Navigation Links
Pinpointing the cause of a neurodegenerative disorder

New understanding of spinocerebellar ataxiaResearchers have discovered how the abnormal repetition of a genetic sequence can have disastrous consequences that lead to the death of neurons that govern balance and motor coordination. The studies bolster the emerging theory that neurodegenerative disorders can be caused by having extra copies of a normal protein, not just a mutated one.

People who are afflicted with the rare neurodegenerative disorder spinocerebellar ataxia type 1 (SCA1) suffer damage to cerebellar Purkinje cells caused by a toxic buildup of the protein Ataxin-1. Researchers knew that SCA1, Huntington's disease and other related disorders arise because of a "genetic stutter," in which a mutation causes a particular gene sequence to repeat itself. These abnormal genetic repeats cause the resulting proteins to contain unusually long repetitive stretches of the amino acid glutamine.

The new findings, which are published in the August 26, 2005, issue of the journal Cell, provide a molecular explanation for Ataxin-1's assault on cerebellar Purkinje cells.

The findings should help to understand a range of diseases, including Huntington's disease, which are caused by an abnormal number of repetitive gene sequences. The discovery may also offer a new conceptual approach to understanding the pathology of Parkinson's disease and Alzheimer's disease, according to Huda Y. Zoghbi, a Howard Hughes Medical Institute investigator at the Baylor College of Medicine.

People with polyglutamine repeat disorders suffer severe degeneration in particular groups of neurons that vary depending on the type of disease. In SCA1, for example, the buildup of Ataxin-1 damages the cerebellar Purkinje cells. As a result of the damage, people with SCA1 lose balance and motor coordination. Loss of muscle control worsens until patients can no longer eat or breathe.

"We had known that the expansion of the glutamine tract within Ataxin-1 probably inte
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3

Related biology news :

1. Pinpointing a culprit molecule in Alzheimers disease
2. Dysentery uses sword and shield to cause infection
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. BRCA1 causes ovarian cancer through indirect, biochemical route
5. Scientists decipher genome of fungus that can cause life-threatening infections
6. Researchers discover molecule that causes secondary stroke
7. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
8. NASA study finds snow melt causes large ocean plant blooms
9. Emergence of cancer as major cause of childhood death in developing countries is not being adequately addressed
10. UNC launches study of liver injury caused by drugs
11. First technology to remove prions that cause vCJD from blood launched
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Pinpointing the cause neurodegenerative disorder

(Date:12/10/2014)... , Dec. 9, 2014 CIE San ... catalyst that provides the connective tissue that enhances care ... them to easily share client-level information; earned a second ... expand to organizations serving seniors aging in community and; ... partner on December 11 th 4-6p. ...
(Date:12/10/2014)... 9, 2014     ...   Jifflenow, a ... solutions for business-to-business (B2B) events, today announced a ... mobile near-field communication (NFC), Bluetooth low energy (BLE), ... http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow will integrate its ...
(Date:12/5/2014)... -- Tute Genomics, a leader in cloud-based solutions for genome ... led by UK-based Eurovestech. Peak Ventures and a number ... "We are at a pivotal time in ... seeks new approaches for the diagnosis, treatment and prevention ... and CEO of Tute Genomics. "One of the main ...
Breaking Biology News(10 mins):Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3
... say they have discovered a cause-and-effect relationship between ... believed to be independent of one another. ... better drugs to treat the cognitive dysfunction associated ... ,Researchers have long studied the role played in ...
... Rice University and Lockheed Martin reported this month that ... from a single silicon wafer. The process uses simple ... lithium-ion batteries, laying the groundwork for longer-lasting, more powerful ... vehicles. The work led by Sibani Lisa Biswal, ...
... up their arms, clench their fists and grimace after a ... the same across cultures, a new study suggests. New findings ... Human Behavior suggest this victory pose signals feelings of ... "We found that displays of triumph include different behaviors ...
Cached Biology News:Johns Hopkins researchers link 2 biological risk factors for schizophrenia 2Toughened silicon sponges may make tenacious batteries 2Victory stance may be a universal gesture of triumph -- not pride -- study suggests 2
(Date:12/24/2014)... Pipette.com announces their Holiday in ... submit their #HolidayInTheLab pictures for a chance to win ... For those struggling to think of a holiday gift ... the Lab Contest provides the ideal holiday presents. The ... send pictures of their chemistree, holiday sweaters, as well ...
(Date:12/24/2014)... Dec. 23, 2014 Vermillion, Inc. (Nasdaq: ... gynecologic disease, announced today that investors including Oracle ... Fund LLC and several Vermillion directors have agreed ... of Vermillion,s common stock and warrants to purchase ... private placement.  Under the terms ...
(Date:12/24/2014)... 2014 Sigma-Aldrich Corporation (NASDAQ: ... under the Hart-Scott-Rodino Antitrust Improvements Act (HSR Act) ... 22, 2014, thereby completing the U.S. HSR Act ... of the Company by Merck KGaA, Darmstadt, Germany.  ... condition to closing the transaction, which remains subject ...
(Date:12/24/2014)... NEW YORK , Dec. 23, 2014  NeuroLifeSciences ... of mazindol in children with attention deficit/hyperactivity disorder published ... 2014 . The paper, titled "Pilot ... deficit/hyperactivity disorder" ( Konofal et al, Drug ... 2014 ) shows that mazindol might be an ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3
... - FDA Targets January 11, 2008 as Action Date, ... SPPI ) today announced that the amendment to,the ... LFA),for injection has been accepted by the U.S. Food ... 2008 as its action date regarding,the approval of the ...
... Asset Exchange Agreement, COPENHAGEN, September 13 ... an asset exchange agreement with,Medarex, Inc. Under the ... to HuMax-Inflam(TM)/MDX-018, which targets IL-8, and Medarex will,receive ... Genmab and,Medarex will release to each other all ...
... UPTON, NY Scientists at the U.S. Department of ... for controlling the self-assembly of nanometer and micrometer-sized particles. ... a particles surface, can be used to manipulate the ... of numerous materials that may be of interest ...
Cached Biology Technology:FDA Accepts ISO-Vorin(TM) New Drug Application Amendment Submitted by Spectrum Pharmaceuticals 2FDA Accepts ISO-Vorin(TM) New Drug Application Amendment Submitted by Spectrum Pharmaceuticals 3Genmab Announces Asset Exchange Agreement 2New DNA-based technique for assembly of nano- and micro-sized particles 2
... covers can be used with ... covers for stacking of covered ... for use with automated systems ... and non-ridged, are available for ...
... modular, computer controlled pre-amplifier suitable for a ... electrode input for recording physiological signal such ... a transducer input for use with a ... Additional options include a stimulus artefact clamp ...
SYBR Green Nucleic Acid Dye...
... 384 cap mat made from an inert ... Features 384 split septum caps ... AB-1056) Suitable for PCR when used in ... cyclers Pierceable with standard pipetting equipment ...
Biology Products: