Navigation Links
Pair of cancer genes found to drive both cell migration and division

Johns Hopkins researchers have found that two genes already known to control cell movement are also needed for proper cell division. They report their findings in the April issue of Developmental Cell.

The researchers discovered that the two genes are required for a dividing cell's halves to separate, raising the possibility that interfering with them could be helpful in stopping the uncontrolled cell division found in cancers. Mutations in the genes, called PTEN and PI3K, already had been found in over half of all human cancers.

"In cancer, you sometimes see cells failing to divide or undergoing unequal divisions. In addition, cell migration can lead to tumors spreading and developing in different places in the body," says Peter Devreotes, Ph.D., professor and director of Cell Biology at the Johns Hopkins School of Medicine's Institute for Basic Biomedical Sciences. "Now that we know that PTEN and PI3K are involved in both of these processes, it should stimulate new avenues of research in cancer."

Medicines that target PI3K or PTEN and prevent cell migration could also potentially help with inflammatory disorders, such as arthritis, since inflammation is caused when lots of immune cells move to one part of the body and cause it to swell painfully, he says.

The researchers also hope their findings will provide a bridge between two scientific fields that have traditionally kept to themselves.

"Scientists studying cell migration have focused on the front of the cell and what drives it, while cell division researchers have concentrated on the furrow within the dividing cell," says Devreotes. "But we've found that when you look at the whole cell, there are a lot of similarities between division and movement."

In normal cells, the two genes work in tandem to regulate a molecule called PIP3, which helps the cell decide where to push outward - PI3K makes PIP3 on the membrane on one side of a cell while PTEN breaks it down on t he other side. But when both enzymes are missing, levels of PIP3 remain constant throughout the membrane, and the cell can't migrate properly.

In experiments with single-celled amoebae, Devreotes and his team learned that PTEN and PI3K do the same thing to PIP3 in dividing cells. When a normal cell prepares to divide, it first doubles its genetic material, and then creates a "furrow" down the middle, cutting the cell in half. The research team noticed that the two halves of a normal dividing cell looked and acted like two cells moving away from each other.

"Essentially, the two halves are like migrating cells - PIP3 levels are high on the sides that represent the 'fronts' of what will be two new cells, and they are low at the furrow, or what amounts to the back of the new cells," says Devreotes.

In their experiments, cells without PTEN and PI3K couldn't regulate levels of PIP3, and they divided much slower than normal cells. These cells became "stuck" and accumulated many copies of their genetic material because they could do everything required for cell division except complete the split, the researchers found.

"There are ways the cell can make PIP3 even when PI3K is missing, but the major way to break it down is by using PTEN. So if PTEN isn't there to destroy PIP3 at the furrow, the halves can't pull apart," says Chris Janetopoulos, Ph.D., a research associate in Devreotes's lab and first author on the paper. The cells' problems were eliminated when the researchers added the human PTEN gene to the mutated amoebae. Like the amoeba's own PTEN, the human version cleaned up PIP3, restoring its normal distribution within the cell. This indicates that human cells likely use the new mechanism to divide as well.

The next steps are to study the roles of the two genes in dividing cells by seeing if controlling the location of the PTEN and PI3K proteins can determine the direction in which cells divide, Devreotes says.


'"/>

Source:Johns Hopkins Medical Institutions


Related biology news :

1. Viral DNA sequence a possible trigger for breast cancer
2. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
3. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
4. Columbia research lifts major hurdle to gene therapy for cancer
5. Combination therapy boosts effectiveness of telomere-directed cancer cell death
6. Mitochondrial DNA mutations play significant role in prostate cancer
7. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
8. BRCA1 causes ovarian cancer through indirect, biochemical route
9. Researchers identify target for cancer drugs
10. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
11. First atlas of key brain genes could speed research on cancer, neurological diseases
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/1/2016)... , February 1, 2016 ... advancements to drive global touchfree intuitive gesture control market ... --> Rising sales of consumer electronics coupled with ... control market size through 2020 ... electronics coupled with new technological advancements to drive global ...
(Date:1/27/2016)... , Jan. 27, 2016  Rite Track, Inc. ... in West Chester, Ohio announced ... winning service staff, based in Austin, Texas ... and ability to provide modifications, installations and technical support ... , CEO of PLUS, commented, "PLUS has provided world ...
(Date:1/22/2016)... http://www.researchandmarkets.com/research/p74whf/global_biometrics ) ... "Global Biometrics Market in Retail Sector 2016-2020" ... --> http://www.researchandmarkets.com/research/p74whf/global_biometrics ) has announced the ... in Retail Sector 2016-2020" report to ... and Markets ( http://www.researchandmarkets.com/research/p74whf/global_biometrics ) has announced ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... 11, 2016   BioInformant announces the February ... Research Products, Opportunities, Tools, and Technologies – Market Size, ... The first and ... cell industry, BioInformant has more than a decade of ... market, by stem cell type. This powerful 175 page ...
(Date:2/10/2016)... WASHINGTON , February 10, 2016 Early-career ... , Peru , Uganda ... their life-enhancing work in health and nutrition   Indonesia ... Uganda and Yemen are ... sciences and epidemiology. They are also celebrated for mentoring young women scientists ...
(Date:2/10/2016)... Feb. 10, 2016  IsoRay, Inc. (NYSE MKT: ISR), ... and medical radioisotope applications for the treatment of prostate, ... announced its financial results for the second quarter and ... 2015. --> --> ... of fiscal 2016, which ended December 31, 2015, a ...
(Date:2/10/2016)... ... February 10, 2016 , ... LATHAM, NEW YORK... ... SPIE Photonics West conference in San Francisco’s Moscone Center from February 16-18, ... same venue. , These latest InGaAs PIN diode standard packages feature a TO-46 ...
Breaking Biology Technology: