Navigation Links
Phthalates now linked to fat, related health risks

Exposure to phthalates, a common chemical found in everything from plastics to soaps, already has been connected to reproductive problems and now, for the first time, is linked to abdominal obesity and insulin resistance in adult males, according to a study by the University of Rochester Medical Center.

The research adds to the growing suspicion that low-dose exposures to phthalates and other common chemicals may be reducing testosterone levels or function in men, and thereby contributing to rising obesity rates and an epidemic of related disorders, such as Type 2 diabetes, said lead author Richard Stahlhut, M.D., M.P.H., a Preventive Medicine resident at the University of Rochester. The study was published today in the online edition of the journal Environmental Health Perspectives.

"Substantial declines in testosterone levels and sperm quality have been observed in the United States and other countries over the last several decades which and it urgently requires explanation," Stahlhut said. "While we can’t say yet that phthalates are a definite cause, I am certain they are on the list of chemicals that demands careful study."

Phthalates have been widely used for more than 50 years, but only recently implicated as a possible health risk in people. Animal studies have shown consistently that phthalates depress testosterone levels. Recent human studies have found that phthalates are associated with poor semen quality in men and subtle changes in the reproductive organs in boy babies. This connection between phthalates and testosterone helped to establish a basis for the study, Stahlhut said.

Stahlhut’s group hypothesized that phthalates might have a direct link to obesity, since low testosterone appears to cause increased belly fat and pre-diabetes in men. They analyzed urine, blood samples and other data from the National Health and Nutrition Examination Survey. The NHANES is a large, multi-ethnic, cross-section sampling of the U.S. population acquired routinely by the Centers for Disease Control and Prevention. Researchers reviewed data from 1999 to 2002, the most recent years that phthalates levels were available. Of the adult men available in NHANES, 1,451 had data on phthalate exposures, obesity and waist circumference. Of these men, 651 also had fasting glucose and insulin levels required to calculate insulin resistance.

The analysis found that, as expected, several phthalate metabolites showed a positive correlation with abdominal obesity. Indeed, men with the highest levels of phthalates in their urine had more belly fat and insulin resistance. Researchers adjusted for other factors that could influence the results, such as the mens?age, race, food intake, physical activity levels and smoking.

The phthalate family of chemicals is used in a variety of products from cosmetics, shampoos, soaps, lotions, lubricants, paint, pesticides, and plastics. Phthalates soften plastic tubing, PVC, and are also used in the coating of some timed-release medicines.

More than 75 percent of the United States population has measurable levels of several phthalates in their urine, according to the study.

"Unfortunately, there’s still a lot to learn about phthalates," Stahlhut said. "The more difficult issue is what combinations of common low-dose chemical exposures might be contributing to these problems."
'"/>

Source:University of Rochester Medical Center


Related biology news :

1. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
2. Low level of extinction during ice age linked to adaptability
3. Improved statistical tools reveal many linked loci
4. Scientists at Galileo Pharmaceuticals confirm inflammatory response linked to glucose levels
5. Attacks of King George IIIs madness linked to key metabolism molecule
6. Gene controlling circadian rhythms linked to drug addiction
7. Physical and functional interaction of key cell growth molecules linked to cancer
8. VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells
9. Naturally occurring asbestos linked to lung cancer
10. Disappearing arctic lakes linked to climate change
11. Genes linked to treatment resistance in children with leukemia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... The research team of The Hong Kong Polytechnic University ... adopting ground breaking 3D fingerprint minutiae recovery and matching technology, pushing ... for use in identification, crime investigation, immigration control, security of access ... ... A research team led by Dr Ajay ...
(Date:3/29/2017)... , March 29, 2017  higi, the health IT ... North America , today announced a ... the acquisition of EveryMove. The new investment and acquisition ... of tools to transform population health activities through the ... data. higi collects and secures data today ...
(Date:3/27/2017)... , March 27, 2017  Catholic Health Services ... Management Systems Society (HIMSS) Analytics for achieving Stage ... Model sm . In addition, CHS previously earned ... hospitals using an electronic medical record (EMR). ... high level of EMR usage in an outpatient ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and ... San Diego Rotary Club. The event entitled “Stem Cells and Their ... 300+ attendees. Dr. Harman, DVM, MPVM was joined by two human doctors: Peter ...
(Date:10/10/2017)... CRUZ, Calif. , Oct. 10, 2017 ... grant from the NIH to develop RealSeq®-SC (Single Cell), ... kit for profiling small RNAs (including microRNAs) from single ... Analysis Program highlights the need to accelerate development of ... "New techniques for measuring ...
(Date:10/10/2017)... ... 2017 , ... The Pittcon Program Committee is pleased to ... who have made outstanding contributions to analytical chemistry and applied spectroscopy. Each award ... conference and exposition for laboratory science, which will be held February 26-March 1, ...
(Date:10/9/2017)... ... 09, 2017 , ... The award-winning American Farmer television series will feature 3 ... airs Tuesdays at 8:30aET on RFD-TV. , With global population estimates nearing ten ... to continue to feed a growing nation. At the same time, many of our ...
Breaking Biology Technology: