Navigation Links
Plant gene related to cancer treatment may foster new oncology drugs

they found that other PGP proteins move auxin into cells.

"Auxin molecules essentially are pulled through the cell membrane by PGP transport proteins," Murphy said. "It's an energetic process that happens like pulling a rope through something sticky."

Both the multi-drug resistant PGPs in people and plants are part of a large family of proteins, called ATP-binding cassette (ABC) proteins, that act as delivery trucks to detoxify cells, send messages from cell to cell to influence biochemical reactions, and to regulate those reactions. The ABC proteins are so named because they must bind with ATP, the main cell energy source, in order to fulfill their mission.

The best known member of another class of transport proteins, PIN1, also may be a transporter, but appears to function primarily as an aide rather than the delivery truck for auxin transport, Murphy said. This finding revealed that PINs and PGPs may function together in long-distance auxin transport, according to the Plant Journal article. Named for the pin-shaped appearance of the mutant originally used to identify the gene that directs the activities of PIN1, these proteins are members of the major protein family, called facilators, that aid processes such as hormone transport.

Recent evidence suggests that teamwork between PGP and PIN proteins determines the direction auxin moves and, therefore, how the plant develops, Murphy said. In plants, shape, height and bending in response to light and gravity are largely determined by the direction and amount of auxin moving through their tissues.

Murphy and his collaborators on the Plant Journal study found that PGP1 and PGP19 move the hormone out of cells.

In the November Plant Cell report, Murphy's research team reported that another P-glycoprotein, PGP4, functions in the opposite direction, providing the boost needed to import the hormone auxin into cells and to increase the amount transported.

"With these t
'"/>

Source:Purdue University


Page: 1 2 3

Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Plants, animals share molecular growth mechanisms
3. Plants respond similarly to signals from friends, enemies
4. Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering
5. Plant hemoglobins: Oxygen handlers critical for nitrogen fixation
6. Plants defy Mendels inheritance laws, may prompt textbook changes
7. Whats really making you sick? Plant pathologists offer the science behind Sick Building Syndrome
8. Plant Sacrifices Cells to Fight Invaders
9. Breakthrough System for Understanding Ocean Plant Life Announced
10. Plant pathologists evaluate eco-friendly alternatives to methyl bromide
11. Study: Plants use dual defense system to fight pathogens
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Plant gene related cancer treatment may foster new oncology drugs

(Date:12/17/2014)... Dec. 15, 2014 Research and Markets ... of the "Samsung Galaxy S5 - Home ... to their offering. ... different sensing technology than the iPhone 5S, Samsung ... in its product. The Galaxy S5 ...
(Date:12/17/2014)... Dec. 15, 2014  HITLAB SM announced ... (GCP) audit to confirm its adherence to current ... accomplishment enables HITLAB to conduct regulated smart device ... principles for patient safety and research quality. ... access, quality, and delivery with innovative technology," said ...
(Date:12/17/2014)... DUBLIN , Dec. 16, 2014 Research ... announced the addition of the "Global Chemical ... http://photos.prnewswire.com/prnh/20130307/600769 ... is the increasing demand for medical sensors in ... patient data for quick and correct diagnosis during ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... Wash. Richard D. Smith, Battelle Fellow at the U.S. ... one of 50 outstanding leaders in the 2007 Scientific American ... 50 key contributors in science and technology. Smith shared ... with a colleague from UCLAs David Geffen School of Medicine, ...
... Haven, Conn.A genetic mutation expands lesions in the aorta ... of the arteries, according to a study by Yale ... researchers found that mice engineered without the Akt1 gene ... signs of aortic atherosclerosis compared to their littermates. And, ...
... of space activities, a silent revolution is taking place ... the first human-rated spacecraft to be launched from Europe,s ... m3 pressurised module of the largest, most complex automated ... closed, fulfilling the most stringent rules of human spaceflight. ...
Cached Biology News:PNNL's Richard Smith named to prestigious Scientific American 50 list of outstanding leaders 2Final preparations for first human-rated spacecraft to be lauched from Europe's Spaceport 2Final preparations for first human-rated spacecraft to be lauched from Europe's Spaceport 3
(Date:12/19/2014)... -- Decision Resources Group finds that the Latin American ... compound annual growth rate through 2023. This is primarily ... increasing adoption of dental implants. Growing aesthetic consciousness in ... demand for dental biomaterials because they can improve the ... Other key findings from Decision Resources Group,s coverage ...
(Date:12/19/2014)... 18, 2014 LayerBio is an MIT ... wound care. The National Eye Institute (NEI) at the ... Phase I SBIR grant to develop a drug-eluting intraocular ... most common cause of vision loss in people over ... According to Dr. Ken Mandell, LayerBio’s Founder and CEO, ...
(Date:12/19/2014)... 2014 In contrast to traditional LED ... various colors, Valoya uses proprietary LED technology to incorporate ... possible uniformity which is critical in low proximity installations. ... accuracy throughout its lifetime which is up to four ... , "The investment cost was clearly higher when compared ...
(Date:12/19/2014)... -- Egenix, Inc. is pleased to announce that Lionel ... to succeed Donald Fresne ; Mr. Fresne has also ... member of the Board.  In recognition of the many contributions ... almost twenty years, the Board designated Mr. Fresne as Chairman ... a Search Committee to find a suitable replacement with Biotech ...
Breaking Biology Technology:Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3LayerBio Awarded NIH Grant to Develop a Drug Delivery Device for Cataract Surgery 2
... said this week that she would like Wisconsin to double ... the Act 255 program. , ,In an interview, Burke said ... but she would like to double the tax credits from ... Act 255, which had bipartisan support, the state made available ...
... Wis. Small Tree Communications said it ... Chippewa Valley Angel Investing Network , which invested $445,000 in ... drivers and other products for Apple's Mac OS X. It ... million in funding has been allocated for the company to ...
... Wis. Fiserv, Inc. , the Brookfield-based provider ... Wisconsin companies to make the annual Fortune 500 ... , ,Fiserv, which reported $4.1 billion in annual revenue ... 488 after ranking 510th last year. The annual ranking will ...
Cached Biology Technology:Burke would like to double Act 255 angel tax credits 2