Navigation Links
PNAS study reveals why organs fail following massive trauma

& Immunology at the University of Rochester Medical Center, and an author of the PNAS study. "Beyond trauma, we believe that the techniques established here can provide insights into many disease that involve human immune system failure."

No Respite from Toxins

The human immune system is actually two systems developed at different points in human evolution. White blood cells of the more primitive innate system, like neutrophils and macrophages, form the first line of defense against disease. They swarm to the injury to engulf and destroy bacteria with toxic molecules and biochemicals. Because these same molecules and chemicals are also toxic to nearby human cells, the innate response is normally shut down quickly by the onset of the more time-consuming, precise and thorough adaptive immune system.

This second system pumps out an endless variety of immune cells on the hope that one or more will be the right shape to link up with, and become activated by, any invader encountered. When one of those immune cells, called lymphocytes, recognizes a bacterium or virus presented by the innate system, that lymphocyte expands into army of clones specifically designed to attack the invader at hand. Unfortunately, lymphocytes too are capable of mistakenly destroying human cells. Thus, they have developed quality control mechanisms where they can choose to stop expanding into an army (anergy) or to commit suicide (apoptosis).

The PNAS study offers new evidence that an overwhelming wave of biochemical signals created by the innate response after massive trauma can mistakenly trigger anergy and apoptosis, especially in T cell lymphocytes, shutting down the adaptive response before it can begin. Without the normal transition, the innate system continues to pump out toxic chemicals (cytokines) and molecules (free radicals) that tear at organs until they fail.

The goal of the current study was to identify the few genes and prote
'"/>

Source:University of Rochester Medical Center


Page: 1 2 3 4 5

Related biology news :

1. Bioartificial kidney under study at MCG
2. W.M. Keck Foundation funds study of friendly microbes
3. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
4. Genome-wide mouse study yields link to human leukemia
5. Clam embryo study shows pollutant mixture adversely affects nerve cell development
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Same mutation aided evolution in many fish species, Stanford study finds
8. Sequencing of marine bacterium will help study of cell communication
9. Genetically modified rice in China benefits farmers health, study finds
10. A new study examines how shared pathogens affect host populations
11. NYU study reveals how brains immune system fights viral encephalitis
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: PNAS study reveals why organs fail following massive trauma

(Date:7/11/2014)... Researchers from Salk Institute for Biological Studies, BGI, ... the safety and reliability of the existing targeted ... method, TALEN-HDAdV, which could significantly increased gene-correction efficiency ... study published online in Cell Stell Cell ... cell-based gene therapy. , The combination of stem ...
(Date:7/11/2014)... 11, 2014 The increased risk of kidney injury ... resuscitation fluids reflects the mass of HES molecules, according ... official journal of the International Anesthesia Research Society (IARS). ... harmful effect of HES on cultured human renal proximal ... Christian Wunder and colleagues of University Hospital Wrzburg, Austria. ...
(Date:7/11/2014)... , July 11, 2014 Research ... "International Biometrics Technology Market - Industry Analysis Size ... to their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... and crimes has created a need for high level ... used for personnel authentication such as username and passwords, ...
Breaking Biology News(10 mins):A new genome editing method brings the possibility of gene therapies closer to reality 2In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2
... When students using the Ask a Biologist Web site ask ... actually accessing the combined knowledge of more than 150 volunteer ... "That,s why Dr. Biology is so amazing," says Charles Kazilek, ... on the planet." Kazilek,s site, which attracts 3,000-4,000 visitors ...
... for the Advancement of Science has chosen Arizona State ... science education, to receive the Science Prize ... The prize, established to "encourage innovation and excellence in ... resources by students, teachers, and the public," recognizes the ...
... fish species in the ocean, but the majestic gliding ... astonishing feat of mathematics and energy conservation. In new ... Functional Ecology marine scientists reveal how these ... buoyancy and stay afloat. For most animals movement ...
Cached Biology News:Science selects 'Ask a Biologist' website to win SPORE award 2Science selects 'Ask a Biologist' website to win SPORE award 3Science selects 'Ask a Biologist' website to win SPORE award 4ASU’s Ask A Biologist website wins prestigious SPORE prize 2ASU’s Ask A Biologist website wins prestigious SPORE prize 3Whale sharks do the math to avoid that sinking feeling 2
(Date:7/10/2014)... 15, 2014 -- According to the International Atomic ... security comes from terrorists acquiring sufficient quantities of ... a crude nuclear explosive device. The IAEA also ... have involved gram-level quantities, which can be challenging ... to a new study appearing this week in ...
(Date:7/10/2014)... basis of psychiatric disorders has been extremely challenging because ... but are insufficient to cause disease. Now investigators reporting ... journal Cell Stem Cell describe a strategy ... interact with other risk factors or environmental exposures to ... pinpoints a genetic variant that may predispose individuals to ...
(Date:7/10/2014)... theatergoers have shelled out for crude 3-D glasses, ... viewing experience. These basic devices, used to trick ... may soon be rendered obsolete with the introduction ... University researchers. , TAU doctoral students Yuval Yifat, ... efficient holography based on nanoantennas that could be ...
(Date:1/15/2014)... interface is the device," Nobel laureate Herbert Kroemer ... be found at the junctures where layers of ... nanotechnology, the interfaces between layers of metal oxides ... high-tech favorites as spintronics, high-temperature superconductors, ferroelectrics and ...
Breaking Biology Technology:Sensitive detection method may help impede illicit nuclear trafficking 2New strategy could uncover genes at the root of psychiatric illnesses 2Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3A deeper look at interfaces 2
... drug discovery and development company eMetagen Corp . ... Marquette University Golden Angels Network , the angel investors ... Golden Angels investment, along with two grants received last ... the National Institutes of Health and a $150,000 Technology ...
... in any foreign land now requires a quick custom check. ... true nationality? What's this nation doing on the global scene ... Do I really like this nation? , ,It's no secret ... savvy than they were a decade ago. They clearly support ...
... - Ann Stunden, director of the Division of ... received a 2005 award for information technology leadership from ... honored Stunden for "strong and ground-breaking leadership in the ... 37 years ago." , ,A co-founder and executive ...
Cached Biology Technology:eMetagen gets $535,000 from MU angel investors 2Why are brands culturally profiled? 2Why are brands culturally profiled? 3
... (bluish-purple), DNA (blue), proteins (red) and acid polysaccharides ... traces: Ca ≤ 10 mg/kg Cd ≤ 5 mg/kg ... ≤ 5 mg/kg Fe ≤ 5 mg/kg K ≤ ... mg/kg Na ≤ 50 mg/kg Ni ≤ 5 mg/kg ...
... performance on minimum space. Thanks to a ... and cooling rates have been achieved that, ... maximum capacity of 48 x 0.2ml tubes, ... much more expensive 96 well instruments. Alternatively, ...
... available in a ready-to-use format. This ... dewaxing paraffin-embedded tissue sections prior to ... other analytical methods. The conventional method ... the slides in a series of ...
EZ-DeWax is a one-step solution that simultanously removes paraffin from and rehydrates formalin-fixed, paraffin embedded tissue...
Biology Products: