Navigation Links
'Pinball protons' created by ultraviolet rays and other causes can lead to DNA damage

Researchers have known for years that damaged DNA can lead to human diseases such as cancer, but how damage occurs--and what causes it--has remained less clear.

Now, computational chemists at the University of Georgia have discovered for the first time that when a proton is knocked off one of the pairs of bases that make up DNA, a chain of damage begins that causes "lesions" in the DNA. These lesions, when replicated in the copying mechanisms of DNA, can lead to serious disorders such as cancer.

The research, just published in the Proceedings of the National Academy of Sciences (PNAS), was led by doctoral student Maria Lind and Henry F. Schaefer III, Graham-Perdue Professor of Chemistry. Other authors on the paper are doctoral student Partha Bera, postdoctoral associate Nancy Richardson and recent doctoral graduate Steven Wheeler.

Call it a "pinball proton." While chemists have shown other causes of DNA damage, the report in PNAS is the first to report how protons, knocked away by such mechanisms as radiation or chemical exposure, can cause lesions in DNA. The work was done entirely on computers in the Center for Computational Chemistry, part of the Franklin College of Arts and Sciences at UGA.

"This kind of damage in DNA subunits is about as basic as you can get," said Schaefer. "This is the simplest kind of lesion possible for such a system."

The double-helix structure of DNA has been known for more than half a century. This basic building block of life can "unzip" itself to create copies, a process at the heart of cell replication and growth. DNA is made of four "bases," Adenine, Guanine, Thymine and Cytosine, and each one pairs with its opposite to form bonds where the "information" of life is stored. Thus, Guanine pairs with Cytosine, and Thymine with Adenine.

The team at the University of Georgia studied how the removal of a proton from the Guanine-Cytosine (G-C) base pair is involved in creating lesions that ca
'"/>

Source:University of Georgia


Page: 1 2

Related biology news :

1. Molecular research suggest shift needed in how some drugs are created
2. All placebos not created alike
3. Polynesia explorers created worldwide web of scientific knowledge
4. Sperm created in the laboratory from embryonic stem cells produce viable progeny
5. Cloned mice created from fully differentiated cells, a milestone in cloning research
6. Researcher examines polymers created with poultry feathers
7. Early-stage sperm cells created from human bone marrow
8. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
9. Another Look Finds Promising Proteomics Test is Not Biologically Plausible
10. Elephants imitate truck noises, other animals
11. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
Post Your Comments:
(Date:7/10/2014)... July 2, 2014 NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication ... Mr. Gino Pereira was interviewed on July 1 ... Tampa Florida . Mr. Pereira discusses the company,s ... Harris and how the Wocket™ aims to replace a ... Cedric Harris tells Gino he has never ...
(Date:7/10/2014)... 7, 2014 Fingerprint Cards, (FPC,s) new ... win (DW). A Chinese Top 5 smartphone OEM has selected ... mass production in October 2014.   FPC is ... smartphone OEM, which has a planned date for the start ... volume for this phone of 3 million units. The Chinese ...
(Date:7/10/2014)... -- Acuity Market Intelligence today released forecasts from "The Global ... global market for National Electronic ID (eID) programs will generate ... time, the number of National eID cards in circulation will ... , with its vast population, will dominate the market ... Europe trails a distant second at ...
Breaking Biology News(10 mins):Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4FPC Wins DW for 1021 Touch Sensor for Flagship Smartphone from Chinese Top 5 Smartphone OEM 2National Electronic ID Programs Generate $54 Billion Between 2013 and 2018 with 3.5 Billion National eID Card Holders Worldwide 2
... against an abnormal protein found in some tumors has the ... and in turn prevent progression to colon cancer, according to ... findings are reported this week in Cancer Prevention Research ... People with chronic inflammatory disorders such as IBD are ...
... the deep ocean floor support abundant populations of organisms, ... oxygen, according to an international study led by scientists ... global warming is likely to exacerbate oxygen depletion and ... The sunlit surface waters tend to be well ...
... Protein phosphorylation is a process by which proteins ... It is a crucial function for most living ... including metabolism, gene transcription, cell-cycle progression, cytoskeletal rearrangement ... in biology, scientists have wanted to learn more ...
Cached Biology News:Vaccine could delay bowel inflammation and colon cancer, says Pitt research 2Seabed biodiversity in oxygen minimum zones 2Seabed biodiversity in oxygen minimum zones 3Key enzyme discovered to be master regulator in protein-protein reactions 2
(Date:7/11/2014)... BCC Research ( http://www.bccresearch.com ) reveals in ... (PCR) TECHNOLOGY: GLOBAL MARKETS , the global market for ... billion in 2013. This is estimated to grow to ... growth rate (CAGR) of 28.6%. , New digital PCR ... possibilities within the broader PCR field. The opportunities presented ...
(Date:7/10/2014)... Women in the West African ... additional family planning option. Sayana® Press has the ... levels of the health system and in communities ... used contraceptive—Pfizer’s Depo-Provera® (depot medroxyprogesterone acetate)—with the BD ... first of four African countries expected to begin ...
(Date:7/10/2014)... 2014 Unraveling life’s mysteries can intrigue, ... Archer Family purchased a DNA test to ... up with a lifetime of memories, sharing, and closeness. ... members’ DNA genuinely brought the family closer together. ... into genetic history and prior to taking the ...
(Date:7/10/2014)... July 10, 2014  Franciscan St. Anthony ... capnography for respiratory monitoring outside the operating ... leaders in embracing state-of-the-art patient safety technology. ... are breathing and can alert medical caregivers ... the amount of carbon dioxide the patient ...
Breaking Biology Technology:Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2
... March 30 BioSpecifics Technologies Corp. (Nasdaq: ... collagenase-based products, today announced its financial results for the ... "We are very happy to report that our partner ... completing enrollment in a Phase IIb trial in Peyronie,s ...
... FORD, Pa., March 30 Endo Pharmaceuticals (Nasdaq: ... J. Hutson, Ph.D., to the company,s board of directors. ... after spending 25 years in various research and leadership ... vice president, Pfizer Global Research and Development and director ...
... Double Helix Consulting US, a division of London-based ... of Ann Stuchiner to the position of Vice ... highly experienced strategic pricing, reimbursement and market access ... which provide product commercialization services to firms in ...
Cached Biology Technology:BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2008 Financial Results 2BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2008 Financial Results 3BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2008 Financial Results 4BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2008 Financial Results 5BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2008 Financial Results 6BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2008 Financial Results 7Endo Pharmaceuticals Appoints Dr. Nancy Hutson to Board of Directors 2Endo Pharmaceuticals Appoints Dr. Nancy Hutson to Board of Directors 3Endo Pharmaceuticals Appoints Dr. Nancy Hutson to Board of Directors 4Double Helix Appoints Ann Stuchiner Vice President of US Consulting Division 2
IMAGEQUANT 100 WKSTN, 1 EA. Category: ImageQuant CCD Imagers....
The FlowTACS Apoptosis Detection Kit is designed specifically for in situdetection of apoptotic...
RayBio Human Cytokine Antibody Array 1.1 (4 array membranes) with Accessory, detects 20 cytokines (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
HybriWell™ hybridization sealing system, 22 mm x 22 mm chamber, 0.15 mm deep *set of 100*...
Biology Products: