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PNAS study reveals why organs fail following massive trauma

Along with Miller-Graziano, the University of Rochester Medical Center team is led by Paul E. Bankey, M.D., Ph.D., director of Trauma and Critical Care in the Department of Surgery, and includes Asit De, Ph.D., assistant professor of surgery, and Krzysztof Laudanski, M.D., a post-doctoral fellow. Fifteen authors from eight universities and one pharmaceutical company collaborated on the PNAS article, including the Stanford Human Genome Center.

The trauma glue grant was launched in 2001 with an original $30 million award over five years, and has just been renewed with an additional $30 million in funding. The University of Rochester Medical Center team will receive about $3.9 million for its role between the two periods of the grant.

"These findings strikingly reveal that novel interactions among signaling pathways can be deconstructed in hospitalized patient populations," Bankey said. "For the first time, we can uncover changes in cells that tell us which patients are recovering, and which are getting worse, in almost any disease that involves the immune system."


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Source:University of Rochester Medical Center


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