Navigation Links
Placenta Is A Rich Source Of Blood Stem Cells

Researchers at Children's Hospital Boston and the Dana-Farber Cancer Institute report a surprising finding about embryonic development: the blood system begins to form not only in the embryo itself, but also in the placenta, the organ that nurtures the baby in utero.

Meticulous experiments in mice revealed that the placenta harbors a large supply of hematopoietic (blood-forming) stem cells. These cells, which appear very early in development, are able to generate more blood stem cells and can give rise to a complete blood system when transplanted into an adult. Unlike other sites where blood stem cells are found during embryonic development, such as the liver, the stem cells in the placenta can increase in number without giving rise to mature, specialized cells.

''There must be something unique about the placenta that nurtures blood stem cells and discourages them from differentiating,'' says Dr. Stuart Orkin, a Howard Hughes Medical Institute investigator at Children's and DFCI, and a senior investigator of the study. ''If we figure out what's special about the placental environment, we may learn how to grow blood stem cells in large numbers for clinical application.''

Blood stem cells are used in treating blood cancers like leukemia and other blood diseases, and in patients receiving transplants, but growing them in quantity is difficult. The cells don't multiply readily in the laboratory, so they must be harvested from bone marrow by needle aspiration, a painful procedure, or coaxed into the blood and then collected. Both methods yield only a limited number of blood stem cells.

For more than a decade, scientists have believed that blood stem cells are made only in the embryo itself, within the region of the developing aorta. No role was suspected for the placenta, which has been seen as simply a place for nutrient exchange and waste removal between mother and fetus. But rather than merely providing nutrients, Orkin says, the placent a may also provide an ''infusion'' of blood stem cells to the fetus.

''This research reveals a new organ for blood development,'' Orkin says. ''It is surprising that this role for the placenta has been overlooked for so many years.''

The study, published in the March issue of the journal Developmental Cell, found that blood stem cells appeared in the placenta early, with numbers peaking mid-gestation. Only the fetal liver, where blood stem cells are known to expand tremendously, had greater numbers of blood stem cells.

Children's Hospital Boston is home to the world's largest research enterprise based at a pediatric medical center, where its discoveries have benefited both children and adults for over 136 years. More than 500 scientists, including eight members of the National Academy of Sciences, nine members of the Institute of Medicine and 10 members of the Howard Hughes Medical Institute comprise Children's research community. Founded in 1869 as a 20-bed hospital for children, Children's Hospital Boston today is a 325-bed comprehensive center for pediatric and adolescent health care grounded in the values of excellence in patient care and sensitivity to the complex needs and diversity of children and families. Children's also is the primary pediatric teaching affiliate of Harvard Medical School. For more information about the hospital visit: http://www.childrenshospital.org/research.


'"/>

Source:Children's Hospital Boston


Related biology news :

1. Source of molecular triggers in cutaneous T cell lymphoma identified
2. Finding Cures For Tropical Diseases: Is Open Source An Answer?
3. Open Source Biotechnology alliance for international agriculture
4. Source of crucial immune cell in the skin discovered
5. Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells
6. White Blood Cell Waste Disposal System Plays Critical Regulatory Role
7. Mystery Blood Vessel Disorder Implicated In Mini Strokes
8. Infants with Rare Genetic Disease Saved By Cord Blood Stem Cells
9. Young Blood Revives Aging Muscles, Stanford Researchers Find
10. Stem Cells to Solve the Blood Shortage Problem?
11. Blood flow in brain takes a twist, affecting views of Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/15/2016)... Research and Markets has announced ... 2016-2020,"  report to their offering.  , ... global gait biometrics market is expected to grow ... 2016-2020. Gait analysis generates multiple variables ... to compute factors that are not or cannot ...
(Date:3/31/2016)... March 31, 2016  Genomics firm Nabsys has completed ... Barrett Bready , M.D., who returned to the ... original technical leadership team, including Chief Technology Officer, ... Development, Steve Nurnberg and Vice President of Software and ... company. Dr. Bready served as CEO of ...
(Date:3/22/2016)... and SANDY, Utah , March ... operates the highest sample volume laboratory in ... and UNIConnect, leaders in clinical sequencing informatics and molecular ... of a project to establish the informatics infrastructure for ... NSO has been contracted by the Ontario Ministry ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ... April 27, 2016 , ... Global Stem Cells Group ... Ross is the founder of GSCG affiliate Kimera Labs in Miami. , In 2004, ... hematopoietic stem cell transplantation for hematologic disorders and the suppression of graft vs. host ...
(Date:4/26/2016)... , ... April 27, 2016 , ... ... Lewis Roca Rothgerber Christie LLP as an associate in the firm’s Intellectual Property ... international electrical, mechanical and electromechanical patent applications. He has an electrical engineering and ...
(Date:4/26/2016)... San Francisco, CA (PRWEB) , ... April 26, 2016 , ... ... RPO division for Adecco RPO, signing the first multi-million dollar, multi-year managed services contract ... are delighted to have Michael join our leadership team,” said John Younger, founder of ...
(Date:4/26/2016)... VIENNA and ... The prize recognizes the innovation capabilities ... innovations that will benefit patients and laboratory diagnostics ... ) , Norma Instruments , ... setting products in the field of hematology, announced ...
Breaking Biology Technology: