Navigation Links
Parallel evolution: Proteins do it, too

bine small intestine, making it more efficient at recovering nutrients from bacteria.

Zhang's initial analysis showed that the duplication occurred about four million years ago, some nine million years after the two main groups of colobines---Asian and African---split into separate lineages. To confirm that the duplication occurred after the split, he analyzed DNA samples from an African colobine known as the guereza or colobus monkey.

"We sequenced the gene, and to our surprise we found not one, not two, but three RNASE1 genes," Zhang said. "Further analysis showed that the duplications in African monkeys and Asian monkeys were separate, independent events." Next, Zhang wanted to know if the duplications resulted in similar functional changes in the enzyme. Just as in the Asian colobine, the duplicated genes in African colobines functioned more efficiently at the typical acidity level of the colobine small intestine, he found.

"Then our question was whether the similar functional changes were due to identical amino acid changes at the protein sequence level," Zhang said. "Indeed, we found three amino acid changes that were identical in the two lineages. They occurred independently, but they were identical." Additional experiments confirmed that the three, independent, parallel amino acid changes were responsible for the change in enzyme function.

In both Asian and African colobines, the original, less efficient, gene is not discarded after duplication. But why, Zhang wondered.

"The guess is that the old copy is still doing something important," he said. "RNASE1 has another function, which is to degrade double-stranded RNA. Double-stranded RNA is not normally found in food, but it's found in some viruses, so the old gene may be useful in defending against viral infection." Zhang checked the new and old genes in both lineages and found the same pattern: the new genes have lost the ability to degrade double-stranded RNA, but t
'"/>

Source:University of Michigan


Page: 1 2 3

Related biology news :

1. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
2. Hirsute Or Hairless? Two Proteins May Spell The Difference
3. Proteins stop blood-vessel and tumor growth in mice
4. Proteins spur diabetic mice models to grow blood vessels, nerves
5. Proteins as parents
6. Proteins anchor memories in our brain
7. Proteins may behave differently in natural environments
8. Proteins necessary for brain development found to be critical for long-term memory
9. Proteins may predict lung transplant rejection
10. Proteins important in Alzheimers, Parkinsons disease travel in the slow lane
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Parallel evolution Proteins too

(Date:11/7/2014)... , November 6, 2014 Leading ... for better mobile security revolutionizing online transactions.  Companies in focus ... Holdings Ltd. (NYSE: BABA ), Google Inc. (NASDAQ: ... ), eBay Inc. (NASDAQ: EBAY ) and MasterCard ... NXTD and NXTDW), a biometric authentication company focused on ...
(Date:11/5/2014)... professor of biology in the UTSA College of ... nation selected to receive a two-year $300,00 National ... Research (EAGER). The funding supports President Obama,s BRAIN ... create new technology that will demystify complex brain ... in neuroscience are broken into the interactions of ...
(Date:11/4/2014)... of Medicine announced today that it is a ... the Bill & Melinda Gates Foundation. Laura ... Reproductive Sciences; and Vice Chair of Research and ... will pursue an innovative global health and development ... Fetal Neurodevelopment.", Grand Challenges Explorations (GCE) funds individuals ...
Breaking Biology News(10 mins):Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3Temple University School of Medicine receives Grand Challenges Explorations grant 2
... Queen,s University chemistry professor has invented a special solvent ... Philip Jessop, Canada Research Chair in Green Chemistry, has ... dioxide extracts oil from soybeans. Industries currently make ... is a neurotoxin and creates smog. The process also ...
... A mass spectrometer that will help researchers interpret ... will join other instruments in the Penn State,s ... grant through the National Science Foundation,s Major Research ... is the principal investigator on this grant, which ...
... An important conference on the actions of Vitamin D ... London Medical School and the MRC Asthma UK Centre in ... for some time to be important for healthy bones, now ... of health including immune function, tuberculosis, asthma, diabetes, multiple sclerosis, ...
Cached Biology News:Queen's University professor's chemistry discovery may revolutionize cooking oil production 2New aid to biogeochemical research slated for materials characterization lab 2Conference to set the research agenda on Vitamin D in health and disease 2
(Date:11/24/2014)...  Last week, Representatives Gus Bilirakis ... a bold bipartisan step on behalf of patients ... Original co-sponsors of the legislation include Representatives McCaul ... drug makers and innovators to "repurpose" major market ... which opens the door to the development of ...
(Date:11/24/2014)... (PRWEB) November 23, 2014 One of the ... of optics and photonics is now available to high school ... low cost. SPIE, the international society for optics and ... the complete SPIE Digital Library available to high ... , “Light-based technologies are integral to all areas of life ...
(Date:11/24/2014)... 24, 2014  Spherix Incorporated (Nasdaq: ... the fostering and monetization of intellectual property, today ... Ltd.,  Case No. 3:13-cv-03494-M and  Spherix v. Uniden ... in the United States District Court for the ... On November 21, 2014 the ...
(Date:11/22/2014)... (PRWEB) November 21, 2014 During his ... understood the need to surround himself with great people ... and entrepreneur, his friends often marveled at his extraordinarily ... lived his life and -- even with his death ... the Alzheimer’s disease that would ultimately take his life. ...
Breaking Biology Technology:OPEN Act Introduced to Repurpose Drugs for Rare Diseases 2SPIE Digital Library Now Available to High Schools, Two-Year Colleges at No or Low Cost 2Markman Hearing Held as Scheduled in VTech and Uniden Cases 2Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 2Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 3
... Ky. and RALEIGH, N.C., April 28 ... provider of healthcare on-demand patient and staff education, healthcare ... with Baptist Hospital East, in Louisville, KY. The facility ... in the fall of 2008 and chose TeleHealth Services ...
... Techne Corporation (Nasdaq: TECH ) announced that its ... $0.25 per share for the quarter ended March 31, 2009. ... to all common shareholders of record on May 8, 2009. ... of Directors on a quarterly basis.Techne,s Board of Directors also ...
... will provide human safety and, pharmacodynamic ... to announce that its novel Innate Defense Regulator (IDR) ... time on April 27, 2009. The healthy volunteers were ... being performed for Inimex in Montreal with the approval ...
Cached Biology Technology:TeleHealth Services Chosen by Baptist Hospital East in Development of New Park Tower 2TeleHealth Services Chosen by Baptist Hospital East in Development of New Park Tower 3Techne Corporation Declares Dividend and Announces an Increase in Its Share Repurchase Program 2Inimex Pharmaceuticals begins First Clinical Study of an Innate Defense Regulator 2
... Mynox is the first biological ... killing them, and not just ... the only anti-mycoplasma agent that ... virus stocks directly. The cytotoxicity ...
... Acridinium NHS ester can ... and nucleic acids. The covalently ... produce chemiluminescence in the presence ... ester-labeled proteins can be used ...
... assay (EMSA) is a powerful tool for ... gel shift or gel retardation, the assay ... subjected to electrophoresis, free DNA will migrate ... LightShift Chemiluminescent EMSA Kit is a nonradioactive ...
... Cytomics FC 500 Series is ... with the most advanced technologies ... delivers flexible testing, powerful software ... that help researchers optimize their ...
Biology Products: