Navigation Links
Phenotype is influenced by nature, nurture and noise

Unscripted biochemical variations, or noise, leads to oscillations in gene regulation that couldn't otherwise be predicted

Geneticists have debated for decades the relative importance of nature versus nurture in determining how an animal looks and behaves, and now UCSD scientists report that noise could also be an important factor in determining phenotype.

In a paper in Proceedings of the National Academy of Sciences released online Sept. 30, the scientists led by bioengineering professor Jeff Hasty reported that a newly developed computer model shows that a combination of unscripted biochemical variations, or noise, leads to oscillations in gene regulation that couldn't otherwise be predicted. Such noise is routinely described by cell biologists who record large phenotypic differences between supposedly identical cells in a single flask of growth medium.

The mental picture most biologists have of a cell is of a smoothly running Swiss watch," said Hasty. "But our results and the findings of other theorists and computational biologists are proving otherwise. The fine-grain fluctuations we see in the genetic regulation within single cells may lead to new insights about variability at the level of a fly, cat, or human."

Changes in a cell's phenotype may be triggered by environmental factors, by programmed genetic instructions, or more subtly by built-in delays in biochemical pathways that generate oscillations, sometimes in 24-hour circadian periods. Hasty, graduate students Dmitri Bratsun and Dmitri Volfson, and post-doctoral fellow Lev. S. Tsimring modified the Gillespie algorithm, a well known computer model of cellular reactions, by factoring in intrinsic noise and delays. Using the modified Gillespie algorithm and sophisticated mathematical analyses of sets of biochemical reactions, the team discovered how the combination of intrinsic noise and biochemical delays also generates oscillations in phenotype.

"We think an analysi s of such fine details of gene regulation explains not only the observed variability of cells, but also, in a larger sense, why identical twins don't necessarily have identical fingerprints," said Hasty. "Given that every potential feature of an organism is ultimately determined at the genetic level, it is important to zoon in on the noisy details of gene expression to explain the variability that we couldn't otherwise account for."


'"/>

Source:University of California - San Diego


Related biology news :

1. Childrens taste sensitivity and food choices influenced by taste gene
2. Toasty oat aroma influenced by presence of health-linked polyphenols
3. Executive monkeys influenced by other executives, not subordinates
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2016)... 2, 2016  BioMEMS devices deployed in ... on medical screening and diagnostic applications, such ... devices that facilitate and assure continuous monitoring ... are being bolstered through new opportunities offered ... acquisition coupled with wireless connectivity and low ...
(Date:2/2/2016)... Feb. 2, 2016  Based on its recent ... Sullivan recognizes US-based Intelligent Retinal Imaging Systems (IRIS) ... Award for New Product Innovation. IRIS, a prominent ... North America , is poised to set ... diabetic retinopathy market. The IRIS technology presents superior ...
(Date:1/27/2016)... Jan. 27, 2016  Rite Track, Inc. a leading ... West Chester, Ohio announced today the ... staff, based in Austin, Texas , ... to provide modifications, installations and technical support offerings for ... of PLUS, commented, "PLUS has provided world class service ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... ... February 09, 2016 , ... Clinovo , the cloud-based ... Electronic Data Capture (EDC) system ClinCaptureand its new Contract Research Organization (CRO) Partner ... Conference in San Mateo, California on February 10th and 11th. Watch 2-min ...
(Date:2/9/2016)... 9, 2016  DNAtrix, a clinical stage, ... announced that its lead product, DNX-2401, has ... an orphan medicinal product for the treatment ... glioma, strikes approximately 25,000 people a year ... http://photos.prnewswire.com/prnh/20160208/330986LOGO --> http://photos.prnewswire.com/prnh/20160208/330986LOGO ...
(Date:2/9/2016)... 9, 2016 DelveInsight,s, ... report provides in depth insights on the ... the Protein-Tyrosine Phosphatase 1B (PTP1B) Inhibitors. The ... various stages of development including Discovery, Pre-clinical, ... and Preregistration. Report covers the product clinical ...
(Date:2/8/2016)... 8, 2016 Novan, Inc. today announced that Director ... of Directors of Novan. In addition, Robert Keegan has ... North Carolina . --> North Carolina ... it received a total of $32.8 million of net proceeds in ... investor network originating throughout the Research Triangle area of ...
Breaking Biology Technology: