Navigation Links
Pain killer fights breast cancer by targeting key enzyme

ogram, on March 27 in Atlanta at the annual meeting of the American Chemical Society.

By altering the drug's basic chemical structure, the researchers could create several variations, or analogs, of nimesulide. Nimesulide has been around since 1985, but was banned from clinical and over-the-counter use in the United States due to rare cases of liver damage and related deaths.

"We are working on analogs that will be selective for aromatase expression and also have diminished side effects," Brueggemeier said. "We are obviously in the very early stages of drug discovery with nimesulide analogs, and a long path of preclinical research is needed before we can even begin to think about potential drugs."

The researchers took several of these nimesulide analogs and, in laboratory cultures, tested their effects on estrogen-dependent breast cancer cells taken from human breast tissue. They also tested the analogs on human placental cells to see if the analogs would stop aromatase production in these cells.

The nimesulide analogs stopped aromatase production in the breast cells, but not in the placental cells.

"Aromatase is necessary for normal functions of many tissues in the body," Brueggemeier said. "We still have to test these analogs in other kinds of tissues, however, before we are completely sure that the nimesulide analogs' effects are specific to breast cancer cells."

The analogs prevented a crucial step in the aromatase production process in the breast cancer cells ?they stopped transcription, the first step in gene expression. Compared to other tissues, breast cancer cells use a slightly different signal to indicate when it is time to make more aromatase.

"The pathway leading the aromatase production in breast cancer cells seems to be unique to these diseased cells," Brueggemeier said. "It suggests that aromatase production in other tissues that rely on the enzyme could be spared if a nimesulide analog was take
'"/>

Source:Ohio State University


Page: 1 2 3

Related biology news :

1. Genetically modified natural killer immune cells attack, kill leukemia cells
2. Thinking the pain away? Study shows the brains painkillers may cause placebo effect
3. Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack
4. Can two killers make a cure?
5. Secret sex life of killer fungus?
6. Brazilians sequence genes of pig and poultry killers
7. Russian surrogate alcohols are a killer
8. Newly discovered killer cell fights cancer
9. How HIV exhausts killer T cells
10. Three-in-one virus killer prevents common, often fatal infections
11. Hope for major advance in fighting world killer disease
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Pain killer fights breast cancer targeting key enzyme

(Date:12/17/2014)... 2014  HITLAB SM announced today its ... to confirm its adherence to current U.S. Food ... HITLAB to conduct regulated smart device and smart ... patient safety and research quality. "HITLAB ... and delivery with innovative technology," said Laura ...
(Date:12/15/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ) ... Facial Recognition Market 2015-2019" report to their ... Facial recognition is a technology used ... measures the overall facial feature of a person ... distance between eyes. Facial recognition is used for ...
(Date:12/11/2014)... 10, 2014  Data Sciences International (DSI), the ... a new series of digital telemetry implants to ... M series, part of the PhysioTel™ Digital platform, ... possible physiologic data when incorporating functional endpoints into ... to toxicology studies has evolved from short ECG ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3New telemetry implants expected to change how large animal toxicology studies are conducted 2
... -- Yoho National Park,s 505-million-year-old Burgess Shale home ... very primitive human relative is one of the ... century after its discovery, a compelling sequel has been ... new Burgess Shale fossil site has been located that ...
... cancer, also kills a fungus that causes a deadly brain ... to new treatments for a disease that kills more HIV/AIDS ... open-access journal of the American Society for Microbiology (ASM.) ... see if tamoxifen can be used as a drug in ...
... The Translational Genomics Research Institute (TGen) has uncovered possible ... according to a first-of-its-kind study published in the scientific journal ... uncovered by TGen now can be used to identify potential ... estimated 45,000 patients in the U.S. each year whose cancer ...
Cached Biology News:Researchers discover 'epic' new Burgess Shale site in Canada's Kootenay National Park 2Breast cancer drug fights fungal disease 2TGen study uncovers possible genetic markers in breast cancer that spreads to the brain 2
(Date:12/19/2014)... iLab Solutions, the global leader in core facility ... the new Director of Institutional Implementations and Sarah Becker ... new leadership positions were created to support iLab’s mission ... continues to meet the needs of its growing customer ... been deployed at over 450 core facilities across more ...
(Date:12/19/2014)... CA (PRWEB) December 18, 2014 With ... limited time special on Sartorius Biohit products . ... on mLINE pipettes, Picus Electronic Pipette Trade-in Program, and ... Health and Safety officers around the world. They are ... pipetting. Other features include:, ,     Full volume ...
(Date:12/19/2014)... , Dec. 18, 2014   ISN ... & Safety Performance Indicators publication series. With ... of activity reported in 2013 within its online contractor ... and safety key performance indicator (KPI) statistics. ... Clients, U.S. publication is available in two ...
(Date:12/17/2014)... Based on the revenues gained from surgical ... dominated by four major players contributing to approximately ... include GE Healthcare (U.K.), Siemens AG (Germany), Philips ... Report Copy at http://www.marketsandmarkets.com/Market-Reports/surgical-imaging-market-210534462.html , The ... to its strong product portfolio, which includes its ...
Breaking Biology Technology:iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4
... ASSAYS, , , , , ... DATA , , HIGHER THROUGHPUT ... , Every major pharmaceutical company uses the,Molecular Devices FLIPR ... Calcium Assay Kit from Molecular,Devices provides the easiest way to ...
... Su, M.S., ... , , INTRODUCTION , ... Of thespectrophotometric methods available, UV absorbance measurement at 260 nm ... microplateformat. 1 However, A 260 measurements do not ...
... INTRODUCTION ... of a dissolution apparatus is necessary to produce accurate results ... comparison between batches and between laboratories. USP requirements for calibration ... Dissolution. 1 Each individual apparatus (i.e. spindle ...
Cached Biology Technology:FLIPR Calcium Assay Kit Datasheet 2FLIPR Calcium Assay Kit Datasheet 3DNA Quantitation in the LMax Microplate Luminometer (MaxLine Application Note #37) 2DNA Quantitation in the LMax Microplate Luminometer (MaxLine Application Note #37) 3DNA Quantitation in the LMax Microplate Luminometer (MaxLine Application Note #37) 4Using the SpectraMax Plus for USP Dissolution Calibration (MaxLine Application Note #27) 2Using the SpectraMax Plus for USP Dissolution Calibration (MaxLine Application Note #27) 3Using the SpectraMax Plus for USP Dissolution Calibration (MaxLine Application Note #27) 4Using the SpectraMax Plus for USP Dissolution Calibration (MaxLine Application Note #27) 5Using the SpectraMax Plus for USP Dissolution Calibration (MaxLine Application Note #27) 6Using the SpectraMax Plus for USP Dissolution Calibration (MaxLine Application Note #27) 7Using the SpectraMax Plus for USP Dissolution Calibration (MaxLine Application Note #27) 8Using the SpectraMax Plus for USP Dissolution Calibration (MaxLine Application Note #27) 9
... Immunogen: Synthetic Peptide: M(1) E F ... G P P T M D L E(19) ... mouse cells.,PA1-072 has been successfully used in Western ... detects an ~86 kDa protein representing Mint3 from ...
... 3.5 is a user-friendly statistical software package ... to perform statistical analysis without being a ... your data and research and SigmaStat suggests ... against the tests underlying assumptions and suggests ...
... a chemiluminescent signal enhancing reagent that ... the signal obtained with all ECL ... Plus is derived from a powerful, ... or chemiluminescent substrate enhancers, ChemiLucent™ Plus ...
... Control at its Best: DASGIPs Process ... Online Changes & comprehensive documentation for ... parameters auch as pH, dissolved oxygen, ... and changeable online. Profiles, e.g. constant ...
Biology Products: