Navigation Links
Pinpointing a culprit molecule in Alzheimer's disease

One puzzle in Alzheimer's disease (AD) research is why mice engineered to have the abnormal protein underlying the disease in humans show little pathology of the disease. Specifically, such mice are genetically altered to overproduce mutant human amyloid precursor protein (APP). It is this protein that, when clipped by enzymes, produces the amyloid beta (Ab) peptide that clusters into the amyloid plaque that clogs the brain and kills brain cells.

The clipping of APP produces two types of amyloid beta peptide--one 40 amino acid units long (Ab40) and one 42 units long (Ab42). Circumstantial evidence has suggested that Ab42 is the "stickier" of the two forms, and underlies the pathology of the disease.

Now, researchers led by Eileen McGowan and Todd Golde of the Mayo Clinic College of Medicine report in the July 21, 2005, issue of Neuron definitive proof that Ab42 is, indeed, the culprit molecule. In their experiments, they created transgenic mice that overproduced either Ab40 or Ab42 in the absence of overproduction of APP. Thus, they could precisely study the role of each of these molecules in AD pathology.

Their studies of the mice revealed that the Ab40 mice showed little amyloid disease pathology in the animals' brains, while the Ab42 mice showed extensive accumulation of amyloid plaque and resulting neural damage. What's more, when the researchers crossed the Ab42 mice with those producing mutant APP, they saw a massive increase in amyloid deposition that was more than the additive effect of the two mutations.

The researchers pointed out that test tube studies have shown that Ab42 aggregates more readily. "Thus, the simplest explanation for the complete lack of pathology in the [Ab40] mice would be the relative inability of Ab40 to initiate nucleation events capable of promoting amyloid deposition," they wrote.

One question the new transgenic mice might help address, wrote the researchers, is whether Ab peptide does damage i
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Pinpointing the cause of a neurodegenerative disorder
2. Chemists create Superbowl molecule; May lead to better health
3. Key molecule in plant photo-protection identified
4. Inflammatory molecules released by pollen trigger allergies
5. Researchers discover molecule that causes secondary stroke
6. Yale researchers identify molecule for detecting parasitic infection in humans
7. Scientists identify molecule that regulates well-known tumor suppressor
8. Medical molecules designed to respond to visible light that can penetrate tissue
9. Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
10. Chemists synthesize molecule that helps body battle cancers, malaria
11. DNA constraints control structure of attached macromolecules
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Pinpointing culprit molecule Alzheimer disease

(Date:8/21/2014)... study aimed at improving the food intake, health and ... homes is among three projects at the University of ... the Canadian Institutes of Health Research (CIHR). , ... Sciences at Waterloo, and a Schlegel research chair in ... to investigate why many Canadians living in long-term care ...
(Date:8/21/2014)... , Saturday to Wednesday, Oct. 18-22, 2014 , ... W. Harbor Drive, San Diego, CA 92101 , ... and other presentations of the latest research in ... plenary session featuring high-scoring abstracts on rare genetic ... various cancers, and treatment for sun sensitivity (Saturday, ...
(Date:8/21/2014)... Researchers from North Carolina State University have developed a ... The model has applications for creating new materials as ... , "Our new technique allows us to model much ... so much more quickly," says Nan Li, lead author ... student in NC State,s Department of Materials Science and ...
Breaking Biology News(10 mins):Grants will fund landmark aging research at Waterloo 2American Society of Human Genetics 2014 Annual Meeting 2Researchers develop models to study polyelectrolytes, including DNA and RNA 2
... from their homes in Far North Queensland have been ... according to a collaborative research project by The University ... Service. Professor Craig Franklin, from the University,s School ... the northern tip of Australia to reach home ...
... influence nearly every part of children,s daily lives, according ... of the American Journal of Preventative Medicine. The ... of Michigan, reveal that, in most middle and high ... companies give students easy access to sugary beverages. ...
... and world-renowned expert on bird speciation has compiled ... recently published book, Speciation in Birds. Trevor ... evaluates the contributions of sexual selection and natural ... geographical isolation, ecological differentiation and genetic drift. He ...
Cached Biology News:Saltwater crocodiles can find their way home 2Studies: Children obese due to a host of unhealthy pressures 2Studies: Children obese due to a host of unhealthy pressures 3Studies: Children obese due to a host of unhealthy pressures 4University biologist publishes book on bird speciation 2
(Date:8/21/2014)... including DESY scientists has observed tiny quantum vortices in ... the journal Science that the exotic vortices ... It is the first time that the quantum vortices, ... what is known as superfluid helium, have been detected ... says Andrey Vilesov of the University of Southern California, ...
(Date:8/21/2014)... Ireland , August 21, 2014 /PRNewswire/ ... Markets ( http://www.researchandmarkets.com/research/3zh3q8/global_hormone ) has announced the addition ... 2014-2018"  report to their offering.  ... known as hormone therapy, is a means ... being produced by the body. This type ...
(Date:8/21/2014)... 2014 Telomere Biosciences, LLC (Telomere Biosciences) ... for Dogs" with Telomerase Activation Complex , ... world for dogs. Telomeres are the protective caps ... body. A wealth of ground-breaking research by some ... and Aging, including Nobel laureates, has demonstrated a ...
(Date:8/21/2014)...  Decision Resources Group finds that the asthma ... Mexico currently faces severe ... agents, the anticipated label extension of Boehringer Ingelheim/Pfizer,s ... emerging biologics will substantially increase the competitiveness of ... inhibitors will introduce a new dynamic to the severe, ...
Breaking Biology Technology:Scientists observe quantum vortices in cold helium droplets 2Global Hormone Replacement Therapy Market 2014-2018: Key Vendors are Actavis, Bayer, Merck & Co, Novartis and Novo Nordisk 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3
... From toothpaste to technology, noncrystalline or amorphous silica is ... we use in our daily lives. As a minor, ... silica reactivity in physiological environments is crucial to the ... bone-like properties. , One ongoing question is why solutions ...
... July 7 Medarex, Inc.,(Nasdaq: MEDX ) invites ... a live webcast of its 2008 R&D Day event. ... 8:00 a.m. Eastern Time and is expected to,last approximately ... overview of the company,s strategy, progress and new information,about ...
... of the Ferring Research,Infertility and Gynaecology GrAnt (FRIGGA) ... Reproduction & Embryology Congress. The two,winners of this ... The,Netherlands and the Universitair Ziekenhuis (UZ) Brussel, Centre ... selected for their outstanding,proposals for fundamental research to ...
Cached Biology Technology:New insight to demineralization 2Medarex Announces July 10 Live Webcast of R&D Day Event 2Ferring Research Infertility and Gynaecology GrAnt (FRIGGA) 2008 Winners Announced 2Ferring Research Infertility and Gynaecology GrAnt (FRIGGA) 2008 Winners Announced 3
... of Molecular Imaging (MI) Software for use ... research and drug discovery applications. The Regulatory ... and Drug Administrations Code of Federal Regulations ... Signatures [21 CFR Part 11]. KODAK MI ...
... Microarrays designed for pathway studies, ... protein (PTB) Studies built on the ... synthesis platform. These microarrays are available ... Peptide Microarray Service. Custom ...
... one mouse-click image analysis software for ... is the solution for high quality ... MicroVigene is empowered with VigeneTechs robust ... regional 2D-curve fitting background correction and ...
fully automated system for the processing of microarrays on microscope slides...
Biology Products: