Navigation Links
PNAS study reveals why organs fail following massive trauma

& Immunology at the University of Rochester Medical Center, and an author of the PNAS study. "Beyond trauma, we believe that the techniques established here can provide insights into many disease that involve human immune system failure."

No Respite from Toxins

The human immune system is actually two systems developed at different points in human evolution. White blood cells of the more primitive innate system, like neutrophils and macrophages, form the first line of defense against disease. They swarm to the injury to engulf and destroy bacteria with toxic molecules and biochemicals. Because these same molecules and chemicals are also toxic to nearby human cells, the innate response is normally shut down quickly by the onset of the more time-consuming, precise and thorough adaptive immune system.

This second system pumps out an endless variety of immune cells on the hope that one or more will be the right shape to link up with, and become activated by, any invader encountered. When one of those immune cells, called lymphocytes, recognizes a bacterium or virus presented by the innate system, that lymphocyte expands into army of clones specifically designed to attack the invader at hand. Unfortunately, lymphocytes too are capable of mistakenly destroying human cells. Thus, they have developed quality control mechanisms where they can choose to stop expanding into an army (anergy) or to commit suicide (apoptosis).

The PNAS study offers new evidence that an overwhelming wave of biochemical signals created by the innate response after massive trauma can mistakenly trigger anergy and apoptosis, especially in T cell lymphocytes, shutting down the adaptive response before it can begin. Without the normal transition, the innate system continues to pump out toxic chemicals (cytokines) and molecules (free radicals) that tear at organs until they fail.

The goal of the current study was to identify the few genes and prote
'"/>

Source:University of Rochester Medical Center


Page: 1 2 3 4 5

Related biology news :

1. Bioartificial kidney under study at MCG
2. W.M. Keck Foundation funds study of friendly microbes
3. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
4. Genome-wide mouse study yields link to human leukemia
5. Clam embryo study shows pollutant mixture adversely affects nerve cell development
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Same mutation aided evolution in many fish species, Stanford study finds
8. Sequencing of marine bacterium will help study of cell communication
9. Genetically modified rice in China benefits farmers health, study finds
10. A new study examines how shared pathogens affect host populations
11. NYU study reveals how brains immune system fights viral encephalitis
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: PNAS study reveals why organs fail following massive trauma

