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Physical and functional interaction of key cell growth molecules linked to cancer

ies, there has previously been no direct connection made between EGFR and the iNOS/NO pathway.

The researchers conclude that the complex formed by EGFR and STAT3 can directly regulate gene expression and provides a new transcriptional mechanism that may play a significant role in human cancers, transducing cell signals from outside the cell into the nucleus. According to Dr. Hung, "As in OS serves as a direct target of the identified EGFR/STAT3 transcriptional complex, the deregulated iNOS/NO pathway may, in part, contribute to the malignant biology of tumor cells with high levels of nuclear EGFR and STAT3." This research may open new avenues for designing anticancer therapies against EGFR, STAT3, and iNOS/NO.


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Source:Cell Press


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