Navigation Links
Plant gene related to cancer treatment may foster new oncology drugs

Two proteins involved in the process that controls plant growth may help explain why human cells reject chemotherapy drugs, according to an international team of scientists.


Researchers from Purdue University and Kyoto University in Japan have shown for the first time that proteins similar to multi-drug resistant proteins in humans move a plant growth hormone into cells, said Purdue plant cell biologist Angus Murphy. Because plant proteins called P-glycoproteins (PGPs) are closely related to human P-glycoproteins that impact chemotherapy effectiveness, discovery of methods to control the plant protein's activity may aid in development of therapies to reduce drug dosages administered to cancer patients, Murphy said.

Murphy is corresponding author of the study published in the November issue of Plant Cell. He also is corresponding author of a related article published in October's Plant Journal.

"Results of this research will give us a better idea of the functioning of the multi-drug resistance process in which human cancer cells reject anticancer treatments," Murphy said.

Results of the two studies suggest a previously unknown relationship between two protein families involved in this process, he said. Working together, the proteins apparently move molecules of the plant growth hormone auxin through cell walls. In humans, related proteins rid cells of toxins such as cancer drugs.

"The findings of these two studies have important implications for biomedicine because we now can identify the parts of these proteins that determine whether cells take up or throw off different molecules, such as cancer drugs," Murphy said.

In the Plant Journal study, Murphy and his collaborators at the University of Zurich showed for first time that PGP1, a P-glycoprotein from the commonly used experimental plant Arabidopsis, directly transports auxin out of plant cells and also out of yeast and mammalian cells. In the Plant Cell study,
'"/>

Source:Purdue University


Page: 1 2 3

Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Plants, animals share molecular growth mechanisms
3. Plants respond similarly to signals from friends, enemies
4. Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering
5. Plant hemoglobins: Oxygen handlers critical for nitrogen fixation
6. Plants defy Mendels inheritance laws, may prompt textbook changes
7. Whats really making you sick? Plant pathologists offer the science behind Sick Building Syndrome
8. Plant Sacrifices Cells to Fight Invaders
9. Breakthrough System for Understanding Ocean Plant Life Announced
10. Plant pathologists evaluate eco-friendly alternatives to methyl bromide
11. Study: Plants use dual defense system to fight pathogens
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Plant gene related cancer treatment may foster new oncology drugs

(Date:10/31/2014)... steps involved in programmed cell death, offering new targets ... neurodegenerative diseases. , The research teams from the ... the three-dimensional structure of a key cell death protein ... it causes cell death. Their studies were published in ... Proceedings of the National Academy of Sciences . ...
(Date:10/31/2014)... 2014  HITLAB SM , a healthcare innovation ... inaugural HITLAB Innovators Summit SM on December ... will partner with the Clinton Foundation,s Health Matters ... Columbia Business School Alumni Club of ... and Operations Research, bringing together leaders in healthcare ...
(Date:10/30/2014)... When most animals begin life, cells immediately begin accepting ... organ. However, mammals, including humans, are special. The cells ... choice – to become the protective placenta or to ... critical first step that research from Michigan State University ... current issue of PLOS Genetics , ...
Breaking Biology News(10 mins):A matter of life and death: Cell death proteins key to fighting disease 2HITLAB Announces Inaugural HITLAB Innovators Summit 2HITLAB Announces Inaugural HITLAB Innovators Summit 3Identifying the source of stem cells 2
... from brake linings and mining operations can affect salmon ... a Washington State University researcher. Jenifer McIntyre found the ... they won,t detect a compound that ordinarily alerts them ... is not getting the information it needs to make ...
... Switzerland. Research to be presented at the Annual Meeting of ... foremost society for research into all aspects of eating and ... reduces the quality of sleep in rats. Using radio-telemetry, ... consumed a high fat diet for 8 weeks. Compared to ...
... debilitating illnesses one can develop. Currently, the disease afflicts 6.5 ... to between 11 and 16 million, or 1 in 85 ... one to grow forgetful, confused and, eventually, catatonic. Recently approved ... consensus on the underlying mechanism of the disease. "We ...
Cached Biology News:Copper making salmon prone to predators 2Small molecule may play big role in Alzheimer's disease 2Small molecule may play big role in Alzheimer's disease 3Small molecule may play big role in Alzheimer's disease 4
(Date:10/30/2014)... -- Isis Pharmaceuticals, Inc. (NASDAQ: ISIS ), the ... a company overview at the Nomura Biotechnology Conference on Thursday, ... Boston, MA. A live webcast of ... section of the Company,s website, www.isispharm.com .  A replay ... and will be archived for a limited time. ...
(Date:10/30/2014)... challenges in the development of quantum technologies has been ... paper published today (28 October) in Nature Communications ... make a new type of flexibly designed microscopic trap ... sensors and specialised superfast computers, often depend on harnessing ... trapping these tiny particles are hugely problematic because of ...
(Date:10/27/2014)... The new research report, “Gas ... Medium), Sub-type (Primary & Secondary), and End-User (Transmission ... & Power Generation) - Trends and Forecasts to ... analysis and forecasting of the market size. , ... 52 Figures spread through 146 Pages and in-depth ...
(Date:10/27/2014)... , Oct. 27, 2014 Kalorama Information ... recent Ebola concern in the United States ... virus.  The healthcare market researcher said the FDA,s Emergency Use ... vitro diagnostic tests for the detection of the Ebola ... proved useful.  Kalorama routinely assess the IVD industry and ...
Breaking Biology Technology:Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 3Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 4Kalorama: PCR The Go-to Test in Ebola Fight 2Kalorama: PCR The Go-to Test in Ebola Fight 3
... October 6, 2010 ... ... var shortURL ... longUrl, so we need to grab the first one. for (var r in data.results) { first_result = ...
... tiaras to anklets are treasures but these gemstones inside ... Reserve University researchers are building implants made of diamond ... and electrical changes in the brain of patients suffering ... movement in the paralyzed. The work of Heidi ...
... Oct. 4 issue of the high-impact journal, Applied ... the University of Cincinnati and start-up company Gamma Dynamics ... electronic devices. This patent-pending electrofluidics breakthrough by the ... partner companies Gamma Dynamics, Dupont and Sun Chemical follows ...
Cached Biology Technology:Elsevier Introduces Article-Based Publishing to Increase Publication Speed 2Elsevier Introduces Article-Based Publishing to Increase Publication Speed 3Elsevier Introduces Article-Based Publishing to Increase Publication Speed 4Elsevier Introduces Article-Based Publishing to Increase Publication Speed 5Elsevier Introduces Article-Based Publishing to Increase Publication Speed 6Elsevier Introduces Article-Based Publishing to Increase Publication Speed 7Elsevier Introduces Article-Based Publishing to Increase Publication Speed 8Gem of an idea: A flexible diamond-studded electrode implanted for life 2Gem of an idea: A flexible diamond-studded electrode implanted for life 3Breakthrough e-display means electronics with high speed, high readability and low power usage 2Breakthrough e-display means electronics with high speed, high readability and low power usage 3Breakthrough e-display means electronics with high speed, high readability and low power usage 4
Rabbit polyclonal to Warfarin ( Abpromise for all tested applications). Antigen: Chemical / Small Molecule conjugated to KLH...
Rabbit polyclonal to MA2 ( Abpromise for all tested applications). entrezGeneID: 10687 SwissProtID: Q9UL42...
Mouse monoclonal [YPF19] to Yersinia pestis ( Abpromise for all tested applications)....
DDO Immunogen: DDO (NP_003640, 270 a.a. ~ 370 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Biology Products: