Navigation Links
Penn researchers replace organ in adult mice using 'single-parent' stem cells

Researchers at the University of Pennsylvania School of Veterinary Medicine have derived uniparental embryonic stem cells - created from a single donor's eggs or two sperm - and, for the first time, successfully used them to repopulate a damaged organ with healthy cells in adult mice. Their findings demonstrate that single-parent stem cells can proliferate normally in an adult organ and could provide a less controversial alternative to the therapeutic cloning of embryonic stem cells.

"Creating uniparental embryonic stem cells is actually much more efficient than generating embryonic stem cells by cloning," said K. John McLaughlin, an assistant professor in Penn's Department of Animal Biology and researcher at the Center for Animal Transgenesis and Germ Cell Research at Penn's New Bolton Center. "The fact that we are not destroying a viable embryo in the process also avoids certain ethical issues that currently surround embryonic stem cell science."

McLaughlin and his colleagues report their findings in the Feb. 15 issue of the journal Genes & Development.

"While previous research has approached the possibility of using a woman's egg cells to create therapeutic stem cells, we discovered that we could actually repopulate an adult organ. To our surprise we also found that by using male-only derived embryonic stem cells, we could do the same," McLaughlin said. "In humans, this could provide a therapeutic route for both genders; members of either sex can use this technique to produce compatible stem cells, much like you might donate blood for your own use in advance of an operation."

Parthenogenesis, the act of creating an embryo without fertilization, is common in some plants, insects and animals, including the recent and celebrated case of the "virgin birth" of a komodo dragon in England. Humans and all other mammals, however, require two sets of chromosomes - one from each parent - to create a functioning embryo.Accordi
'"/>

Source:University of Pennsylvania


Page: 1 2 3

Related biology news :

1. NYU researchers simulate molecular biological clock
2. Vital step in cellular migration described by UCSD medical researchers
3. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
4. UCSD researchers maintain stem cells without contaminated animal feeder layers
5. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
6. New protein discovered by Hebrew University researchers
7. First real-time view of developing neurons reveals surprises, say Stanford researchers
8. Agilent Technologies releases automated literature search tool for biology researchers
9. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
10. Yale researchers identify molecule for detecting parasitic infection in humans
11. US life expectancy about to decline, researchers say
Post Your Comments:
(Date:12/17/2014)... , Dec. 15, 2014 The Defense Logistics Agency ... detect and prevent counterfeit microcircuits from entering into its ... an in-house microcircuit anti-counterfeit initiative dubbed DNA marking. The ... increasing their reliability throughout the supply chain. The new ...
(Date:12/17/2014)... Dec. 16, 2014 Research and Markets ( ... "Global Chemical Sensor Market 2015-2019" report to their ... One major trend upcoming in this market is ... Chemical sensors help in recording of patient data for ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of ...  report to their offering. One major ... With continuous advances in technology, it is important to ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... Two USC scientists have developed an algorithm that could help ... be useful to researchers of all stripes. Andrew Smith, ... Arts and Sciences, developed the algorithm along with USC graduate ... more DNA, to be published in Nature Methods ...
... found a new way to accelerate a workhorse instrument that ... and point to new drugs for treating a wide range ... used in muscle, brain, blood and hormones. If the genes ... hammers and tongs of life. Proteins are not only ...
... articles posted online ahead of print on 20 Feb. 2013 ... on the Exmouth Sub-basin, Australia; the West Kunlun Range, northern ... hot springs of Colorado. The 12 new papers cover a ... to Earth,s surface, A challenge to climate change and biotic ...
Cached Biology News:Taking the gamble out of DNA sequencing 2Analytical trick accelerates protein studies 2Analytical trick accelerates protein studies 3Color in fossil insects, diamonds from the ancient ocean floor and modeling the world's largest rivers 2Color in fossil insects, diamonds from the ancient ocean floor and modeling the world's largest rivers 3Color in fossil insects, diamonds from the ancient ocean floor and modeling the world's largest rivers 4Color in fossil insects, diamonds from the ancient ocean floor and modeling the world's largest rivers 5Color in fossil insects, diamonds from the ancient ocean floor and modeling the world's largest rivers 6Color in fossil insects, diamonds from the ancient ocean floor and modeling the world's largest rivers 7Color in fossil insects, diamonds from the ancient ocean floor and modeling the world's largest rivers 8Color in fossil insects, diamonds from the ancient ocean floor and modeling the world's largest rivers 9Color in fossil insects, diamonds from the ancient ocean floor and modeling the world's largest rivers 10Color in fossil insects, diamonds from the ancient ocean floor and modeling the world's largest rivers 11
(Date:1/22/2015)... CAMBRIDGE, Mass. , Jan. 22, 2015   GenoSpace , ... suite of tools to enable the broad use of genomic, ... today announced the appointment of Michelle Munson , CEO ... independent director. Logo - http://photos.prnewswire.com/prnh/20150122/170713 ...
(Date:12/25/2014)... report “Service Quality Management and Telco Customer Experience Management ... Advancements, Worldwide Forecasts & Analysis (2014-2019)” defines and segments ... revenues. , Browse 152 market data tables, 19 ... “Service Quality Management (SQM) and Telco Customer Experience Management ...
(Date:12/24/2014)... NEW YORK , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, ... in critical areas, announced the closing of an underwritten public ... purchase up to an aggregate 3,500,000 shares of common stock, ... per warrant.  The warrants have a per share exercise price ...
(Date:12/24/2014)... BOTHELL, Wash. , Dec. 24, 2014   BioLife Solutions ... manufacturer and marketer of proprietary clinical grade hypothermic storage ... thermal shipping products for cells and tissues  ("BioLife" or ... Annual Meeting of Stockholders on May 4, 2015 (the "Annual ...
Breaking Biology Technology:GenoSpace Expands Board with Appointment of Michelle Munson 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3BioLife Solutions Sets Date for Annual Meeting of Stockholders 2
... , , , , , , , , ... Type of primers , Primer anneal. temp. , ... in RT , GC-rich structures , Product , ... total RNA , viral RNA , , ...
... , , , , ... Primer anneal. temp. , Sensitivity , Specifi- , ... Tolerance , of non- , specific RNA , ... of serum components , Carry-over , prevention dUTP/UNG ...
... , , , , , , ... Maximum size of template , Temperature optimum , ... ment , Rnase H activity , Combined RT ... , Expand Re- , verse Trans- , ...
Cached Biology Technology:Reverse transcriptases suitable for two-step RT-PCRd 2Reverse transcriptases suitable for two-step RT-PCRd 3Reverse transcriptases suitable for one-step RT-PCRb 2Properties of Reverse Transcriptases 2
... and compact GC-8A is Shimadzu's basic gas ... simple to use, the GC-8A supports a ... on column injection port(s), and analog output. ... are available. The GC-8A is only 17.3 ...
... infusion kits reduce the time and expense ... providing sterile equipment to reduce the risk ... need for one animal, including swivel, tubing, ... be cut to the exact lengths you ...
The novel and unique HCTplus delivers unmatched information-rich data-dependent LC/MSn data for todays challenge in proteomics and metabonomics work....
... an exciting new chapter to ... leadership, Agilents 7890A GC gives ... take your lab to the ... GC/MS performance, including advanced separation ...
Biology Products: