Navigation Links
Pest control research leads to pain control discovery

A newly discovered enzyme inhibitor, identified by researchers originally looking for biological pest controls, may lead to pain relief for sufferers of arthritis and other inflammatory diseases, say researchers at the University of California, Davis. The finding, hailed by a noted inflammatory disease expert "as the most important discovery in inflammation in more than a decade," may also reduce side effects associated with the painkiller, Vioxx.

Lead author Kara Schmelzer, a post-doctoral researcher in principal investigator Bruce Hammock's lab, tested the novel compounds on rodents and found them to be as potent at a low-dose as Vioxx and Celebrex, but without the changes in blood chemistry linked to heart attacks. Vioxx and Celebrex belong to a class of drugs known as Cox-2 inhibitors. The enzyme targeted by the newly discovered inhibitors is also found in humans. (Enzymes are proteins that speed up chemical reactions.)

"The reason this is so exciting is that this is a novel way to reduce inflammation, with a combination therapy," Schmelzer said. "We're going after a new enzyme target, not going after the Cox-2 inhibitors."

Their research is reported in a paper entitled "Enhancement of Antinociception by Coadministration of Nonsteroidal Anti-Inflammatory Drugs and Soluble Epoxide Hydrolase Inhibitors," published in the current edition of Proceedings of the National Academy of Sciences.

"Our laboratory was initially interested in regulating the development of insect larvae," said Hammock, a distinguished professor of entomology and member of the National Academy of Sciences. The discovery switched the focus of the research from "pest control to pain control."

M. Eric Gershwin, chief of the Division of Rheumatology, Allergy and Clinical Immunology at the UC Davis School of Medicine and a distinguished professor of medicine, called the discovery "the most important discovery in inflammation in more than a decade." Gershwi
'"/>

Source:University of California - Davis


Page: 1 2 3

Related biology news :

1. Ancient olfaction protein is shared by many bugs, offering new pest control target
2. Gene variations explain drug dose required to control seizures
3. U-M scientists find genes that control growth of common skin cancer
4. Scientists discuss improved biopesticides for locust control in West Africa
5. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
6. To control germs, scientists deploy tiny agents provocateurs
7. Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression
8. Master gene controls healing of skin in fruit flies and mammals
9. Remote control flies? Fly behavior controlled by laser light
10. Internet viruses help ecologists control invasive species
11. DNA constraints control structure of attached macromolecules
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Pest control research leads pain control discovery

(Date:5/18/2015)... Sweden , May 18, 2015 ... fingerprint sensors FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one ... from June until and including Q3 2015 and the sensors ... . Communicated order values for 2015 hereby amount to ... for Q1 2015 of 140 MSEK and a number of ...
(Date:5/14/2015)... 2015  Verificient Technologies, Inc., a technology ... remote proctoring, announced a new alliance partnership ... creator of the Canvas Learning Management System ... will benefit from the seamless integration of ... a fully integrated multifactor biometrics behavioral application, ...
(Date:5/11/2015)... Ohio , May 11, 2015  Through a well-rounded ... Ohio had a strong showing at AUVSI,s Unmanned ... These representatives of Ohio,s UAS industry ... and abroad from all points along the UAS ecosystem. ... Development Coalition,s (DDC) Vice President for Aerospace Rich Knoll ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2
... Boulder, Colo., USA New GSA Bulletin articles cover wind ... on Kauai; new insights from the Petrified Forest, USA; a ... a new model for the development of Ries Crater Lake, ... large earthquakes in northern Fiordland, New Zealand; and the evolution ...
... research at the Institute of Food Research, has taken ... and drug companies worldwide. , IFR and the technology ... from the Biotechnology and Biological Sciences Research Council (BBSRC) ... and improve how well it simulates the release of ...
... surrounds the DNA of our cells could help develop treatments ... have discovered that the proteins within this coating known ... different organs of the body. This variation ... proteins in the protective seal to cause illness in some ...
Cached Biology News:Kauai, the Petrified Forest, Costa Rica, and more: New GSA Bulletin articles now online 2Kauai, the Petrified Forest, Costa Rica, and more: New GSA Bulletin articles now online 3Kauai, the Petrified Forest, Costa Rica, and more: New GSA Bulletin articles now online 4Kauai, the Petrified Forest, Costa Rica, and more: New GSA Bulletin articles now online 5Kauai, the Petrified Forest, Costa Rica, and more: New GSA Bulletin articles now online 6Kauai, the Petrified Forest, Costa Rica, and more: New GSA Bulletin articles now online 7Kauai, the Petrified Forest, Costa Rica, and more: New GSA Bulletin articles now online 8Kauai, the Petrified Forest, Costa Rica, and more: New GSA Bulletin articles now online 9Commercial future for Model Gut 2Cell discovery could hold key to causes of inherited diseases 2
(Date:6/2/2015)... NEWTOWN, Pa. , June 2, 2015   ... services and technology provider, today announced that David ... has been named Executive Vice President and Chief Financial ... 8, 2015. Peters brings more than 25 ... in pharmaceutical services. "David has extensive and deep knowledge ...
(Date:6/2/2015)... , June 2, 2015  Alere Inc. ... rapid diagnostics, joined the White House Antibiotic Stewardship ... commitments to support and advance the President,s National ... commitments include a number of measurable goals and ... achieved, will help healthcare providers protect their patients ...
(Date:6/2/2015)... New Orleans, LA (PRWEB) June 02, 2015 ... of custom gene synthesis to improve protein expression, announced ... The board includes six executives and entrepreneurs with a ... and software industries. , The team includes: , ... Startup Fund: , Roussel has a background in technology ...
(Date:6/1/2015)... and RARITAN, N.J. , June ... (Janssen) announced data from the Phase 3 multicenter ... progression-free survival (PFS) with trabectedin (YONDELIS ® ) ... (LPS) or leiomyosarcoma (LMS) previously treated with an ... SAR3007 is the largest randomized Phase 3 study ...
Breaking Biology Technology:BioClinica Names David Peters New Chief Financial Officer 2Alere Announces Broad Initiatives to Help Combat Antibiotic Resistance during White House Antibiotic Stewardship Forum 2GenoCAD Announces New Board of Advisors, Improves Protein Expression Using Custom Gene Synthesis 2GenoCAD Announces New Board of Advisors, Improves Protein Expression Using Custom Gene Synthesis 3Trabectedin Improves Disease Control in Patients with Advanced Soft Tissue Sarcoma 2Trabectedin Improves Disease Control in Patients with Advanced Soft Tissue Sarcoma 3Trabectedin Improves Disease Control in Patients with Advanced Soft Tissue Sarcoma 4Trabectedin Improves Disease Control in Patients with Advanced Soft Tissue Sarcoma 5Trabectedin Improves Disease Control in Patients with Advanced Soft Tissue Sarcoma 6
... BIOD ) today reported financial results for the ... Quarter Operating Highlights During Biodel,s third quarter of ... 1 testing of two new ultra-rapid-acting formulations of recombinant human ... at Oregon Health and Sciences University who have initiated a ...
... Calif. and TORONTO, Aug. 4, 2011 ... developing a first-in-class anti-apoptosis therapeutic protein known as ... www.generex.com ), a biotechnology company developing a buccal ... in a Phase III trial, today are making ...
... AMSTERDAM, The Netherlands, August 4, 2011 SynCo ... of biopharmaceuticals today announced that its aseptic filling facility is ... first drug product batches for its clients after the expansion ... of the Class A zone is an important milestone in ...
Cached Biology Technology:Biodel Reports Third Quarter Fiscal Year 2011 Financial Results 2Biodel Reports Third Quarter Fiscal Year 2011 Financial Results 3Biodel Reports Third Quarter Fiscal Year 2011 Financial Results 4Biodel Reports Third Quarter Fiscal Year 2011 Financial Results 5Biodel Reports Third Quarter Fiscal Year 2011 Financial Results 6Amarantus BioSciences and Generex Biotechnology Collaborate on Cell Therapy for Late Stage Diabetes 2Amarantus BioSciences and Generex Biotechnology Collaborate on Cell Therapy for Late Stage Diabetes 3Amarantus BioSciences and Generex Biotechnology Collaborate on Cell Therapy for Late Stage Diabetes 4Amarantus BioSciences and Generex Biotechnology Collaborate on Cell Therapy for Late Stage Diabetes 5SynCo Bio Partners Expands the Class A Zone in its Aseptic Filling Facility 2
Agarose-ME, 500 g. Suitable for immunoelectrophoresis.Gel point (1.5%): 36 1.5 C, EEO (-mr): 0.16-0.19, Gel strength (1%): > 1000 g/cm2. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Bio...
... while maintaining high cell viability , ... , Fast: less than one ... , Highly reproducible results from ... with the Bio-Rad Gene Pulser Xcell System ...
100 adhesive strips....
Request Info...
Biology Products: