( nside brain cells or outside--intracel...)Pinpointing a culprit molecule in Alzheimer's disease

nside brain cells or outside--"intracellularly." Transgenic mice produced by other researchers have not settled this question, because the peptide was not efficiently secreted by the cells in those mice. However, wrote McGowan and colleagues, "The [Ab] mice that we have developed are clearly distinct from these other "minigene" models in that they efficiently secrete Ab. To date we have little evidence for the accumulation of intracellular Ab in these mice; thus, they provide an excellent tool to study the effects of secreted Ab independently of APP transgenes."

McGowan et al.: "Aß42 is Essential for Parenchymal and Vascular Amyloid Deposition in Mice" Publishing in Neuron, Vol. 47, July 21, 2005, pages 191?99. DOI 10.1016/j.neuron.2005.06.030. www.neuron.org

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Source:Cell Press


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