Navigation Links
Pair of cancer genes found to drive both cell migration and division

he other side. But when both enzymes are missing, levels of PIP3 remain constant throughout the membrane, and the cell can't migrate properly.

In experiments with single-celled amoebae, Devreotes and his team learned that PTEN and PI3K do the same thing to PIP3 in dividing cells. When a normal cell prepares to divide, it first doubles its genetic material, and then creates a "furrow" down the middle, cutting the cell in half. The research team noticed that the two halves of a normal dividing cell looked and acted like two cells moving away from each other.

"Essentially, the two halves are like migrating cells - PIP3 levels are high on the sides that represent the 'fronts' of what will be two new cells, and they are low at the furrow, or what amounts to the back of the new cells," says Devreotes.

In their experiments, cells without PTEN and PI3K couldn't regulate levels of PIP3, and they divided much slower than normal cells. These cells became "stuck" and accumulated many copies of their genetic material because they could do everything required for cell division except complete the split, the researchers found.

"There are ways the cell can make PIP3 even when PI3K is missing, but the major way to break it down is by using PTEN. So if PTEN isn't there to destroy PIP3 at the furrow, the halves can't pull apart," says Chris Janetopoulos, Ph.D., a research associate in Devreotes's lab and first author on the paper. The cells' problems were eliminated when the researchers added the human PTEN gene to the mutated amoebae. Like the amoeba's own PTEN, the human version cleaned up PIP3, restoring its normal distribution within the cell. This indicates that human cells likely use the new mechanism to divide as well.

The next steps are to study the roles of the two genes in dividing cells by seeing if controlling the location of the PTEN and PI3K proteins can determine the direction in which cells divide, Devreotes says.


'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2

Related biology news :

1. Viral DNA sequence a possible trigger for breast cancer
2. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
3. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
4. Columbia research lifts major hurdle to gene therapy for cancer
5. Combination therapy boosts effectiveness of telomere-directed cancer cell death
6. Mitochondrial DNA mutations play significant role in prostate cancer
7. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
8. BRCA1 causes ovarian cancer through indirect, biochemical route
9. Researchers identify target for cancer drugs
10. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
11. First atlas of key brain genes could speed research on cancer, neurological diseases
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Pair cancer genes found drive both cell migration and division

(Date:11/4/2014)... Medicine announced today that it is a Grand ... Bill & Melinda Gates Foundation. Laura Goetzl, ... Sciences; and Vice Chair of Research and Academic ... pursue an innovative global health and development research ... Neurodevelopment.", Grand Challenges Explorations (GCE) funds individuals worldwide ...
(Date:11/4/2014)... , November 4, 2014   ... market growth   Fuel3D , a developer ... a funding round totaling $6.4 million (£4 million). This funding ... secured earlier this year and paves the way for the ... The funding round was led by Chimera Partners ...
(Date:11/3/2014)... -- Research and Markets has announced the addition ... and Companies" to their offering. This ... have already started to play an important role in the ... old fashioned bone marrow transplants. Role of cells in drug ... a part of medical practice. Stem cells are ...
Breaking Biology News(10 mins):Temple University School of Medicine receives Grand Challenges Explorations grant 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3
... likely impact of ocean acidification on shellfish and other marine ... is published this week (date) in the journal Global ... because some of the increased carbon dioxide humans are adding ... water to produce an acid. The results suggest that ...
... by the National Science Foundation (NSF) found state agency ... fiscal year 2009, a 7 percent increase over the ... details nationwide and state-by-state totals of R&D activities performed ... first time survey data are available by individual state ...
... release is available in German . Tomato ... with a genetic defect that made the fruits mature very slowly, ... were delighted as it gave them more time to transport the ... it would be sold. At the stores, the tomatoes could then ...
Cached Biology News:New study helps predict impact of ocean acidification on shellfish 2New study helps predict impact of ocean acidification on shellfish 3Ethylene of no effect -- why peppers do not mature after picking 2
(Date:11/22/2014)... 21, 2014 RURO, Inc., a ... has released Limfinity® version 5.1.4. , RURO’s deployment ... Limfinity® than ever in RURO’s 8 year history. ... framework enhancement. Limfinity® version 5.1.4 is the perfect ... beyond bug fixes! , Limfinity® 5.1.4 release highlights ...
(Date:11/22/2014)... November 21, 2014   ... Chief Commercial Officer zu KLOX    ... und Chief Financial Officer bestellt    ... Vermarktung seines jüngst zugelassenen Behandlungssystems zur Wundheilung zu beginnen ... das "Unternehmen") ist sehr erfreut, die folgenden personellen Veränderungen ...
(Date:11/21/2014)... 2014 Author Matthew J. Pallamary’s second ... Other Side” published as a tribute to his ... “Fiction: Short Story” category of the 2014 USA ... CEO of USA Book News, said this year’s contest ... including Simon & Schuster, Penguin, John Wiley & Sons, ...
(Date:11/21/2014)... Why did Stephen Hawking become so ... instantly recognizable? Why have they become icons to rival ... Hilton Ratcliffe seeks out the answers to those questions, ... do with science. In " Stephen Hawking Smoked My ... 2014), Ratcliffe puts it plainly: , “It is ...
Breaking Biology Technology:RURO Announces Limfinity® version 5.1.4 2KLOX Technologies meldet Neubesetzung von Führungspositionen 2KLOX Technologies meldet Neubesetzung von Führungspositionen 3KLOX Technologies meldet Neubesetzung von Führungspositionen 4KLOX Technologies meldet Neubesetzung von Führungspositionen 5Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 2Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 4“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 2“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 4
... 8, 2011 -- The Maryland Technology Enterprise Institute (Mtech) ... University of Maryland $75K Business Plan Competition . ... as a launch pad for Inc. 500 ... in the categories of high-technology and biotechnology and undergraduate ...
... 2011 The National Foundation for Cancer Research (NFCR) announced ... Annual Szent-G y o rgyi ... Professor and Jack Schultz Chair in Basic Science at the ... for her discoveries of the relationship between development and cancer, ...
... at the Institute for Genome Sciences at the University ... FBI, the U.S. Army Medical Research Institute of Infectious ... scientific paper based on their investigation into the anthrax ... use of genomics and microbiology in a criminal investigation. ...
Cached Biology Technology:Mtech Announces Semifinalists for University of Maryland $75K Business Plan Competition 2Mtech Announces Semifinalists for University of Maryland $75K Business Plan Competition 3Mtech Announces Semifinalists for University of Maryland $75K Business Plan Competition 4Mtech Announces Semifinalists for University of Maryland $75K Business Plan Competition 5Mtech Announces Semifinalists for University of Maryland $75K Business Plan Competition 66th Annual Szent-Gyorgyi Prize for Progress in Cancer Research Awarded to Beatrice Mintz, Ph.D. 26th Annual Szent-Gyorgyi Prize for Progress in Cancer Research Awarded to Beatrice Mintz, Ph.D. 36th Annual Szent-Gyorgyi Prize for Progress in Cancer Research Awarded to Beatrice Mintz, Ph.D. 4University of Maryland School of Medicine publishes scientific paper on 2001 anthrax attacks 2University of Maryland School of Medicine publishes scientific paper on 2001 anthrax attacks 3University of Maryland School of Medicine publishes scientific paper on 2001 anthrax attacks 4
Buckets for 2 racks of 5 tubes, type Stago/Hitachi...
Rotor for four tube-loaded buckets; ma RCF 2550g; sold without buckets...
... up kit. Includes configured Laptop PC with ... 2 MultiBlock satellite thermal cyclers (non-robotic). ... friendly software. Store/track run data. ... Outstanding uniformity. Advanced control algorithms ...
... is a microprocessor controlled, high speed ... with exceptionally smooth operation make the ... involving fluorescence microscopy, ratio imaging, spectrophotometry, ... rapid and accurate aperture positioning. The ...
Biology Products: