Navigation Links
Picking apart how neurons learn

odified mice lacking different proteins required for establishing LTD.

Mice lacking the PICK1 protein are unable to establish LTD or remove AMPA receptors from cell surfaces. When PICK1 is added artificially back into these neurons, AMPA receptors are removed and LTD is restored, showing that PICK1 is necessary for LTD.

Mice lacking the part of the AMPA receptor thought to physically interact with PICK1 also do not establish LTD. This result confirms that PICK1 must physically touch the AMPA receptor for LTD to occur.

The second critical step in establishing LTD involves a chemical change to the AMPA receptor, called phosphorylation. Mice lacking a small part of the AMPA receptor - the part where phosphorylation is thought to occur - do not undergo LTD. This result confirms that phosphorylation is an essential step toward LTD.

With these three different mouse populations in hand, the research team is poised to further dissect the molecular mechanisms behind learning. "The next step is to determine whether LTD is crucial for motor learning, the so-called holy grail in the field," says one of the study's co-first authors, Jordan Steinberg, an M.D., Ph.D. candidate at Hopkins.


'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2

Related biology news :

1. Picking particles faster than one at a time
2. Tiny roundworms telomeres help scientists to tease apart different types of aging
3. First real-time view of developing neurons reveals surprises, say Stanford researchers
4. One gene links newborn neurons with those that die in diseases such as Alzheimers
5. Researchers make surprise discovery that some neurons can transmit three signals at once
6. Speak up: Louder neurons form more connections
7. Eating, body weight regulated by specific neurons
8. New neurons take baby steps in the adult brain
9. Algal protein in worm neurons allows remote control of behavior by light
10. Researchers get neurons and silicon talking
11. Mechanism for memory revealed in neurons of electric fish
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Picking apart how neurons learn

(Date:10/16/2014)... , October 16, 2014 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... edge technologies including Wocket™, the Smart Wallet, at the ... FiRe is a leading global conference on the intersection ... by Mark Anderson , founder and publisher of ...
(Date:10/15/2014)... Johannes Gutenberg University Mainz (JGU) as a full ... to maintain a significant nationwide standing in the ... of Johannes Gutenberg University Mainz as a full ... the national and international competition for the best ... can be proud that Mainz University has been ...
(Date:10/15/2014)... awarded the 44th Rosenstiel Award for Distinguished Work in ... exploring the mechanisms of genomic instability and its implications ... the second alumnus to win the Rosenstiel Award; the ... , Alt is the Charles A. Janeway Professor of ... and an investigator at the Howard Hughes Medical Institute ...
Breaking Biology News(10 mins):NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2
... received an offer to establish its first foreign institute in ... proposed the sum of $86.9 million for the next 10 ... State of Florida will contribute funds to complete the financing, ... will take place. The County,s decision paved the ...
... out that older men chasing younger women contributes ... according to new findings by,researchers at Stanford and ... says that individuals should die of old age ... 55 in humans,according to demographer Cedric Puleston, a ...
... Calif., September 12, 2007 - UC Irvines Henry ... million gift from Edwards Lifesciences Corporation to establish ... next generation of cardiovascular devices. The Edwards ... interaction and collaboration among students, faculty members and ...
Cached Biology News:Palm Beach County wants to establish a Max Planck Institute in Florida 2Men shed light on the mystery of human longevity, study finds 2Men shed light on the mystery of human longevity, study finds 3Men shed light on the mystery of human longevity, study finds 4UCI receives $5M from Edwards Lifesciences 2
(Date:10/22/2014)... SAN DIEGO and HONG KONG ... an innovative rare disease therapeutics enterprise, announced today that ... joined the company as vice president, research. Dr. McKew ... research, including key leadership positions at the National Institutes ... to its acquisition by Wyeth). Dr. McKew will lead aTyr,s ...
(Date:10/20/2014)... 20, 2014 Convey Computer , ... team from Iowa State University won first place in ... a Convey HC-2ex, the team’s solution achieved the highest ... than the second place finisher. , Experts from all ... the month long challenge, using a variety of design ...
(Date:10/20/2014)... , October 20, 2014 ... gastrointestinal (GI) disorders and the delivery of care has ... diseases and worrying inequalities in the provision of healthcare ... which was commissioned by United European Gastroenterology (UEG), have ... political and public awareness of the burden of GI ...
(Date:10/20/2014)... October 20, 2014 OncLive® ... Kimmel Cancer Center at Thomas Jefferson University has ... Through the Strategic Alliance Partnership program, the Sidney ... collaborate to raise awareness of the Center’s cutting-edge ... other projects. Clinicians and other health care professionals ...
Breaking Biology Technology:aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3
... LEIDEN, The Netherlands, and PARSIPPANY, N.J., Feb. 10 ... CRXL ; Swiss Exchange: CRX) announced today that they ... Utrecht, The Netherlands to join their Vendor Network. Under ... pre-approved cell line generation partner for licensees of the ...
... YORK, Feb. 9 5W Public Relations, a Top 25 ... Holtorf, founder of the Holtorf Medical Group and the Yan ... Trokel to its diverse roster of clientele. Both medical centers ... relations programs."We are delighted that Dr. Kent Holtorf and the ...
... Beckman Coulter, Inc. (NYSE: BEC ) ... a quarterly dividend payout of seventeen cents ($0.17) ... March 6, 2009 to all stockholders of record ... the 79th consecutive, quarterly payout of dividends.(Logo: ...
Cached Biology Technology:DSM and Crucell Sign Agreement with Bioceros to Serve as Pre-Approved Cell Line Generation Partner of PER.C6(R) Cell Line Proteins 2DSM and Crucell Sign Agreement with Bioceros to Serve as Pre-Approved Cell Line Generation Partner of PER.C6(R) Cell Line Proteins 3DSM and Crucell Sign Agreement with Bioceros to Serve as Pre-Approved Cell Line Generation Partner of PER.C6(R) Cell Line Proteins 4DSM and Crucell Sign Agreement with Bioceros to Serve as Pre-Approved Cell Line Generation Partner of PER.C6(R) Cell Line Proteins 5The Holtorf Medical Group and Yan Center for Corrective & Cosmetic Surgery Tap 5W Public Relations 2
... The Helios gene gun system, 220-240 V, ... biomaterials into cells. This handheld device employs ... RNA-, and other biomaterial-coated gold microcarriers from ... cartridge directly into target cells. This system ...
Mouse polyclonal antibody raised against a partial recombinant MHC2TA. NCBI Entrez Gene ID = 4261...
... Digital Sight DS-L2 imaging controller is a ... DS-L1, and allows users to comfortably observe, ... DS-L2 controller features an 8.4 inch LCD ... variety of Nikon cameras including the DS-Fi1 ...
Mouse monoclonal antibody to ST8SIA2 - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2...
Biology Products: