( A molecular ‘battle of the sexes?long c...)Parental genes do what's best for baby

Biologists at The University of Manchester say the prevailing view that maternal and paternal genes compete for supremacy in their unborn offspring fails to answer some important questions relating to child development.

In fact, rather than a parental power struggle, the researchers suggest that certain offspring characteristics can only be explained by their theory of genetic cooperation.

“When we are conceived we inherit two copies of every gene ?one set from our mother and one from our father,?explained Dr Jason Wolf, who led the research in Manchester’s Faculty of Life Sciences.

“But some genes ?through a process called genomic imprinting ?only use one parent’s copy; the spare copy from the other parent is silenced by a chemical stamp.?

The concept of imprinting has long puzzled scientists as it appears to undermine the natural benefits organisms gain from inheriting two sets of genes.

If one copy of a gene is damaged, for instance, then the second copy can compensate; imprinted genes lose this safeguard and so are more susceptible to disease. Errors in imprinting have also been linked to cancer and other genetic disorders.

Scientists have argued that the reason some genes only use or ‘express?one copy is due to a conflict between paternal and maternal interests.

In the natural world, for example, males would hope to produce large offspring to give them the best chance of survival and carry on their gene line. But large offspring require greater maternal investment, so females will try to impose their genetic stamp so that smaller young are born.

“The idea that imprinting evolves because of conflict between males and females over maternal investment in their offspring has become a generally accepted truth that has rem
'"/>

Source:University of Manchester