Navigation Links
Physical and functional interaction of key cell growth molecules linked to cancer

Scientists have uncovered new information about a specific mechanism involved in the biology of malignant human tumor cells. The findings, published in the June issue of Cancer Cell, significantly advance knowledge about epidermal growth factor receptor (EGFR).

EGFR is a well-studied cell surface receptor that stimulates cell growth by transmitting growth factor signals acting outside the cell. EGFR is often present at abnormally elevated levels in human cancer cells. Increased EGFR activity has been linked to metastasis and treatment resistance for aggressive human tumors and, as a result, the EGFR has been identified as an attractive target for cancer therapeutics. However, the precise role of EGFR in cancer cell biology has remained elusive.

Recent studies have shown that in response to growth factor stimulation, a fraction of EGFR molecules move from the cell membrane into the nucleus, where the genetic material of the cell is located. These research studies suggest that EGFR itself probably does not directly regulate gene expression, but may interact with other as yet unidentified molecules in the nucleus. A better understanding of the role of the EGFR signaling pathway in the progression of cancer will be useful for development of new anticancer therapeutics.

In the current study, Dr. Mien-Chie Hung and colleagues from the Department of Molecular and Cellular Oncology at the University of Texas M.D. Anderson Cancer Center found that EGFR interacts with STAT3 in the cell nucleus. STAT3 is a molecule that is known to bind to DNA and directly regulate gene expression. STAT3 has also been shown to have a major role in oncogenesis. Importantly, interaction with STAT3 provides a mechanism for EGFR-driven regulation of gene transcription. The researchers also discovered that the EGFR/STAT3 interaction leads increased expression of inducible nitric oxide synthase (iNOS). Although elevated iNOS is also a key characteristic of many human malignanc
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Towards precise classification of cancers based on robust gene functional expression profiles
2. Bone marrow cells can become functional gut lining cells
3. Virus-host interactions at sea effect global photosynthesis
4. Future diabetes drugs may target new protein interaction
5. Computational verification of protein-protein interactions by orthologous co-expression
6. Confirmation of human protein interaction data by human expression data
7. Complex gene interactions account for autism risk
8. Image of myosin-actin interaction revealed in cover story of Molecular Cell
9. A real time look at interactions between RNA and proteins
10. U of MN researchers develop way to visualize synchronized interactions of nerve cells in the brain
11. Biologists visualize protein interaction that may initiate viral infection
Post Your Comments:
(Date:9/15/2014)... animalsto thrive in the oceans, there must be ... coastal areas, extreme oxygen-starvation produces "dead zones" that ... As dissolved oxygen levels decline, energy is increasingly ... metabolism resulting in impacts on the ecology and ... 50 years, oxygen minimum zones (OMZs) have expanded ...
(Date:9/15/2014)... scientists from GEOMAR Helmholtz Centre for Ocean Research ... have demonstrated for the first time, that the ... oceans, Emiliania huxleyi , can adapt simultaneously ... their study, the researchers found no evidence for ... two aspects of climate change would interfere with ...
(Date:9/15/2014)... 100 feet long and weighing as much as 170 tons, ... and by far the heaviest living thing ever seen on ... common with the tiniest fish larvae, which measure millimeters in ... gram, right? , Not so fast, says L. Mahadevan, ... Organismic and Evolutionary Biology, and of Physics. , Using ...
Breaking Biology News(10 mins):Decoding virus-host interactions in the oxygen-starved ocean 2Decoding virus-host interactions in the oxygen-starved ocean 3Decoding virus-host interactions in the oxygen-starved ocean 4Decoding virus-host interactions in the oxygen-starved ocean 5Small algae with great potential 2Small algae with great potential 3The science behind swimming 2The science behind swimming 3
... often simply called lupus, is a complex autoimmune ... fatigue, and depression, among other symptoms. Some studies ... severe psychiatric manifestation, psychosis, and a protein autoantibody ... , To investigate how an autoantibody ...
... continue to debate how different species manage to ... as food, invariably one will be more efficient ... that each species has evolved morphological or physiological ... more efficiently than all other species. Such partitioning ...
... Genetics tests could help provide cystic fibrosis (CF) ... authors suggest. Results from a French clinical trial ... small percentage of CF sufferers with a rare ... , Aleksander Edelman and Isabelle Sermet-Gaudelus of Faculté ...
Cached Biology News:New insights into autoimmunity and depression 2Virtual duck bills demonstrate species coexistence 2
(Date:9/12/2014)... Arthur Kay , the 23-year-old British founder of environmentally ... Challenge 2014. The jury, chaired by Ellen MacArthur ... final in Amsterdam to realize ... uses a patented process to upcycle waste coffee grounds ... used for powering buildings and transport systems. Bio-bean is ...
(Date:9/12/2014)... September 12, 2014 Today, “The University” ... Indiegogo. , The film, directed by former Charlie ... Shimon Peres, Ashton Kutcher, Will.i.Am, Michio Kaku, and others. ... there’s only one university in the world devoted to ... the lives of a billion people: Singularity University. Matt ...
(Date:9/11/2014)... 12, 2014 RURO, Inc., a ... (RFID) solutions and sample management solutions provider, announces ... completed work on the most recent version of ... has already seen mass adoption, especially from multi-license ... version 5.0 brought an entirely new User Interface ...
(Date:9/11/2014)... to show the use of sound to communicate with ... quantum physics with sound taking on the role of ... Science . , The interaction between atoms and ... in the field of quantum optics. However, to achieve ... been a more challenging undertaking. The Chalmers researchers have ...
Breaking Biology Technology:Green Startup Bio-Bean Wins $680,000 in Postcode Lottery Green Challenge 2Green Startup Bio-Bean Wins $680,000 in Postcode Lottery Green Challenge 3Documentary Film that Follows Singularity University Students as They Change the World Launches its IndieGoGo Fundraising Campaign 2Limfinity® Version 5.1 Available 2The sound of an atom has been captured 2
... High Quality Digital Imaging Solution Now Available in ... Medical Systems, a leading supplier of digital radiography ... and practice management software (VIA(R)), will showcase its ... RapidStudy(TM) DR imaging solutions at the annual Central ...
... April 22 GeneGo, Inc., a leading provider of ... analysis , today announced that the University of Cardiff ... University researchers will have access to GeneGo,s MetaCore, training ... leverage their partner relationship with GeneGo to provide a ...
... The PharmSource ADVANTAGE online service has added two new capabilities ... providers. , ... Fairfax, Virginia (PRWEB) ... provider of business intelligence on contract drug development and manufacture, ...
Cached Biology Technology:Eklin Medical Systems to Showcase RapidStudy(TM) CDx Digital Radiography Systems at CVC East 2Eklin Medical Systems to Showcase RapidStudy(TM) CDx Digital Radiography Systems at CVC East 3Cardiff University Becomes a GeneGo Center of Excellence 2PharmSource Adds New Capabilities to the PharmSource ADVANTAGE Online Service 2
... that enables fully automated hybridization of microarrays ... has been designed to offer researchers improved ... to perform a wide range of applications. ... range 485C; denaturations of up to 99C. ...
... cDNA Synthesis and Labeling Kit generates labeled ... First unmodified cDNA is made via a ... an Oligo(dT) primer. Unlike other methods, there ... the reverse transcription reaction. This unmodified cDNA ...
... Kits overcome this limitation and offer high ... range in low-density protein array (96- and ... ideal for performing reverse-phase protein arrays and ... presence of low abundant antigens. Protein Detector ...
AC input: 50-60 Hz230 V...
Biology Products: