Navigation Links
Patterns in genome organization may partially explain how microbial cells work

The location of a piece of real estate may be its most important feature to many Realtors, and bioengineering researchers at the University of California, San Diego (UCSD) and the University of Virginia have reported that the location of genes and other features distributed along the chromosomes of bacteria and simpler organisms also is fundamentally important to how microbial cells operate.

In a paper published Jan. 13 online in PLoS Computational Biology, the researchers reported large- and small-scale organizational patterns in the genomes of 135 bacteria ranging from those that cause typhoid fever and various other human infections to organisms that enrich the nitrogen content of soil. In addition, 16 more primitive microorganisms, including one that thrives in boiling hot springs, also exhibit patterns in their genomes that are highly nonrandom.

"This high degree of organization of prokaryotic genomes is a complete surprise, and this finding carried many implications that biologists might not have considered before," said Bernhard Palsson, a professor of bioengineering at UCSD's Jacobs School of Engineering and adjunct professor of medicine and co-author of the analysis. "These findings show that evolution of prokaryotes [organisms that lack nuclei] is constrained not just by variations in the content of genes, but also by the intricate ways in which those genes are arranged on chromosomes."

A bacterial cell usually operates with one copy of its genome. Until 2002, there had been no way to determine if a particular gene or area of the chromosome was segregated in any particular way inside the cell. New techniques that attach fluorescent "reporter" markers to predetermined spots on chromosomes have indicated that many bacterial genes tend to be found at specific cellular locations. Patterns are not obvious in the sequences of prokaryotic genomes, which led the team led by Palsson to use signal-processing methods to identify long-range spat
'"/>

Source:University of California - San Diego


Page: 1 2 3

Related biology news :

1. Man and mouse share genome structures
2. Whole genome fine map of rice completed
3. Study finds more than one-third of human genome regulated by RNA
4. A bacterial genome reveals new targets to combat infectious disease
5. Scientists decipher genome of fungus that can cause life-threatening infections
6. Highly adaptable genome in gut bacterium key to intestinal health
7. Fleshing out the genome
8. Agilent Technologies new genome analysis technology set to accelerate Australia fight against mesothelioma
9. wFleaBase: the Daphnia genome database
10. NHGRI targets 12 more organisms for genome sequencing
11. Chimp genome reveals a retroviral invasion
Post Your Comments:
(Date:4/17/2015)... 17, 2015 Increasing ... technological advancement to drive biometric systems market in ...   According to a recently released ... &  Opportunities, 2020 ", biometric systems market in ... growth at CAGR of over 22% through 2020. ...
(Date:4/14/2015)... , April 14, 2015 NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... nominated for the 2015 New York Design Awards under ... Design100, New York City Design Awards are part of ... on over 2,500 ratings from the marketplace, industry and ...
(Date:4/13/2015)... CHICAGO , April 13, 2015  higi, a ... with ways to more fully engage with their communities ... its industry-leading, privacy protected and secure API.  ... API enables the most accessible, affordable, and convenient vehicle ... The API will ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
... 11, 2010) Advancement in the treatment of cocaine overdoses ... just two examples of the groundbreaking research that will be ... Biotechnology Conference (NBC). The conference takes place Sunday, May 16 ... in San Francisco, Calif. A Possible ...
... Arts and Sciences has received a $9.5 million grant ... Cluster in Genome Structure and Developmental Patterning in Health ... such areas as genome structure and stability, developmental and ... to organism" research to advance treatment of hereditary diseases, ...
... LA JOLLA, Calif., May 11, 2010 -- Cancer uses ... example is the way tumors express anti-cell death (anti-apoptotic) ... laboratory at Sanford-Burnham Medical Research Institute (Sanford-Burnham) has made ... proteins and make current treatments more effective. In ...
Cached Biology News:Biotherapeutic Innovations on Display at AAPS National Biotechnology Conference 2Tufts wins NCRR grant for Collaborative Cluster in Genome Structure and Developmental Patterning 2Tufts wins NCRR grant for Collaborative Cluster in Genome Structure and Developmental Patterning 3Cancer: Trapping the escape artist 2
(Date:5/1/2015)... Albany Molecular Research Inc. (NASDAQ: AMRI ... AMRI,s President and Chief Executive Officer, will present at ... Conference on Wednesday, May 13, 2015 at 4:20 p.m. ... presentation can be accessed at AMRI,s Investor Relations web ... will be archived for 90 days following the live ...
(Date:4/30/2015)... April 30, 2015  Roka Bioscience, Inc. (NASDAQ: ... advanced testing solutions for the detection of foodborne pathogens, ... first quarter of 2015 on May 7, 2015 after ... Bioscience will also host a conference call at 4:30 ... its first quarter financial results. During the conference call, ...
(Date:4/30/2015)... (PRWEB) April 30, 2015 Nitto ... today announces its increased capacity and production capability ... increased client variety and service fulfillment continues to ... improve process throughput capacities. , ... newly installed downstream process equipment at its Milford, ...
(Date:4/30/2015)... , April 30, 2015  The Paul G. Allen ... Investigator (ADI) grants to six groups of researchers with ... challenging roadblocks in neuroscience: growing mature human brain cells ... total of $7.5 million over three years.  ... their research is especially significant because the field of ...
Breaking Biology Technology:AMRI to Present at the Bank of America Merrill Lynch 2015 Health Care Conference 2Roka Bioscience to Report First Quarter 2015 Financial Results On May 7, 2015 2Biotechnology Manufacturer Nitto Avecia Expands Capacity to Meet Client Demand 2The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 2The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 3The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 4The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 5
... Universite de Montreal and Validapro Biosciences Inc. have signed an ... standards of the biotherapeutic manufacturing unit located at the Faculty ... veterinary clinical use. , ... Laval, ...
... 19 , - Completed ... Opsona Therapeutics, a biotechnology company focused ... diseases, today,announced that Roche Venture Fund and Enterprise Ireland ... financing announced in February,this year, bringing the total round ...
... for Mometasone Furoate/Formoterol Combination for Asthma and ... (NYSE: SGP ) today announced ... for the development and commercialization of fixed-dose ... and chronic obstructive pulmonary disease (COPD). ...
Cached Biology Technology:Roche Venture Fund, Enterprise Ireland Commit EUR3.3 M to Opsona Series B Financing 2Roche Venture Fund, Enterprise Ireland Commit EUR3.3 M to Opsona Series B Financing 3Schering-Plough Announces Changes to its Global Collaboration with Novartis to Develop Combination Therapies for Asthma and COPD 2Schering-Plough Announces Changes to its Global Collaboration with Novartis to Develop Combination Therapies for Asthma and COPD 3Schering-Plough Announces Changes to its Global Collaboration with Novartis to Develop Combination Therapies for Asthma and COPD 4Schering-Plough Announces Changes to its Global Collaboration with Novartis to Develop Combination Therapies for Asthma and COPD 5Schering-Plough Announces Changes to its Global Collaboration with Novartis to Develop Combination Therapies for Asthma and COPD 6Schering-Plough Announces Changes to its Global Collaboration with Novartis to Develop Combination Therapies for Asthma and COPD 7Schering-Plough Announces Changes to its Global Collaboration with Novartis to Develop Combination Therapies for Asthma and COPD 8
Size & Applications: 100 ul (2 mM). Recommend to use at 1000X dilutions for cell culture (e.g. Add 1 ul to 1 ml of culture medium.) Storage Temp.: -20C Shelf Life: 6-12 month...
in vitro Translation, Accessory Products...
Request Info...
... The Zero Blunt ... for Sequencing is designed ... sequencing of blunt-end PCR ... provides 5-minute TOPO Cloning ...
Biology Products: