Navigation Links
PNAS study reveals why organs fail following massive trauma

ins that play a central role in T-cell mediated immune and organ failure. Given that severe trauma effects as many as 20 percent of the 20,000 or so human genes, finding the genes and proteins involved in T cell anergy and apoptosis amid this storm has been a challenge.

Researchers took blood samples from 22 healthy subjects, and from 18 consenting patients who had experienced severe trauma, and were in the midst of organ failure. The team then used unique, clinically applicable techniques to separate out each immune cell type in the patients' blood into pure samples for study. Only when researchers compared pure samples of the same immune cell types (e.g. T cells to T cells) did meaningful patterns emerge. The authors achieved a statistically significant picture of the differences between traumatized and healthy patients for the first time, and despite skeptics that said it could not be done.

With pure samples in hand, researchers used microarray technology to generate a long list of genes that change when a person undergoes massive trauma. They then ran that list through a database of genetic information to see which of the genes changed by trauma were listed in the literature as having a role in T cell function. What emerged was a map of the likely functions of hundreds of genes and proteins related to T cell post-trauma dysfunction, and their likely partners in signaling pathways. The final step was to demonstrate that the proteins associated with those genes have an actual role in organ failure via real-world biochemical tests.

Results showed that the expression of nearly 5,700 genes related to T cell function is changed in cases of massive trauma, as are 2800 genes related to the function of macrophages, partnering immune cells necessary to T cell activation. Trauma had the most profound effect on just 338 of the genes, an at least two-fold change in their expression, the process by which the information they store is converted into
'"/>

Source:University of Rochester Medical Center


Page: 1 2 3 4 5

Related biology news :

1. Bioartificial kidney under study at MCG
2. W.M. Keck Foundation funds study of friendly microbes
3. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
4. Genome-wide mouse study yields link to human leukemia
5. Clam embryo study shows pollutant mixture adversely affects nerve cell development
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Same mutation aided evolution in many fish species, Stanford study finds
8. Sequencing of marine bacterium will help study of cell communication
9. Genetically modified rice in China benefits farmers health, study finds
10. A new study examines how shared pathogens affect host populations
11. NYU study reveals how brains immune system fights viral encephalitis
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: PNAS study reveals why organs fail following massive trauma

(Date:8/22/2014)... are strong antioxidants and can reduce free ... neurons against oxidative stress? Jianbo Zhao and ... Liaoning Medical University, China discovered that green ... inhibit neuronal apoptosis, indicating green tea polyphenols ... neurons under oxidative stress. The relevant study ...
(Date:8/21/2014)... Ga. An international team of scientists including researchers from ... Brassica napus commonly known as canolain the journal Science ... the plant, which is used widely in farming and industry. ... its native Europe, but the winter crop is increasingly cultivated ... its naturally low levels of saturated fat and rich supply ...
(Date:8/21/2014)... growing in near darkness use a previously unknown process ... research team led by a Penn State University scientist ... research aimed at improving plant growth, harvesting energy from ... occurring on Lake Erie and other lakes worldwide. A ... Science Express edition of the journal ...
Breaking Biology News(10 mins):Canola genome sequence reveals evolutionary 'love triangle' 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 3
... light on the causes of Parkinson,s disease, researchers report that ... mitochondria. A shutdown in fuel can have devastating effects on ... energy despite making up only 2 percent of body weight. ... FDA approved drugs early on may prevent or delay the ...
... CAMBRIDGE, Mass. -- By creating a better way to ... with MIT,s Picower Institute for Learning and Memory and the ... synapse formation. These studies could also help further understanding of ... and Fragile X syndrome. The study will appear in the ...
... their dosages may be standardized, but not every patient ... personal genetic characteristics of individuals and populations can explain ... not another, so medical researchers are adopting the new ... lab is leading the way. Dr. Noam ...
Cached Biology News:In Parkinson's disease, brain cells abandon mitochondria, researchers report 2In Parkinson's disease, brain cells abandon mitochondria, researchers report 3MIT researchers develop a better way to see molecules at work in living brain cells 2An X-ray for your genes 2
(Date:8/21/2014)... N.Y. , Aug. 21, 2014  BioSpecifics ... biopharmaceutical company developing first in class collagenase-based products ... or CCH) in the U.S. and XIAPEX ® ... significant results from a randomized, double-blind Phase 2a ... cellulite, or edematous fibrosclerotic panniculopathy. The results showed ...
(Date:8/21/2014)... Texas (PRWEB) August 21, 2014 ... Seaweed Fertilizer Industry” is a professional and ... market. The report provides basic Seaweed Fertilizer ... and industry chain structure as well as ... market analysis, including domestic market as well ...
(Date:8/21/2014)... Rochelle, N.Y. (PRWEB) August 21, 2014 ... is the first private college in the Mid-Hudson Region ... College will now begin accepting applications from qualified “high-technology” ... , “We are very pleased to have been selected ... support Governor Cuomo’s transformative initiative to stimulate economic development ...
(Date:8/21/2014)... , Aug. 21, 2014  China Cord Blood Corporation ... its plan to release financial results for the first ... 2014, after market close in the US.  ... 8:00 a.m. ET on Friday, August 29, 2014 to ... of the Company,s recent developments, followed by a question ...
Breaking Biology Technology:BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 4BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 5Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 2The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 3China Cord Blood Corporation to Report First Quarter of Fiscal 2015 Financial Results 2
... Inc., a medical device,company that has developed a ... announced today that they have successfully raised $1.4,million ... Chief,Executive Officer, Clark Adams stated, "Valor,s Board and ... will be used to complete,clinical trials needed for ...
... 6 Halozyme Therapeutics, Inc.,(Nasdaq: HALO ), ... extracellular matrix for the drug delivery,endocrinology, oncology, and ... and nine months ended September 30, 2008., ... and I am,pleased with the initiation of our ...
... 6 NutraCea (OTC Bulletin Board:,NTRZ), a world ... and,technology announced today that it has appointed Olga ... Todd Crow, in accordance with,his previously announced intentions, ... a consulting and advisory capacity., Ms. Hernandez-Longan ...
Cached Biology Technology:Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 2Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 3Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 4Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 5Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 6Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 7Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 8NutraCea Appoints New Chief Financial Officer 2
... Tissue Array (MSTA) slides were designed to study ... from multiple species. Tissue slices from three ... which can then be treated as a single ... in situ hybridization. This format allows ...
... Clear yellow solution. In ... thimerosal, and other proprietary ... Diluent formulated to stabilize ... antibody conjugates at high ...
... used to predict the melting ... up to 3,200 bases, which ... primers and GC clamps for ... gel electrophoresis (DGGE), constant denaturing ...
... Mini-Sub cell GT cell and PowerPac basic power ... of nucleic acids in agarose gels. The Mini-Sub ... with cables and electrodes, a 7 x 7 ... casting gates, and two 1.5 mm fixed-height combs ...
Biology Products: