"Creating uniparental embryonic stem cells is actually much more efficient than generating embryonic stem cells by cloning," said K. John McLaughlin, an assistant professor in Penn's Department of Animal Biology and researcher at the Center for Animal Transgenesis and Germ Cell Research at Penn's New Bolton Center. "The fact that we are not destroying a viable embryo in the process also avoids certain ethical issues that currently surround embryonic stem cell science."
McLaughlin and his colleagues report their findings in the Feb. 15 issue of the journal Genes & Development.
"While previous research has approached the possibility of using a woman's egg cells to create therapeutic stem cells, we discovered that we could actually repopulate an adult organ. To our surprise we also found that by using male-only derived embryonic stem cells, we could do the same," McLaughlin said. "In humans, this could provide a therapeutic route for both genders; members of either sex can use this technique to produce compatible stem cells, much like you might donate blood for your own use in advance of an operation."
Parthenogenesis, the act of creating an embryo without fertilization, is common in some plants, insects and animals, including the recent and celebrated case of the "virgin birth" of a komodo dragon in England. Humans and all other mammals, however, require two sets of chromosomes - one from each parent - to create a functioning embryo.Accordi
Source:University of Pennsylvania