Navigation Links
Penn researcher shows that DNA gets kinky easily at the nanoscale

Scientists have answered a long-standing molecular stumper regarding DNA: How can parts of such a rigid molecule bend and coil without requiring large amounts of force? According to a team of researchers from the United States and the Netherlands, led by a physicist from the University of Pennsylvania, DNA is much more flexible than previously believed when examined over extremely small lengths. They used a technique called atomic force microscopy to determine the amount of energy necessary to bend DNA over nano-size lengths (about a million times smaller than a printed letter).

The findings, which appear in the November issue of the journal Nature Nanotechnology, illustrate how molecular properties often appear different when viewed at different degrees of magnification.

"DNA is not a passive molecule. It constantly needs to bend, forming loops and kinks, as other molecules interact with it," said Philip Nelson, a professor in Penn's Department of Physics and Astronomy in the School of Arts and Sciences. "But when people looked at long chunks of DNA, it always seemed to behave like a stiff elastic rod."

For example, DNA must wrap itself around proteins, forming tiny molecular structures called nucleosomes, which help regulate how genes are read. The formation of tight DNA loops also plays a key role in switching some genes off. According to Nelson, such processes were considered a minor mystery of nature, in part because researchers didn't have the tools of nanotechnology to examine molecules in such fine detail.

"Common sense and physics seemed to tell us that DNA just shouldn't spontaneously bend into such tight structures, yet it does," Nelson said. "In the conventional view of a DNA molecule, wrapping DNA into a nucleosome would be like bending a yardstick around a baseball."

To study DNA on the needed short length scales, Nelson and his colleagues used a technique called high-resolution atomic force micros
'"/>

Source:University of Pennsylvania


Page: 1 2

Related biology news :

1. U of M researcher examines newly emerging deadly disease
2. NYU researchers simulate molecular biological clock
3. Vital step in cellular migration described by UCSD medical researchers
4. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
5. UCSD researchers maintain stem cells without contaminated animal feeder layers
6. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
7. New protein discovered by Hebrew University researchers
8. First real-time view of developing neurons reveals surprises, say Stanford researchers
9. Agilent Technologies releases automated literature search tool for biology researchers
10. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
11. Yale researchers identify molecule for detecting parasitic infection in humans
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Penn researcher shows that DNA gets kinky easily the nanoscale

(Date:7/31/2015)... La 10 th International Conference on Genomics ... 22 al 25 de octubre de 2015 en ... conferencia celebra su décimo aniversario. Desde su inauguración en el ... reuniones anuales más influyentes del mundo en el campo ,ómico, ... y mejores a nivel científico. ICG-10 se ...
(Date:7/30/2015)... 2015 Cellecta, Inc., a U.S.-based provider ... and biomarker discovery, announced the release of its ... all human protein coding genes. CRISPR technology enables ... gene,s function. Cellecta,s new Human Whole Genome CRISPR ... so that researchers can investigate in a single ...
(Date:7/23/2015)... July 23, 2015 Research and Markets ... the "Global Outlook of the Biometrics Industry ... The global biometrics market is likely ... commercial applications owing to the uptake of multiple ... transformation that enhances the growth of biometrics in ...
Breaking Biology News(10 mins):La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3
... the nature of crowds playing Foldit called some strategies ... methods already used by protein scientists., Gamers made headlines ... central to research on AIDS. Today, in a ... National Academy of Sciences, University of Washington researchers ...
... 2011 AVT, Inc. (formerly Automated Vending Technologies) (Ticker: ... provide a new line of Secure Automated Retailing Systems ... This new system provides extra security for automated ... customer is critical. AVT worked with ...
... characterize the genes involved in wood formation in poplar trees ... wood as a feedstock for biofuels production. "This ... work of other biofuels researchers who develop better and more ... Beers, professor of horticulture and the lead investigator on the ...
Cached Biology News:Paper uncovers power of Foldit gamers' strategies 2Paper uncovers power of Foldit gamers' strategies 3AVT Partners with MedBox to Provide New Biometric Fingerprint Recognition for Secure Automated Retailing 2Genomics of wood for biofuels production investigated 2
(Date:7/30/2015)... ... July 30, 2015 , ... ... field clinical study of its canine osteoarthritis stem cell product, currently under development ... City, KS) and will be marketed in the US by Aratana. This product, ...
(Date:7/30/2015)... customers across the globe, ISN improves the efficiency and effectiveness of contractor management systems. ... and reliable contractors in over 80 countries. ... ... Over 60,000 Worldwide Customers In More Than 80 Countries ... Headquartered in Dallas, TX , ISN has additional offices in ...
(Date:7/30/2015)... Pa. , July 30, 2015  Discovery ... that it has received the second $1.0M tranche ... Innovation Research (SBIR) grant valued at up to ... company,s aerosolized KL4 surfactant as a potential medical ... injury.  Discovery Labs was awarded an initial $1.0 ...
(Date:7/29/2015)... Sanofi, a global and ... quarter of 2015. CEO Olivier Brandicourt ... in different businesses. Watch video interview ... Topics covered in the interview include:  ... Performance drivers - Diabetes ...
Breaking Biology Technology:VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 3ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3
... U.S. Secretary of Health and Human Services Tommy Thompson has ... , a provider of information systems for high-acuity care areas ... room and the intensive care unit. , ,Thompson began his ... Wisconsin's state Assembly. He was elected assistant Assembly minority leader ...
... has approved a $500,000 start-up grant for the ... group for classified, defense-related projects. , ,The ... also initially include the UW System, the Medical ... and the Milwaukee School of Engineering. , ,The ...
... National LambdaRail Two UW-Madison computer science professors, ... have been named to the National LambdaRails Networking Researching ... the high-speed fiber optic networks research goals. , ,The ... educational groups across the country, which over the past ...
Cached Biology Technology:Wisconsin consortium aims for defense business 2Two UW-Madison professors named to National LambdaRail Networking Research Council 2
... enables complete conversion of unmethylated cytosines ... hours. The highly sensitive method utilizes ... and a spin-column-based purification and desulfonation ... results for all downstream applications. The ...
... Shimadzus GCMS-QP2010s Gas Chromatograph/Mass Spectrometer, ... of the GCMS-QP2010 Plus, offers high ... with an excellent performance-to-cost ratio. Like ... patented constant linear velocity for optimum ...
... enterprise microarray informatics platform for microarray data storage, ... and use it forever without paying ongoing license ... Acuity has all the analysis tools you need ... quality control statistics and normalization, all the way ...
... Pro is the industry standard microarray image ... of imaging and analysis tools, visualizations, automation ... Pro is included with every GenePix scanner, ... third-party scanners and all types of arrays. ...
Biology Products: