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Plant-derived molecules, genetic manipulation point to future chemoprevention methods

tric oxide expression, curbing proliferation and inducing apoptosis in human lung cancer cells.

They tested CDDO-MA and LG100268 on mice for 20 weeks. CDDO-MA and 268 reduced the number of lung tumors to 9.1 in the group fed CDDO and to 7.4 in the 268-fed group, compared to 15.5 in the control group. These tumors were smaller, too: 43 percent of tumors in CDDO-fed mice and 28 percent of tumors in the 268-fed group were less than 0.5 mm in diameter, compared to only four percent in the control groups.

CDDO-ME and CDDO-EA, other synthetic forms of CDDO, also reduced tumors. After 15 weeks on a diet of the CDDO-ME triterpenoid, tumors numbered only 7.4, compared to 15.9 in the control mice. For mice on CDDO-EA, tumors were reduced to 7.8. No tumors in these groups were larger than 1 mm in diameter, while 20 percent of tumors in the control mice averaged more than this size. In fact, between 63 and 70 percent of tumors were less than 0.5 mm in diameter.

The research suggests the potential for these compounds in preventing lung cancer, and points to the need for clinical trials to test their effectiveness in humans.

The triterpenoid, CDDO-methyl ester, and the rexinoid, LG100268, synergize in the prevention of mammary tumors in a mouse model of estrogen receptor-negative breast cancer

Triterpenoids and the rexinoid experimental drug LG100268 were also effective in combination against breast cancer development more than either compound individually, the Dartmouth research team found.

Liby and her colleagues found that the synthetic triterpenoid CDDO-ME and the drug LG100268 eliminated tumors in mice that were fed the compounds. The work bolsters the potential for these drugs as a chemopreventive agent for an increasing range of cancers.

"We previously reported that the rexinoid LG100268 and another potential drug, Afzoxifene, which modulates the estrogen receptor, synergize in the prevention and treat
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Source:American Association for Cancer Research


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