Navigation Links
Pain killer fights breast cancer by targeting key enzyme

ogram, on March 27 in Atlanta at the annual meeting of the American Chemical Society.

By altering the drug's basic chemical structure, the researchers could create several variations, or analogs, of nimesulide. Nimesulide has been around since 1985, but was banned from clinical and over-the-counter use in the United States due to rare cases of liver damage and related deaths.

"We are working on analogs that will be selective for aromatase expression and also have diminished side effects," Brueggemeier said. "We are obviously in the very early stages of drug discovery with nimesulide analogs, and a long path of preclinical research is needed before we can even begin to think about potential drugs."

The researchers took several of these nimesulide analogs and, in laboratory cultures, tested their effects on estrogen-dependent breast cancer cells taken from human breast tissue. They also tested the analogs on human placental cells to see if the analogs would stop aromatase production in these cells.

The nimesulide analogs stopped aromatase production in the breast cells, but not in the placental cells.

"Aromatase is necessary for normal functions of many tissues in the body," Brueggemeier said. "We still have to test these analogs in other kinds of tissues, however, before we are completely sure that the nimesulide analogs' effects are specific to breast cancer cells."

The analogs prevented a crucial step in the aromatase production process in the breast cancer cells ?they stopped transcription, the first step in gene expression. Compared to other tissues, breast cancer cells use a slightly different signal to indicate when it is time to make more aromatase.

"The pathway leading the aromatase production in breast cancer cells seems to be unique to these diseased cells," Brueggemeier said. "It suggests that aromatase production in other tissues that rely on the enzyme could be spared if a nimesulide analog was take
'"/>

Source:Ohio State University


Page: 1 2 3

Related biology news :

1. Genetically modified natural killer immune cells attack, kill leukemia cells
2. Thinking the pain away? Study shows the brains painkillers may cause placebo effect
3. Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack
4. Can two killers make a cure?
5. Secret sex life of killer fungus?
6. Brazilians sequence genes of pig and poultry killers
7. Russian surrogate alcohols are a killer
8. Newly discovered killer cell fights cancer
9. How HIV exhausts killer T cells
10. Three-in-one virus killer prevents common, often fatal infections
11. Hope for major advance in fighting world killer disease
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Pain killer fights breast cancer targeting key enzyme

(Date:8/1/2014)... enormous opportunities for both biological and future clinical ... cells in the body, offering immense hope of ... kidney, liver and lung diseases and making damaged ... Prof. Jinhui Chen from Indiana University in USA ... myriad biological, ethical, legal, political, and financial challenges. ...
(Date:8/1/2014)... of phloem, the conductive tissue through which plants transport ... cylindrical cells are capped at one end by a ... which in turn form a network throughout a plant,s ... cells which play an important role in carbon sequestration, ... their differentiation," says Professor Yk Helariutta from the Institute ...
(Date:8/1/2014)... August 1, 2014 The Journal of Nutrition Education ... Best Great Educational Material (GEM) awards, which were presented ... annual conference, "Nutrition Education Impact: Local to Global," in ... These annual awards recognize the authors of the best ... as judged by members of the JNEB Journal Committee ...
Breaking Biology News(10 mins):Developmental regulation of important plant phloem components discovered 2
... first time, scientists at King,s College London have identified a ... brain to intelligence. The study is published today in ... behind some forms of intellectual impairment. The researchers ... human brain. It is known as ,grey matter, and plays ...
... , , , , , ... , , AUDIO: ... significantly... , Click here for more information. , ... , , , , , ...
... century, plants and animals will need to adapt or shift ... an innovative global map of where species are likely to ... The findings appear in the science journal Nature . ... Center for Ecological Analysis and Synthesis (NCEAS) working group, 18 ...
Cached Biology News:Scientists identify gene linking brain structure to intelligence 2Manga comics may help promote fruit consumption among youth 2Manga comics may help promote fruit consumption among youth 3Maps show expected redistribution of global species due to climate change 2Maps show expected redistribution of global species due to climate change 3
(Date:8/1/2014)... 2014 According to a new ... - Global Industry Analysis, Size, Share, Growth, Trends and ... USD 25.16 billion in 2013, which is expected to ... CAGR of 10.4% from 2014 to 2020. ... Increasing demand for accurate early diagnosis and ...
(Date:8/1/2014)... Once a decision has been made to increase ... how to define your tolerance for lowest cost design ... Director of Facilities Integration at Fluor Industrial Services, Craig ... and special guest Carrier Li, Director in Global Asset ... provide an examination of the Conceptual Design process and ...
(Date:8/1/2014)... 2014 Cambrex Corporation (NYSE: CBM ) ... Highlights , Second quarter sales ... same period last year. , Second quarter EBITDA increased ... same period last year (see table at the end of ... excluding the impact of foreign currency, to between 13% and ...
(Date:8/1/2014)... Testing the mechanical properties of ... understanding embryonic development. How and why embryonic ... functionally distinct tissues is important because abnormalities can ... McDevitt, Melissa Kinney, and Rabbia Saeed worked from ... cues to control many aspects of embryo development. ...
Breaking Biology Technology:Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 2Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 3Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 4Defining Low Cost in Your Solution for Future Facilities, New Webinar for Pharma, Biotech, Medical Device and Healthcare Companies, Hosted by Xtalks 2Cambrex Reports Second Quarter 2014 Financial Results 2Cambrex Reports Second Quarter 2014 Financial Results 3Cambrex Reports Second Quarter 2014 Financial Results 4Cambrex Reports Second Quarter 2014 Financial Results 5Cambrex Reports Second Quarter 2014 Financial Results 6Cambrex Reports Second Quarter 2014 Financial Results 7Cambrex Reports Second Quarter 2014 Financial Results 8Cambrex Reports Second Quarter 2014 Financial Results 9Cambrex Reports Second Quarter 2014 Financial Results 10Cambrex Reports Second Quarter 2014 Financial Results 11Cambrex Reports Second Quarter 2014 Financial Results 12Cambrex Reports Second Quarter 2014 Financial Results 13Cambrex Reports Second Quarter 2014 Financial Results 14Cambrex Reports Second Quarter 2014 Financial Results 15Cambrex Reports Second Quarter 2014 Financial Results 16Study Links Biomechanics and Gene Expression in Stem Cells 2
... part of the,"SCIENCEsuisse" project, swissinfo.ch is presenting profiles ... disciplines. The focus is on,Switzerland,s high international reputation ... SSR idee suisse initiative, in collaboration with,the Swiss ... give readers an insight into what,scientists are studying ...
... Nov. 11 Accumetrics, Inc. has announced the,appointment of ... the company.,Dr. Young will serve in a part-time capacity ... and Director of the Cardiovascular,Innovations Program at The Ohio ... the main liaison to practicing clinicians, as well as,coordinating ...
... Potentia Pharmaceuticals, a,privately held biotechnology company developing ... announced today the appointments,of Johanna M. Seddon, M.D. ... Board effective November 6, 2008., Dr. Seddon ... pioneer,in nutritional and genetic research in age-related macular ...
Cached Biology Technology:25 Short Films About Top-Level Research on swissinfo.ch 2Accumetrics Appoints John J. Young, MD Chief Medical Officer 2Potentia Pharmaceuticals Appoints Johanna M. Seddon, M.D. and Janet Stoltz Sunness, M.D. to Scientific Advisory Board 2Potentia Pharmaceuticals Appoints Johanna M. Seddon, M.D. and Janet Stoltz Sunness, M.D. to Scientific Advisory Board 3
Anti-Goat HRP-DAB Cell & Tissue Staining Kit...
Anti-Goat HRP-AEC Cell & Tissue Staining Kit...
... provides all the materials necessary for the isolation ... antigen studies analysis. Kit Components: ... 5122) One bottle containing 220 mL of buffered ... (5X) - (Catalog No. 5113) One bottle containing ...
... CultureWell cell culture systems provide ... cultured cells for staining and ... silicone gaskets preassembled with standard ... plates. The entire system is ...
Biology Products: