Navigation Links
PNAS study reveals why organs fail following massive trauma

Massive trauma, say from a sabertooth tiger attack, meant immediate death for the primitive human. Modern man is more likely to survive severe injury caused by a car crash, gunshot or fall thanks to high-tech emergency medicine. Unfortunately, the body does not know what to do when it survives an injury that would have been fatal until recently in human evolution. Nearly one third of the time, mechanisms in place to protect people from disease misfire seven to ten days after severe injury, causing multiple organ failure. That is one reason why trauma is the leading cause of death for Americans aged 44 and younger.

A nationwide team of researchers is working urgently on the problem of post-trauma immune system and organ failure, and has discovered several new biochemical pathways that play a central role, according to a study published today in the Proceedings of the National Academy of Sciences (PNAS). Inventing new techniques along the way, the team is changing emergency room guidelines, building the foundation for earlier diagnosis of post-trauma organ failure and making possible the design of drugs to reverse it.

Trauma has become a federal research priority because the survival rate has not improved in 10 years. Excitement is growing, however, because new evidence suggests that major diseases involving the immune system share some of the same mechanisms and may be cured by manipulating the same molecules. A protein called programmed cell death 1 (PD1), for example, suggested by the PNAS paper as playing a role in post-trauma organ failure, is also involved in the immune system breakdown leading to AIDS, according to an article in the August edition of Nature.

"Our study proves for the first time that it is possible to identify the genetic and protein changes in specific immune cells that play a significant role in determining whether or not trauma is fatal," said Carol L. Miller-Graziano, Ph.D., professor of Surgery and of Microbiology
'"/>

Source:University of Rochester Medical Center


Page: 1 2 3 4 5

Related biology news :

1. Bioartificial kidney under study at MCG
2. W.M. Keck Foundation funds study of friendly microbes
3. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
4. Genome-wide mouse study yields link to human leukemia
5. Clam embryo study shows pollutant mixture adversely affects nerve cell development
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Same mutation aided evolution in many fish species, Stanford study finds
8. Sequencing of marine bacterium will help study of cell communication
9. Genetically modified rice in China benefits farmers health, study finds
10. A new study examines how shared pathogens affect host populations
11. NYU study reveals how brains immune system fights viral encephalitis
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: PNAS study reveals why organs fail following massive trauma

(Date:11/18/2014)... , Nov. 18, 2014   EyeLock Inc. ... solutions, and MorphoTrust USA (Safran), a ... today announced a strategic partnership to offer comprehensive ... vehicle administration (MVA), airport screening and financial services ... solutions, MorphoTrust serves consumers through a nationwide network ...
(Date:11/10/2014)... shelves in early 2010, and people have used them ... be tossed into a washing machine without ever having ... though, has come with risks for young children. , ... found that from 2012 through 2013, U.S. poison control ... years of age swallowing, inhaling, or otherwise being exposed ...
(Date:11/6/2014)... groundbreaking paper from a team of Florida State University ... plants could adapt to and survive environmental swings such ... the latest issue of the journal The Plant ... of DNA and proteins) is organized in a cell ... genes are turned on and others are turned off. ...
Breaking Biology News(10 mins):EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3Study finds laundry detergent pods, serious poisoning risk for children 2Maize analysis yields whole new world of genetic science 2
... (Nasdaq: AWRE ), a leading supplier of broadband ... discuss the company,s operating results for the fourth quarter and ... p.m. Eastern Time. CEO Michael Tzannes and CFO Rick Moberg ... by Thomson and can be accessed on the Investor Relations ...
... French . , Lack of sleep ... involuntarily during the day poses a very real and ... Institute (MNI) at McGill University demonstrates interestingly, that sleep-wake ... cells (neurons), melanin-concentrating hormone (MCH) neurons and orexin (Orx) ...
... Taking a hint from the text comparison methods ... and computer programs, University of California, Berkeley, researchers ... genome sequences. With nearly a thousand genomes ... comparative genomics as a way to construct evolutionary ...
Cached Biology News:Aware Announces Q4 and FY2008 Earnings Conference Call 2What happens when we sleep 2New computational technique allows comparison of whole genomes as easily as whole books 2New computational technique allows comparison of whole genomes as easily as whole books 3New computational technique allows comparison of whole genomes as easily as whole books 4New computational technique allows comparison of whole genomes as easily as whole books 5New computational technique allows comparison of whole genomes as easily as whole books 6
(Date:11/23/2014)... WI (PRWEB) November 23, 2014 ... and supplier of fine chemical ingredients to the ... the launch of its new website, Apiscent.com. , ... of Apiscent Labs, clean design, easy navigation, rotating ... make Apiscent Labs stand out. , ...
(Date:11/22/2014)... Colo. (PRWEB) November 21, 2014 ... proprietary cloud based analytics and scientific testing methodologies relating ... commitment for a $750,000 line of credit from an ... extremely pleased to have secured this commitment from one ... Executive Officer of CannLabs. “This capital will help accelerate ...
(Date:11/22/2014)... Respiratory therapy students will soon ... of life-like respiratory ailments using the latest in ... Rapids-based, Michigan Instruments Inc. developers of the world-renowned ... respiratory simulation units to the pro-gram, which cost ... Muskegon Community College are collaborating to offer Muskegon’s ...
(Date:11/21/2014)... England , Nov. 21, 2014   TRU-D SmartUVC ... will feature their superbug-killing UVC automated disinfection robot, TRU-D SmartUVC, ... this week from Nov. 23 to 26 at Stand 23. ... is the United Kingdom,s largest infection-related ... infection prevention societies to one of the leading events of ...
Breaking Biology Technology:CannLabs Secures $750,000 Line Of Credit 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 3TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 3
... Sept. 17 Keryx Biopharmaceuticals,Inc. (Nasdaq: KERX ... the,Company,s President, will present an overview of the ... 37th Annual Investment Conference,in San Francisco. Dr. Henderson,s ... 8:30 am PT. Dr. Henderson,s presentation will ...
... Genetics,(Amex: ILI ) today announced that its ... will present at the Immunotoxicology V,Conference on September ... on innovative methods and applications for risk assessment ... that includes industry regulators and some,of the industry,s ...
... led by the U.S. Department of Energy,s Argonne National ... of new mechanisms, which makes it possible to switch ... enable computers to more accurately write and store information. ... Hamburg used a special scanning tunneling microscope equipped with ...
Cached Biology Technology:Keryx Biopharmaceuticals to Present at Bank of America Investment Conference 2Interleukin Genetics President and Chief Scientific Officer to Present at Immunotoxicology V Conference 2Interleukin Genetics President and Chief Scientific Officer to Present at Immunotoxicology V Conference 3Researchers improve ability to write and store information on electronic devices 2
... Mynox is the first biological ... killing them, and not just ... the only anti-mycoplasma agent that ... virus stocks directly. The cytotoxicity ...
... Acridinium NHS ester can ... and nucleic acids. The covalently ... produce chemiluminescence in the presence ... ester-labeled proteins can be used ...
... assay (EMSA) is a powerful tool for ... gel shift or gel retardation, the assay ... subjected to electrophoresis, free DNA will migrate ... LightShift Chemiluminescent EMSA Kit is a nonradioactive ...
... Cytomics FC 500 Series is ... with the most advanced technologies ... delivers flexible testing, powerful software ... that help researchers optimize their ...
Biology Products: