Navigation Links
Pathway toward gene silencing described in plants

Biologists at Washington University in St. Louis have made an important breakthrough in understanding a pathway plant cells take to silence unwanted or extra genes using short bits of RNA. Basically, they have made it possible to see where, and how, the events in the pathway unfold within the cell, and seeing is believing, as the old saying goes.

Craig Pikaard, Ph.D., Washington University professor of biology in Arts & Sciences and his collaborators have described the roles that eight proteins in Arabidopsis plants play in a pathway that brings about DNA methylation, an epigenetic function that involves a chemical modification of cytosine, one of the four chemical subunits of DNA. Without proper DNA methylation, higher organisms from plants to humans have a host of developmental problems, from dwarfing in plants to certain tumors in humans, and death in mice. One role of DNA methylation is to turn off repetitive genes, such as transposable elements that can move or spread throughout a genome and disrupt other gene functions if left unchecked. There is also interest in DNA methylation because understanding how some genes are selectively silenced and how silenced alleles can be turned on again may someday have practical benefits. For instance, tumor suppressor genes that normally help keep cells from dividing uncontrollably are often silenced by DNA methylation and histone (proteins that wrap DNA) modifications in cancer cells, contributing to tumor growth. And certain blood disorders resulting from defective genes expressed in adults might be alleviated if versions of those same genes that are only expressed very early in development, but are then silenced in adults, could only be turned on again.

"The pathway we are studying is part of an interesting phenomenon that occurs in plants, and reportedly in humans, too, called RNA-directed DNA methylation," Pikaard explained. "This pathway takes place in the nucleus, and it involves short RNA
'"/>

Source:Washington University in St. Louis


Page: 1 2 3 4

Related biology news :

1. Breast Cancer May Be Uniquely Sensitive To Inhibitors Of PI3K Pathway
2. Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol
3. Ariadne Genomics Announces the Release of PathwayStudio?Central, Client-Server Software for Biological Pathway Analysis
4. Unchecked DNA replication drives earliest steps toward cancer
5. Virologists make major step towards understanding the process of HIV infection
6. Moffitt-USF head toward first human trials of anti-cancer drug that targets protein AKT
7. Cats indifference towards sugar explained
8. A step toward the $1,000 personal genome using readily available lab equipment
9. A new step towards an AIDS vaccine
10. New GM mosquito sexing technique is step towards malaria control, report scientists
11. Novel method reveals how menthol discovery could point towards new or improved pain therapies
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Pathway toward gene silencing described plants

(Date:2/5/2015)... , Jan. 30, 2015  It is gratifying to ... and potential for genomic science as a means to ... prevention and treatment.  I was honored to participate in ... precision medicine program. Since the 1980s ... of genomics—from the first sequenced genome of a free ...
(Date:1/22/2015)... 13, 2015  Today, FreeWavz ( www.FreeWavz.com ), the ... campaign on Fundable, https://www.fundable.com/freewavz . FreeWavz will ... capacity to meet customer demand. Logo ... http://photos.prnewswire.com/prnh/20150113/168790 Invented by Dr. ...
(Date:1/22/2015)... POINT ROBERTS, Washington , January 20, 2015 ... sectors including technology and tech stocks, releases video from the ... pickpocket and security consultant Apollo Robbins . ... about the Wocket™ biometric smart wallet, a product of NXT-ID, ...
Breaking Biology News(10 mins):J. Craig Venter, Ph.D., Co-Founder and CEO, Human Longevity, Inc. (HLI) Participates in White House Precision Medicine Event 2FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3
... Administering stem cells derived from patients, own bone marrow either ... but does not improve heart function six months later, according ... Health (NIH). The results of the trial, called ... study, LateTIME, which found that such cells (called autologous stem ...
... factors responsible for symptoms such as headaches, gastro-intestinal disorders, ... unconsciousness and cardiac arrhythmia in severe cases. Histamine, one ... cause serious physical problems. Biogenic amines can be produced ... also ingested in larger quantities with food. They play ...
... developed a low-cost solution that could control the fungal disease ... tests are being carried out at Imperial College London,s Silwood ... The fungus Chalara fraxinea entered the country via ... led to the destruction of an estimated 100,000 diseased saplings ...
Cached Biology News:Bone marrow stem cells do not improve short-term recovery after heart attack 2Bone marrow stem cells do not improve short-term recovery after heart attack 3Development of measures to prevent wine indispositions 2Researchers test solution to fungal disease of ash trees 2Researchers test solution to fungal disease of ash trees 3
(Date:2/26/2015)... (NASDAQ: ONCE ) announced today that members ... and Company Health Care Conference on Wednesday, March 4, ... Copley Place. To access the live webcast ... please visit the "Upcoming Events" section within the "News ... www.sparktx.com .  A replay of the webcast will ...
(Date:2/26/2015)... 26, 2015 On Wednesday, February 25, ... a nationwide Clostridium difficile (C. diff) awareness movement, lauded ... study by the Centers for Disease Control & Prevention ... half a million infections among Americans in a single ... , The study also estimates that 29,000 patients ...
(Date:2/26/2015)... , February 26, 2015 ... into PEACH, the first pivotal trial of PT20 ... chronic kidney disease (DD-CKD), has completed as the ... PT20, invented by leading UK-based scientists from ... Phosphate Therapeutics, is a novel phosphate binder that ...
(Date:2/25/2015)... Calif. , Feb. 25, 2015 ... nootropic drink, is featured in this week,s Power ... cnbc.com/id/102454724 , to discuss the company,s traction and ... offering through the crowd funding site CircleUp. ... novel products that are validated by neurotechnology, while ...
Breaking Biology Technology:Spark Therapeutics to Participate in the 35th Annual Cowen and Company Health Care Conference 2Peggy Lillis Foundation Lauds CDC's New, More Comprehensive Study on the Burden of C. difficile Infections in the United States 2Peggy Lillis Foundation Lauds CDC's New, More Comprehensive Study on the Burden of C. difficile Infections in the United States 3Peggy Lillis Foundation Lauds CDC's New, More Comprehensive Study on the Burden of C. difficile Infections in the United States 4Phosphate Therapeutics Announces Completion of Subject Recruitment Into the PEACH Pivotal Phase 2 Study of its Novel Phosphate Binder (PT20) for the Treatment of Hyperphosphataemia 2Phosphate Therapeutics Announces Completion of Subject Recruitment Into the PEACH Pivotal Phase 2 Study of its Novel Phosphate Binder (PT20) for the Treatment of Hyperphosphataemia 3CNBC's Power Lunch Features Neurotechnology Start-up truBrain 2
... sales growth, INDIANAPOLIS, April 21 Eli ... financial results for the first quarter of,2008., ... and a pro forma,basis. Reported results were prepared ... include all sales and expenses recognized,by the company ...
... a researcher, please contact the Communications and External Relations staff ... information on ORNL and its research and development activities, please ... a general media-related question or comment, you can send it ... -- Protecting ports . . . , Knowing ...
... April 18 /PRNewswire-FirstCall/ - Angiotech Pharmaceuticals,Inc. (NASDAQ: ... specialty pharmaceutical and,medical device company, today reported ... (NYSE: BSX ) has received approval ... coronary stent system in Canada.,BSC reported that ...
Cached Biology Technology:Lilly Reports Solid First-Quarter Results 2Lilly Reports Solid First-Quarter Results 3Lilly Reports Solid First-Quarter Results 4Lilly Reports Solid First-Quarter Results 5Lilly Reports Solid First-Quarter Results 6Lilly Reports Solid First-Quarter Results 7Lilly Reports Solid First-Quarter Results 8Lilly Reports Solid First-Quarter Results 9Lilly Reports Solid First-Quarter Results 10Lilly Reports Solid First-Quarter Results 11Lilly Reports Solid First-Quarter Results 12Lilly Reports Solid First-Quarter Results 13Lilly Reports Solid First-Quarter Results 14Lilly Reports Solid First-Quarter Results 15Lilly Reports Solid First-Quarter Results 16Lilly Reports Solid First-Quarter Results 17Story tips from the Department of Energy's Oak Ridge National Laboratory, March 2008 2Story tips from the Department of Energy's Oak Ridge National Laboratory, March 2008 3Angiotech's Corporate Partner, Boston Scientific, Reports Canadian Approval for TAXUS(R) Liberte(R) Stent System 2Angiotech's Corporate Partner, Boston Scientific, Reports Canadian Approval for TAXUS(R) Liberte(R) Stent System 3Angiotech's Corporate Partner, Boston Scientific, Reports Canadian Approval for TAXUS(R) Liberte(R) Stent System 4
Rabbit polyclonal to Shigella Immunogen: Mixture of S. boydii, S. flexneri & S. dysenteriae....
... The GSTTag Monoclonal Antibody is a ... affinity to the 26 kDa glutathione-S-transferase ... This purified antibody is suitable for ... sequence expressed in E. coli , ...
... miRCURY Array LNA microarray slides for ... microarray slides incorporate Exiqons unique Locked Nucleic ... and excellent mismatch discrimination for short microRNA ... less than 1 g total RNA (no ...
... Although there have been many modifications to ... defined media, salt solutions still play an important ... to maintain the pH and osmotic balance in ... water and essential inorganic ions, is as valuable ...
Biology Products: