extremely low applied force, said ...
... IRVINE, California, October 11 IsoTis, Inc.,(NASDAQ: ISOT ... adjourned the special meeting of stockholders it called to ... IART ) ("Integra") pursuant to an agreement and ... The special meeting of stockholders was held at 9 ...
Cached Biology Technology:Resverlogix is Presenting at IAS HDL Workshop 2New force-fluorescence device measures motion previously undetectable 2New force-fluorescence device measures motion previously undetectable 3IsoTis Adjourns Special Meeting to October 23, 2007 2IsoTis Adjourns Special Meeting to October 23, 2007 3IsoTis Adjourns Special Meeting to October 23, 2007 4