(Date:5/22/2015)... 22, 2015  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... be ending its promotional pricing and making the Wocket generally ... Laurence Savin , Head of Marketing said, "We,ve extended the ... the end of May. To get your wocket at this ... open the store on June 1, you,ll receive a unique ...
(Date:5/22/2015)... -- According to a new market research ... Emotion, Forensic), by Software (Middleware, Databases), by Hardware (Cameras, Integrated ... Home) - Global Forecast to 2020", published by MarketsandMarkets, ... 2015 to $6.19 Billion by 2020, at a CAGR ... Tables and   43 Figures spread through 140 Pages ...
(Date:5/21/2015)... May 21, 2015 According ... Market by Solutions (Hardware, Software, Services), by Applications (Surveillance ... others), by End-Users (Military & Defense & Commercial) ... Thermal Imaging Market is expected to grow from ... 2020, at a Compound Annual Growth Rate (CAGR) ...
Breaking Biology News(10 mins):NXT-ID, Inc Announces Retail Price For Wocket Smart Wallet And Extends Discounted Promotional Price Till End Of May 2NXT-ID, Inc Announces Retail Price For Wocket Smart Wallet And Extends Discounted Promotional Price Till End Of May 3Facial Recognition Market Worth $6.19 Billion by 2020 2Facial Recognition Market Worth $6.19 Billion by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4
... and encoded in the brain is a central ... high cognitive function such as learning and memory. ... hippocampus of behaving rats, a brain region involved ... are associated with information processing during exploration and ...
... to advance imaging useful to medicine and security are ... image that appeared on old television screens., A team ... Sydney has created a way to control the length ... a new dimension of time to color and brightness ...
... ARC Centre of Excellence for Coral Reef Studies (CoECRS) ... help solve some of the world,s biggest environmental problems. ... at the ARC CoECRS, holds a joint position with ... the USA. Dr Hicks says more powerful economic ...
Cached Biology News:Brain waves encode information as time signals 2Timing is everything in new nanotechnology for medicine, security and research 2Timing is everything in new nanotechnology for medicine, security and research 3Linking social science and ecology to solve the world's environmental problems 2
(Date:5/22/2015)... DUBLIN , May 22, 2015  Actavis plc ... of the U.S. Court of Appeals for the Second ... 2014 preliminary injunction requiring the Company to continue distribution ... Logo - http://photos.prnewswire.com/prnh/20130124/NY47381LOGO   ... uphold this ruling, we intend to continue our strong ...
(Date:5/22/2015)... According to a new market ... Gel Electrophoresis, Agarose & Polyacrylamide Gel, Capillary Electrophoresis, Isoelectric ... & by End User - Global Forecast to 2020", ... reach around $1.98 Billion by 2020 with a CAGR ... Browse 226 ma rket data ...
(Date:5/22/2015)... Charm Sciences, Inc. is pleased ... (USDA), Grain Inspection, Packers and Stockyards Administration (GIPSA) ... Sciences to monitor aflatoxin in grains utilizing Charm’s ... FAST Aflatoxin Quantitative Test (solvent-based). , The Charm ... Water Extraction Technology to extract aflatoxin from the ...
(Date:5/22/2015)... Knowledgent , the data and analytics ... potential of big data analytics in the life sciences ... help life sciences and healthcare organizations understand the ways ... business insights. , The life sciences and healthcare industries ... patient profiling, compliance and regulatory requirements, and scientific research. ...
Breaking Biology Technology:Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 2Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 3Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 4Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 5Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 6Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 7Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 8Electrophoresis Market Worth $1.98 Billion by 2020 2Electrophoresis Market Worth $1.98 Billion by 2020 3Electrophoresis Market Worth $1.98 Billion by 2020 4USDA-GIPSA (FGIS) Awards 5 Year Contract for Aflatoxin Tests to Charm Sciences 2New White Paper Explores the Potential of Big Data Analytics in Life Sciences and Healthcare 2
... Kauten. Source: Teresa Esser. Ralph is one of the ... bioscience, said Frank Langley, president and CEO of Point One ... to admit that his success in high-tech entrepreneurship is somehow ... said in an interview. Ive been a lucky guy. , ...
... Wisconsin could lose its carefully established position as ... more money is not channeled into academic and other research ... the report (5.4 MB PDF) This prediction comes ... the governor on technological matters. The report, titled The Economic ...
... The difficult part is finding meaning. When researching the ... of information. , ,The differences between information and intelligence ... process for gathering information ensures that the results will ... well-defined purpose allows you to search the Internet broadly ...
Cached Biology Technology:Ralph Kauten on how to raise angel financing 2Ralph Kauten on how to raise angel financing 3Ralph Kauten on how to raise angel financing 4Economic report raises red flags on Wisconsin's future 2Economic report raises red flags on Wisconsin's future 3Are you gathering information or intelligence about competitors? 2Are you gathering information or intelligence about competitors? 3
biotin-4-fluorescein...
... of the LVF-UV-HL, LVF-CUV-ADP, FHS-LVF and CVD-Diffuse ... low-pass Linear Variable Filters to create the ... center wavelength and adjustable bandpass. Each filter ... blocking band (99.8%). These filters -- ...
... Clone/PAD: ZMD.414. Immunogen: Synthetic peptide ... mouse and rat mTOR (Mammalian target of ... for the human mTOR protein. On ... at ~235 kDa. Reactivity: Human (positive ...
Protein Kinase D2 Immunogen: Human protein kinase D2. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: