Navigation Links
Pair of cancer genes found to drive both cell migration and division

Johns Hopkins researchers have found that two genes already known to control cell movement are also needed for proper cell division. They report their findings in the April issue of Developmental Cell.

The researchers discovered that the two genes are required for a dividing cell's halves to separate, raising the possibility that interfering with them could be helpful in stopping the uncontrolled cell division found in cancers. Mutations in the genes, called PTEN and PI3K, already had been found in over half of all human cancers.

"In cancer, you sometimes see cells failing to divide or undergoing unequal divisions. In addition, cell migration can lead to tumors spreading and developing in different places in the body," says Peter Devreotes, Ph.D., professor and director of Cell Biology at the Johns Hopkins School of Medicine's Institute for Basic Biomedical Sciences. "Now that we know that PTEN and PI3K are involved in both of these processes, it should stimulate new avenues of research in cancer."

Medicines that target PI3K or PTEN and prevent cell migration could also potentially help with inflammatory disorders, such as arthritis, since inflammation is caused when lots of immune cells move to one part of the body and cause it to swell painfully, he says.

The researchers also hope their findings will provide a bridge between two scientific fields that have traditionally kept to themselves.

"Scientists studying cell migration have focused on the front of the cell and what drives it, while cell division researchers have concentrated on the furrow within the dividing cell," says Devreotes. "But we've found that when you look at the whole cell, there are a lot of similarities between division and movement."

In normal cells, the two genes work in tandem to regulate a molecule called PIP3, which helps the cell decide where to push outward - PI3K makes PIP3 on the membrane on one side of a cell while PTEN breaks it down on t
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2

Related biology news :

1. Viral DNA sequence a possible trigger for breast cancer
2. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
3. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
4. Columbia research lifts major hurdle to gene therapy for cancer
5. Combination therapy boosts effectiveness of telomere-directed cancer cell death
6. Mitochondrial DNA mutations play significant role in prostate cancer
7. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
8. BRCA1 causes ovarian cancer through indirect, biochemical route
9. Researchers identify target for cancer drugs
10. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
11. First atlas of key brain genes could speed research on cancer, neurological diseases

Post Your Comments:
(Date:11/25/2009)...assistant professors recently received funding fro...e research beneficial to understanding the environ...pher Blackwood, assistant professor in the Departm...support two separate research projects. , His fi...Communities and Functions from the Leaf to the Lan...
(Date:11/24/2009)...new doors to understanding how sounds associated w...e mammal or if they hear it at all. , The same ... NASA uses to detect flaws in the space shuttle,s ...ists to peek inside the giant head of a whale. The...plicas of a whale,s hearing anatomy using a breakt...
(Date:11/24/2009)...College of Medical Toxicology (ACMT) have signed a...he Journal of Medical Toxicology (JMT), the offi... It was previously published by the University of...Toxicology , an international, peer-reviewed journ...tice of medical toxicology. The quarterly journal...
Breaking Biology News(10 mins):Kent State University professors focus research on the environment with grants totaling $890,000 2Rocket science leads to new whale discovery 2Springer and the American College of Medical Toxicology to work together 2PETAs push for changes in USDA testing pays off for animals 10415 1CDPHP Launches National Network and Three In One Plan and Expands Member Incentives 59754 1CDPHP Launches National Network and Three In One Plan and Expands Member Incentives 59754 2CDPHP Launches National Network and Three In One Plan and Expands Member Incentives 59754 3CDPHP Launches National Network and Three In One Plan and Expands Member Incentives 59754 4CEL SCI Presents Data at American College of Rheumatology Conference Which Suggests that CEL 2000 Has Potential to Slow Damage Caused by Rheumatoid Ar 59750 1CEL SCI Presents Data at American College of Rheumatology Conference Which Suggests that CEL 2000 Has Potential to Slow Damage Caused by Rheumatoid Ar 59750 2CEL SCI Presents Data at American College of Rheumatology Conference Which Suggests that CEL 2000 Has Potential to Slow Damage Caused by Rheumatoid Ar 59750 3CEL SCI Presents Data at American College of Rheumatology Conference Which Suggests that CEL 2000 Has Potential to Slow Damage Caused by Rheumatoid Ar 59750 4
... across which information crosses between nerve ce...ns, called plasticity, play a vital role in both m...ow nerve signals propagate. , Assistant profess...ab that studies learning and memory in fruit flies...d a group of fly genes needed for memory formation...
...ark populations worldwide are declining from destr...a rising global demand for shark products (mainly ...ly depleted and only a few stable or recovering, a...shark experts from the Pew Institute for Ocean Sci...ckwell Publishing, and being released today.* , ...
..., 2008 -Sustaining hope in the face of a chronic, ...clerosis (ALS) should be a goal of palliative care... from focusing on the self to concern for others, ...ue (Volume 8, Number 3) of Journal of Palliative M...d publication of Mary Ann Liebert, Inc ( www.liebe...
Other Biology News:CSHL scientists identify a mechanism that helps fruit flies lock-in memories 2Oceanic sharks worldwide at serious risk from high-seas fishing, rising demand for shark products 2Oceanic sharks worldwide at serious risk from high-seas fishing, rising demand for shark products 3Oceanic sharks worldwide at serious risk from high-seas fishing, rising demand for shark products 4Hope among patients with ALS may take a variety of forms 2
(Date:11/24/2009)...ewswire/--Twomoreprestigiousuniversitieshavejoined...dcareerssiteforlifescienceprofessionals. ,, Nor...bboard,joining28othermajorlifesciencetrainingInsti...m ,isonlyforpost-graduatesinthelifesciences.Whilet...et,BioCareerCenteristheonlyonethatserveslifescienc...
(Date:11/24/2009)...4/PRNewswire-FirstCall/--deCODE,genetics,Inc.(Nasd...stday"motionsbytheU.S.BankruptcyCourtfortheDistric...iledavoluntarypetitionfor,reliefunderChapter11ofth.... , TheordersissuedbytheBankruptcyCourtallowt...hapter11proceedings.Inparticular,the,companyreceiv...
(Date:11/24/2009)...ecently approved the Promega PowerPlex 16 HS Syste...rating DNA records for the National DNA Index Syst...WEB) -- The FBI recently approved the Promega Pow...participating in, or generating DNA records for, t...y contains more than seven million profiles and ha...
(Date:11/24/2009)...RNewswire-FirstCall/--GenomicHealth,Inc.(Nasdaq: G...xecutiveChairman,willpresentatthe21stAnnualPiperJa...cember1,2009at10:00a.m.ET. ,, Toaccessthelivean...ttheInvestorRelationssectionofGenomicHealth,swebsi...ecttothewebsiteatleast15minutespriortothebeginning...
Breaking Biology Technology:Two Major Universities Join Nation's Leading Postgrad Bio Job Board 2deCODE genetics, Inc. Announces Approval of First Day Motions by Bankruptcy Court 2deCODE genetics, Inc. Announces Approval of First Day Motions by Bankruptcy Court 3NDIS Approval of Promega PowerPlex Kit Clears Path for More DNA Profiles to be Added to U.S. Database 2Genomic Health to Present at Piper Jaffray Health Care Conference 2
...h 13 ,Cellectis SA (NYSE: ALCLS ), a world leader...y that it filed a patent infringement lawsuit agai...es District Court for the,Eastern District of Nort...y making and selling certain meganucleases, Precis...lating to its proprietary meganuclease,recombinati...
.../ - Angiotech Pharmaceuticals,Inc. (NASDAQ: ANPI ...,medical device company, today announced the filin... and Management,s Discussion and Analysis,for the ...f its audited,consolidated financial statements fo... ended December 31, 2007, the Company,s net loss a...
...c.,(Nasdaq: BNVI ) announced today the appointmen...of Directors. Dr. Butler has extensive regulatory,...es, and in particular in,advancing cancer drug dev...d to have George on board as we move into a new,ph...linical trial,programs," said Isaac Cohen, O.M.D.,...
Other Biology Technology:Cellectis Sues Precision BioSciences for Infringement of its Patents Concerning Meganuclease Technology 2Cellectis Sues Precision BioSciences for Infringement of its Patents Concerning Meganuclease Technology 3Cellectis Sues Precision BioSciences for Infringement of its Patents Concerning Meganuclease Technology 4Angiotech announces filing of audited financial results for the year ended December 31, 2007 and restatement of results for the year ended December 31, 2006 2Angiotech announces filing of audited financial results for the year ended December 31, 2007 and restatement of results for the year ended December 31, 2006 3Angiotech announces filing of audited financial results for the year ended December 31, 2007 and restatement of results for the year ended December 31, 2006 4Angiotech announces filing of audited financial results for the year ended December 31, 2007 and restatement of results for the year ended December 31, 2006 5Angiotech announces filing of audited financial results for the year ended December 31, 2007 and restatement of results for the year ended December 31, 2006 6Angiotech announces filing of audited financial results for the year ended December 31, 2007 and restatement of results for the year ended December 31, 2006 7Angiotech announces filing of audited financial results for the year ended December 31, 2007 and restatement of results for the year ended December 31, 2006 8Angiotech announces filing of audited financial results for the year ended December 31, 2007 and restatement of results for the year ended December 31, 2006 9George Butler Joins Bionovo's Board of Directors 2George Butler Joins Bionovo's Board of Directors 3
Rabbit Anti-Rat Heme Oxygenase-1 (2-23) Polyclonal Antibody, Unconjugated from Calbiochem
Vitality pIRES-hrGFP-1 Vector from Stratagene
1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine-N- [Carboxy(Polyethylene Glycol)2000] Ammonium Salt from Avanti Polar Lipids Inc.
HyQ SFX-Insect MP (1 x 5 L powder) from Hyclone
Biology Products: