Navigation Links
Percutaneous aortic valve replacement safe, successful in high-risk patients

Catheter techniques are expanding into new territory, successfully aiding in the replacement of narrowed, calcified aortic valves in patients too sick to withstand open-chest surgery. According to a study reported at the 30th Annual Scientific Sessions of the Society for Cardiovascular Angiography and Interventions (SCAI), May 9?2, 2007, in Orlando, FL, patients who were treated with the CoreValve Revalving System (CoreValve, Irvine, CA) experienced improvements in both the size of the aortic valve and in the severity of heart failure.

To evaluate the CoreValve system, Anita Asgar, M.D., and her colleagues at Montreal Heart Institute recruited 17 elderly patients with a severely narrowed aortic valve, all of whom had been turned down for surgery because of other health problems. In severe narrowing, or stenosis, of the aortic valve, the heart has difficulty pumping blood from the left ventricle to the rest of the body. The result is a back-up of fluid into the lungs and severe shortness of breath with even minimal activity.

With the CoreValve system, aortic valve replacement is performed by threading a special delivery catheter through the femoral artery in the groin and into the aorta in a direction opposite, or retrograde, to the normal flow of blood. Once the catheter is properly positioned in the opening of the aortic valve, it is pulled back to release the CoreValve, a self-expanding stent-like frame with the new tissue valve attached to its core. As it expands, the CoreValve covers the diseased natural valve leaflets.

During the procedure, the patients were placed on a bypass pump for an average of 30?0 minutes to minimize blood flow through the aorta and ease placement of the replacement valve.

All 17 patients survived the procedure. One patient died 5 days later from stroke. Five additional patients died after discharge from the hospital from health problems unrelated to the replacement valve. Follow-up in the 11 survi vors showed that the average aortic valve area more than doubled, on average, following the procedure. In addition, the severity of heart failure significantly improved, as gauged by both B-type natriuretic peptide (NT-BNP), a protein produced by the ventricles of the heart during heart failure, and New York Heart Association (NHYA) classification. After the procedure, patients were ranked in NYHA class II, on average, suggesting most were able to engage in a moderate level of activity before becoming short of breath.

Source:Society for Cardiovascular Angiography and Interventions

Related biology news :

1. Edible bivalves as a source of human pathogens: signals between vibrios and the bivalve host.
2. Bone and cartilage growth to blame for heart valve disease
3. Findings advance use of adult stem cells for replacement bone
4. Genes may determine success of hip replacement surgery
5. Results of worlds first gene therapy trial for arthritis show approach safe, feasible
6. Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned
7. New, automated tool successfully classifies and relates proteins in unprecedented way
8. Biomarkers isolated from saliva successfully predict oral and breast cancer
9. UN successfully tests green pesticide against locusts
10. Stem cell therapy successfully treats heart attack in animals
11. Mad cow proteins successfully detected in blood

Post Your Comments:

(Date:5/3/2016)... 3, 2016  Neurotechnology, a provider of high-precision ... Automated Biometric Identification System (ABIS) , a complete ... MegaMatcher ABIS can process multiple complex biometric transactions ... of fingerprint, face or iris biometrics. It leverages ... and MegaMatcher Accelerator , which have been ...
(Date:4/19/2016)... , UAE, April 20, 2016 ... implemented as a compact web-based "all-in-one" system solution for ... biometric fingerprint reader or the door interface with integration ... modern access control systems. The minimal dimensions of the ... readers into the building installations offer considerable freedom of ...
(Date:3/31/2016)... 2016   LegacyXChange, ... "Company") LegacyXChange is excited to release its ... to be launched online site for trading 100% guaranteed ... will also provide potential shareholders a sense of the ... an industry that is notorious for fraud. The video ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical journal articles ... findings are the subject of a new article on the Surviving Mesothelioma website. ... blood, lung fluid or tissue of mesothelioma patients that can help point doctors to ...
(Date:6/23/2016)... ... June 23, 2016 , ... UAS ... the launch of their brand, UP4™ Probiotics, into Target stores nationwide. The company, ... proud to add Target to its list of well-respected retailers. This list includes ...
(Date:6/23/2016)... June 23, 2016 /PRNewswire/ - FACIT has announced ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" ... commercialization of a portfolio of first-in-class WDR5 inhibitors ... such as WDR5 represent an exciting class of ... precision medicine for cancer patients. Substantial advances have ...
(Date:6/23/2016)... HOUSTON , June 23, 2016 ... agreement with the Cy-Fair Sports Association to serve ... of the agreement, Houston Methodist Willowbrook will provide ... education and connectivity with association coaches, volunteers, athletes ... partner with the Cy-Fair Sports Association and to ...
Breaking Biology Technology: