Navigation Links
Physical and functional interaction of key cell growth molecules linked to cancer

Scientists have uncovered new information about a specific mechanism involved in the biology of malignant human tumor cells. The findings, published in the June issue of Cancer Cell, significantly advance knowledge about epidermal growth factor receptor (EGFR).

EGFR is a well-studied cell surface receptor that stimulates cell growth by transmitting growth factor signals acting outside the cell. EGFR is often present at abnormally elevated levels in human cancer cells. Increased EGFR activity has been linked to metastasis and treatment resistance for aggressive human tumors and, as a result, the EGFR has been identified as an attractive target for cancer therapeutics. However, the precise role of EGFR in cancer cell biology has remained elusive.

Recent studies have shown that in response to growth factor stimulation, a fraction of EGFR molecules move from the cell membrane into the nucleus, where the genetic material of the cell is located. These research studies suggest that EGFR itself probably does not directly regulate gene expression, but may interact with other as yet unidentified molecules in the nucleus. A better understanding of the role of the EGFR signaling pathway in the progression of cancer will be useful for development of new anticancer therapeutics.

In the current study, Dr. Mien-Chie Hung and colleagues from the Department of Molecular and Cellular Oncology at the University of Texas M.D. Anderson Cancer Center found that EGFR interacts with STAT3 in the cell nucleus. STAT3 is a molecule that is known to bind to DNA and directly regulate gene expression. STAT3 has also been shown to have a major role in oncogenesis. Importantly, interaction with STAT3 provides a mechanism for EGFR-driven regulation of gene transcription. The researchers also discovered that the EGFR/STAT3 interaction leads increased expression of inducible nitric oxide synthase (iNOS). Although elevated iNOS is also a key characteristic of many human malignanc
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Towards precise classification of cancers based on robust gene functional expression profiles
2. Bone marrow cells can become functional gut lining cells
3. Virus-host interactions at sea effect global photosynthesis
4. Future diabetes drugs may target new protein interaction
5. Computational verification of protein-protein interactions by orthologous co-expression
6. Confirmation of human protein interaction data by human expression data
7. Complex gene interactions account for autism risk
8. Image of myosin-actin interaction revealed in cover story of Molecular Cell
9. A real time look at interactions between RNA and proteins
10. U of MN researchers develop way to visualize synchronized interactions of nerve cells in the brain
11. Biologists visualize protein interaction that may initiate viral infection
Post Your Comments:
(Date:8/20/2014)... 158 pregnant teenagers in Rochester, NY, nearly half engaged ... ice, cornstarch, vacuum dust, baby powder and soap, and ... Moreover, such teens had significantly lower iron levels as ... , Pregnant teens, regardless of pica, are at higher ... deficiency and anemia. Low iron in pregnant teens raises ...
(Date:8/20/2014)... in this image of the Para and Mato Grosso ... likely intentionally set in order to deforest the land. ... of trees where the land is thereafter converted to ... forestland to farms, ranches, or urban use. The herringbone-patterned ... Amazon Rainforest in the middle of the image are ...
(Date:8/20/2014)... have suffered concussions ready to return to action? A ... school athletes who head back on the field with ... in their abilities to simultaneously walk and do simple ... in their balance and/or altered walking speed, was found ... had returned to activity in less than a month. ...
Breaking Biology News(10 mins):Pica in pregnant teens linked to low iron 2Recovery reversal seen in Oregon study of returning concussed athletes 2Recovery reversal seen in Oregon study of returning concussed athletes 3
... international group of scientists is linking nutrient pollution in the ... harmful algal blooms reported in recent years. When harmful algal ... respiratory and skin irritations and cause fish or mammal kills ... the journal Harmful Algae , scientists present a compilation ...
... of the Journal of the American Dietetic Association ... Researchers look at why sack lunches may not always meet ... for meals directly influences diets of young adults. ... Idea , Approximately 13 million children in the United ...
... Amsterdam, January 6, 2009 Elsevier, a leading global ... finalists chosen in the Elsevier Grand Challenge, a ... the ever-increasing amount of online life sciences information. ... was held on December 15th at the Massachusetts ...
Cached Biology News:News from the January 2009 Journal of the American Dietetic Association 2Finalists announced in the Elsevier Grand Challenge 2Finalists announced in the Elsevier Grand Challenge 3
(Date:8/20/2014)... Livermore, California (PRWEB) August 20, 2014 ... to develop and apply the most complete climate ... challenging and demanding climate change issues. , Eight ... combining forces with the National Center for Atmospheric ... in the new effort. Other participating national laboratories ...
(Date:8/20/2014)... SAN JOSE, Calif. , Aug. 20, 2014 ... UCSD highlights the transformative collaboration between the school,s ... (IoT).  As part of the Intel® Software Academic ... between computer sciences and the human body.  ... The study exhibits the work of ...
(Date:8/19/2014)... 19, 2014 Shimadzu Scientific Instruments ... Prominence-i and Nexera-i, adding to the company’s extensive ... functionality, an intuitive operating environment, and full automation, ... efficient workflow for conventional to ultra-high-speed analysis. ... and intelligent design so users can begin building ...
(Date:8/19/2014)... Robin Williams’ passing is a sad reminder ... individual. Symptoms range from slowness of voluntary movements ... severe depression. Parkinson’s disease progressively gets worse over ... neurons of the brain. As these patients struggle ... progressively gets worse, they look for options. ...
Breaking Biology Technology:New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 2As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 3
... Today we begin three weeks of special articles, ... Wisconsin Technology Network (WTN). This series called, "FORWARD ... debate that will help to illustrate some of ... Science and Technology Recognition Week, November 1-7. WTN ...
... itself to the information age similar to what the ... increase the productivity of our staff, reduce costs, and ... is a considerable engineering effort that requires hospital officials ... how they can embrace the changes that will improve ...
... want to evolve their technology expenditures from mere business expenses ... period of time. As legacy systems reach the end of ... a prioritized technology vision that addresses both business and employee ... convergence of voice and data to a single network is ...
Cached Biology Technology:Why Wisconsin Lags Behind the U.S. and Minnesota 2Why Wisconsin Lags Behind the U.S. and Minnesota 3Why Wisconsin Lags Behind the U.S. and Minnesota 4Why Wisconsin Lags Behind the U.S. and Minnesota 5Im Still Waiting for the Information Age in Healthcare 2Im Still Waiting for the Information Age in Healthcare 3Technology Investment in the Next 24 Months 2Technology Investment in the Next 24 Months 3
Rabbit Anti-Human Janus Kinase 2 (JAK2 Polyclonal Antibody Family: Protein Kinase Sub-Family: TYK2/JAK Applications: ELISA, Western Blot...
MAb to HSV-2, gG-2 HSV-2 Glycoprotein G-2...
Immunogen for A300-655A was a phosphorylated synthetic peptide, which represented a portion of human RNA Polymerase II (GeneID 5430) around serine 5 of the C-terminal repeat YSPTSPS....
human Exodus-2 Research Focus: cytokine/growth factor Storage Temperature: -20C Shipping Temperature: 4C...
Biology Products: