Navigation Links
Penn researchers study the use of ultrasound for treatment of cancer

For the first time, ultrasound is being used in animal models ?to treat cancer by disrupting tumor blood vessels. Researchers at the University of Pennsylvania School of Medicine completed a study in mice in which they used ultrasound both to see a tumor's blood perfusion and then to treat it with a continuous wave of low-level ultrasound. After three minutes of treatment at an intensity similar to what is used in physiotherapy ultrasound (about 2.5 watts), researchers observed that the tumors had little or no blood supply.

"We used an ultrasound intensity higher than that used for imaging, but much lower than the high intensities used to ablate tissue. And we saw that this new use had a profound effect on shutting down the blood flow to the tumor and reducing the growth of the tumor in mice," said Chandra Sehgal, PhD, Director of Ultrasound Research in the Department of Radiology at Penn and the study's principal investigator.

"We wanted to study this use of ultrasound because we observed that some of these newly formed vessels created by tumors are very weak in nature, and if you turn on low-intensity ultrasound vibrations you can disrupt the blood flow through these vessels," explained Andrew Wood, DVSc, PhD, a co-investigator of the study and based in the University of Pennsylvania School of Veterinary Medicine.

Sehgal adds, "This approach is in keeping with the latest study of cancer treatment utilizing antiangiogenic and antivascular therapies, in which we look for ways to stop the growth of the vessels supplying blood and nutrition to the tumors, rather than develop methods to kill the tumor cells themselves."

For years, ultrasound has been used for clinical imaging and for therapeutic action in physical therapy. But now, Sehgal explains, "These results are extremely encouraging. They raise the possibility that, in the future, treatments with ultrasound either alone or with chemotherapeutic and antivascular agents could be used to treat cancers."


'"/>

Source:University of Pennsylvania School of Medicine


Related biology news :

1. NYU researchers simulate molecular biological clock
2. Vital step in cellular migration described by UCSD medical researchers
3. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
4. UCSD researchers maintain stem cells without contaminated animal feeder layers
5. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
6. New protein discovered by Hebrew University researchers
7. First real-time view of developing neurons reveals surprises, say Stanford researchers
8. Agilent Technologies releases automated literature search tool for biology researchers
9. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
10. Yale researchers identify molecule for detecting parasitic infection in humans
11. US life expectancy about to decline, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/9/2016)... 2016  Perkotek an innovation leader in attendance control systems is proud to announce ... for employers to make sure the right employees are actually signing in, and to ... ... ... ...
(Date:6/2/2016)... --  The Weather Company , an IBM Business (NYSE: ... in which consumers will be able to interact with IBM ... voice or text and receive relevant information about the product ... have long sought an advertising solution that can create a ... and valuable; and can scale across millions of interactions and ...
(Date:5/16/2016)... , May 16, 2016   EyeLock LLC , ... announced the opening of an IoT Center of Excellence ... and expand the development of embedded iris biometric applications. ... level of convenience and security with unmatched biometric accuracy, ... identity aside from DNA. EyeLock,s platform uses video technology ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. ... the faculty of the University of North Carolina Kenan-Flagler Business School ... entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s international efforts, leading ...
(Date:6/27/2016)... , June 27, 2016   Ginkgo Bioworks , ... industrial engineering, was today awarded as one of ... of the world,s most innovative companies. Ginkgo Bioworks ... for the real world in the nutrition, health ... work directly with customers including Fortune 500 companies ...
(Date:6/24/2016)... , June 24, 2016 Epic Sciences ... detects cancers susceptible to PARP inhibitors by targeting ... cells (CTCs). The new test has already been ... in multiple cancer types. Over 230 ... damage response pathways, including PARP, ATM, ATR, DNA-PK ...
(Date:6/24/2016)... ... , ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical ... mesothelioma. Their findings are the subject of a new article on the Surviving Mesothelioma ... in the blood, lung fluid or tissue of mesothelioma patients that can help point ...
Breaking Biology Technology: