Navigation Links
Plant-derived vaccines safeguard against deadly plague

stably produce high levels of proteins, called antigens, which conferred immunity against the plague.

"This current work represents a new direction in our research because we've come to the realization that plants also have the potential for the production of antigens that can be purified and delivered by typical intramuscular or subcutaneous injections -- the way most vaccines are normally given," said Mason, an associate professor in the School of Life Sciences. "This new system produces really high levels of antigens in relatively short periods of time."

The researchers modified tobacco plants to make high levels of the plague antigens F1, V and a combination of the two, a so-called F1-V fusion antigen. All are known to be important for the plague bacteria to produce its toxic effects.

The antigens were purified from the plants and injected into guinea pigs. Testing using an aerosolized form of plague was performed by Chad Roy and Robert Webb at the U.S. Army Medical Research Institute of Infectious Disease at Fort Detrick, Maryland. This project was also the first comparison study designed to test more than one kind of antigen during the same challenge.

"The idea with any recombinant subunit vaccine is that you can pick and choose selective antigens that can confer protection and limit the potential for adverse reaction," said Mason.

More than half the vaccinated animals survived the challenge with all forms of the antigen, and guinea pigs vaccinated with V antigen alone had the highest survival rates.

"This study provided validation of our plant expression system, that it can produce the bacterial antigens in a native form that will allow for an appropriate immune response against a bacterial pathogen." Mason.

Critical to the success of the study was a collaboration set up with Anatoli Giritch, Victor Klimyuk and Yuri Gleba, who originally developed the plant expression system at Icon Genetics, lo
'"/>

Source:Arizona State University


Page: 1 2 3

Related biology news :

1. Plant-derived molecules, genetic manipulation point to future chemoprevention methods
2. Live vaccines more effective against horse herpes virus
3. Designing vaccines by computer
4. Improving the potential of cancer vaccines
5. Report focuses on challenges to unlocking future promise of vaccines
6. Medical experts: US unlikely to have enough vaccines to stop avian flu
7. High-dose flu vaccines appear to safely boost immunity in elderly
8. Handling HPV vaccines and screening: The views of 100 authors
9. Protecting virus offers instant flu protection and converts flu infections into their own vaccines
10. Super enzyme may lead way to better tumor vaccines
11. Cellulose nanocrystal research could lead to new vaccines, computer inks
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Plant derived vaccines safeguard against deadly plague

(Date:6/16/2015)... , June 16, 2015 Fingerprint ... touch fingerprint sensors in the company,s portfolio from one of ... are planned to mainly take place during the third quarter ... Asia . Jörgen Lantto, CEO ... of    the   growing interest from smartphone OEMs in ...
(Date:6/15/2015)... YORK , June 15, 2015 ... today from Telstra reveals the majority of US consumers using ... them via biometrics, such as fingerprint and voiceprint, instead of ... According to Telstra,s " Mobile Identity   - ... " report, with smartphones now the primary channel used ...
(Date:6/11/2015)... 11, 2015 Daon, a global leader ... its IdentityX Mobile Authentication Platform v4.0 has been ... is an industry consortium launched in 2013 to ... stronger authentication.  In order to receive certification, a ... series of tests that measure compliance and ensure ...
Breaking Biology News(10 mins):FPC Receives Order for Touch Fingerprint Sensors of 375 MSEK 2One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 2One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 4Daon's IdentityX Mobile Authentication Platform One of First Products to be Certified by FIDO Alliance 2
... Group, Inc. (OTC Bulletin Board: MDXG ), ... biomaterial-based products, announced today that its results for the ... and Company guidance will be released after the closing ... timing of the earnings announcement allows MiMedx time to ...
... the oocysts from the Cryptosporidium genus and cysts ... greatest public health problems in water supply, because these parasites ... Hermida, a scientist at the Galician Institute for Food Quality ... A team led by this researcher took 232 water samples ...
... at IRB Barcelona have completed the 3D structural sequence ... substances between the extra and intracellular milieu. This finding ... occur in these relevant proteins during basic cell processes, ... cell volume, and nerve transmission. The exchange ...
Cached Biology News:MiMedx Group, Inc. Announces Release Date for 2010 Fourth Quarter and Full Year Results 2Parasitic protozoons survive waste water and drinking water treatment plants in Galicia 2Researchers achieve a full film frame of a family of proteins essential for cell function 2
(Date:6/25/2015)... June 25, 2015 Last June, a dedicated global ... the virus using large-scale genome sequencing. Their research, which was ... in the journal Cell (Park 2015) , ... over seven months of the recent Ebola outbreak. ... draft, data, workflows, and full edit history of the paper ...
(Date:6/25/2015)... , June 25, 2015 Current asthma ... immune cells or by dilating the airways, can ... Children,s Hospital, Brigham and Women,s Hospital and Harvard ... controlling asthma: targeting certain sensory nerve endings in ... Reporting online in the journal Neuron ...
(Date:6/25/2015)... ... June 25, 2015 , ... Students ... enjoy (8) new chemistry laboratories, each exclusively using filtered fume hoods that feature ... installing the (49) filtered fume hoods needed for their Organic, Inorganic, Analytical, and ...
(Date:6/25/2015)... YORK , June 25, 2015  The Galien ... Professor of Genome Sciences and Medical Genetics at the ... 2015 Pro Bono Humanum Award at the ninth annual ...   The Pro Bono Humanum ... King is the first woman recipient of the award.   ...
Breaking Biology Technology:Open Science Takes Major Leap Forward 2Targeting Nerve Endings To Curb Allergic Asthma 2Targeting Nerve Endings To Curb Allergic Asthma 3Targeting Nerve Endings To Curb Allergic Asthma 4Targeting Nerve Endings To Curb Allergic Asthma 5This Summer Erlab Completes the Largest Installation of Filtered Fume Hoods in the World 2The Prix Galien USA Awards Committee Selects Professor Mary-Claire King as 2015 Pro Bono Humanum Honoree 2The Prix Galien USA Awards Committee Selects Professor Mary-Claire King as 2015 Pro Bono Humanum Honoree 3
... 11 CV Therapeutics,Inc. (Nasdaq: CVTX ) today ... 2007 after the market closes on Tuesday, November 6,2007. ... p.m. EST,1:30 p.m. PST, on the company,s website. ... the Company,s website at, http://www.cvt.com and go to ...
... - The Board of,Directors of Immunotec Inc. is ... A. Northrop as President and Chief Executive Officer, ... Board of Directors of Immunotec Inc., Mr. Northrop ... success in rapid growth,situations, Mr. Northrop has impressive ...
... an Eden Prairie-,based molecular diagnostics service and technology company, ... its CFO, and Elizabeth A. Skinner,as VP - Legal, ... of Edwin Watts Golf, and has previously,served as VP ... Allied Signal,Aerospace, and corporate controller of NCR Corporation. He ...
Cached Biology Technology:CV Therapeutics To Announce 2007 Third Quarter Financial Results on Tuesday, November 6, 2007 2Immunotec Inc. announces appointment of President & CEO James A. Northrop 2Access Genetics Announces New Executive Appointments 2
HybriWell seals securely to a microscope slide surface in seconds to enclose single or multiple specimens in a small reagent volume and eliminate evaporation....
Comp Dim: chamber diam. depth 20 2.8 mm chamber maximum volume 720 μL...
... Human IgM Assay Kit to address the ... assay for Human IgM that eliminates the ... a simple mix-and-read assay that allows the ... ng/ml in approximately 30 minutes. The Pierce ...
AC input: 230 V...
Biology Products: