Navigation Links
Phenotype is influenced by nature, nurture and noise

Unscripted biochemical variations, or noise, leads to oscillations in gene regulation that couldn't otherwise be predicted

Geneticists have debated for decades the relative importance of nature versus nurture in determining how an animal looks and behaves, and now UCSD scientists report that noise could also be an important factor in determining phenotype.

In a paper in Proceedings of the National Academy of Sciences released online Sept. 30, the scientists led by bioengineering professor Jeff Hasty reported that a newly developed computer model shows that a combination of unscripted biochemical variations, or noise, leads to oscillations in gene regulation that couldn't otherwise be predicted. Such noise is routinely described by cell biologists who record large phenotypic differences between supposedly identical cells in a single flask of growth medium.

The mental picture most biologists have of a cell is of a smoothly running Swiss watch," said Hasty. "But our results and the findings of other theorists and computational biologists are proving otherwise. The fine-grain fluctuations we see in the genetic regulation within single cells may lead to new insights about variability at the level of a fly, cat, or human."

Changes in a cell's phenotype may be triggered by environmental factors, by programmed genetic instructions, or more subtly by built-in delays in biochemical pathways that generate oscillations, sometimes in 24-hour circadian periods. Hasty, graduate students Dmitri Bratsun and Dmitri Volfson, and post-doctoral fellow Lev. S. Tsimring modified the Gillespie algorithm, a well known computer model of cellular reactions, by factoring in intrinsic noise and delays. Using the modified Gillespie algorithm and sophisticated mathematical analyses of sets of biochemical reactions, the team discovered how the combination of intrinsic noise and biochemical delays also generates oscillations in phenotype.

"We think an analysi
'"/>

Source:University of California - San Diego


Page: 1 2

Related biology news :

1. Childrens taste sensitivity and food choices influenced by taste gene
2. Toasty oat aroma influenced by presence of health-linked polyphenols
3. Executive monkeys influenced by other executives, not subordinates
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Phenotype influenced nature nurture and noise

(Date:2/5/2015)... PARK, North Carolina , 5. Februar ... 35. Jahr als spezialisiertes Logistikunternehmen und hat ... als einzige klinische Logistikfirma (Clinical Logistics Organization ... Kernbotschaft der neuen Kampagne lautet First ... Lieferungen. Foto: http://photos.prnewswire.com/prnh/20150205/173753 ...
(Date:2/5/2015)... Jan. 26, 2015   Epic Sciences , a precision ... announced that Murali Prahalad , Ph.D., president and CEO, ... Conference (PMWC) 2015: Silicon Valley, which is taking place ... Calif. on January 26-28, 2015. ... Age as Biomarkers." Last year, Epic Sciences was a finalist ...
(Date:2/5/2015)... IRVINE, Calif. , Jan. 27, 2015 ... trusted provider of globally deployed, innovative test ... today announced the delivery of its ... Martin Space Systems Company (LMSSC). GENASYS is ... the demands of mission-critical applications that require ...
Breaking Biology News(10 mins):Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3Epic Sciences to Present at Personalized Medicine World Conference 2015 on the Use of Circulating Tumor Cells as Cancer Biomarkers 2Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 2Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 3Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 4
... Johns Hopkins scientists have discovered internal "shipping labels" that allow ... proteins to get to the surface of cells and stay ... are the ion channel that lets heart cells contract on ... that causes AIDS, into cells, the researchers discovered. , Because ...
... fierce dinosaur T. rex and a modern songbird such ... systems may have been more similar than scientists previously ... Harvard University. , Though some scientists have proposed that ... reptiles, a new study published in this week's issue ...
... Asia of primate-to-human transmission of simian foamy virus (SFV), a ... has not been shown to cause disease in humans. The ... took place at a monkey temple in Bali, Indonesia, the ... Infectious Diseases. Even though this particular virus jumping to humans ...
Cached Biology News:Hopkins scientists uncover 'tags' that force proteins to cell surface 2Hopkins scientists uncover 'tags' that force proteins to cell surface 3Hopkins scientists uncover 'tags' that force proteins to cell surface 4Study: Predatory dinosaurs had bird-like pulmonary system 2Study: Predatory dinosaurs had bird-like pulmonary system 3Primate virus jumps species barrier to humans for first time in Asia 2Primate virus jumps species barrier to humans for first time in Asia 3
(Date:2/27/2015)... 27, 2015 Research and Markets ( http://www.researchandmarkets.com/research/p2ddnr/global_market ... Report of Trypsin" report to their offering. , ... at providing comprehensive data on Trypsin globally and regionally ( ... North America , Latin America ... to Trypsin This report focuses on three primary ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 FamilyFarms Group ... General Manager of State Line Farms, received the 2015 ... a producer, under the age of 35, who has ... is an honor to win the Tomorrow's Top Producer ... who won the Top Producer Award and learning from ...
(Date:2/26/2015)... 26, 2015 On behalf of biotech client ... Wilentz, Goldman & Spitzer, P.A. (Wilentz) secured a ... Genewiz Inc. in excess of $10 million. The jury ... secrets, and that it improperly hired one or more ... motions for judgment notwithstanding the verdict, a new trial, ...
(Date:2/26/2015)... 26, 2015 Protiviti ( www.protiviti.com ), a ... the Governance Portal , designed to increase the ... (GRC) tasks across multiple business units and projects. The ... customers better align their controls with the COSO ( ... requirements. In response to client feedback, Protiviti has also ...
Breaking Biology Technology:Global Market Report of Trypsin 2014-2018 2Matt Sims Receives the 2015 Tomorrow’s Top Producer Horizon Award 2Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 2Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 3Protiviti Governance Portal Helps Companies Drive Governance, Risk and Compliance Productivity Across Multiple Business Units 2Protiviti Governance Portal Helps Companies Drive Governance, Risk and Compliance Productivity Across Multiple Business Units 3
... Inc. (Nasdaq: RDEA ) today announced that ... study of BAY 86-9766 in advanced cancer patients will ... 2011 American Society of Clinical Oncology (ASCO) Annual Meeting ... Presentation details are as follows:Presentation Title: , ...
... VRML ), a molecular diagnostics company, today announced ...  Mr. Huebner currently serves as Managing Director at LynxCom Partners, ... Huebner has over 35 years of experience in the diagnostic ... in a number of clinical diagnostic companies including Hybritech, Inc., ...
... NEW YORK, May 19, 2011 Reportlinker.com ... is available in its catalogue: ... http://www.reportlinker.com/p0459203/Global-Biosimilars-Industry.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Biopharmaceutical This report ... US$ Million. The report provides separate comprehensive ...
Cached Biology Technology:Ardea Biosciences Announces Data on MEK Inhibitor BAY 86-9766 (RDEA119) to be Presented at 2011 American Society of Clinical Oncology Annual Meeting 2Ardea Biosciences Announces Data on MEK Inhibitor BAY 86-9766 (RDEA119) to be Presented at 2011 American Society of Clinical Oncology Annual Meeting 3Vermillion Announces the Appointment of Bruce Huebner to its Board of Directors 2Vermillion Announces the Appointment of Bruce Huebner to its Board of Directors 3Vermillion Announces the Appointment of Bruce Huebner to its Board of Directors 4Global Biosimilars Industry 2Global Biosimilars Industry 3Global Biosimilars Industry 4Global Biosimilars Industry 5Global Biosimilars Industry 6Global Biosimilars Industry 7Global Biosimilars Industry 8Global Biosimilars Industry 9Global Biosimilars Industry 10
Mouse Serpin F1/PEDF MAb (Clone 199315)...
Immunogen: Full length M32 fusion protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Prostaglandin E2 Luminex Standard Product Lines: Unspecified...
Eppendorf tube holder, for Tube rack 175 x 12 mm, 100. Category: Chromatography Systems & Accessories, Systems....
Biology Products: