Navigation Links
PGA on a tour under the skin

The microorganism Staphylococcus epidermidis is harmless on human skin, but it is the leading cause of hospital-acquired infections and infections of indwelling medical devices. S. epidermidis is associated with an enormous number of infections in people with prosthetic joints, replacement heart valves, and intravenous catheters, and antibiotic resistance makes it tough to battle. Moreover, the mechanism through which the organism becomes so pathogenic once the protective barrier of the skin is removed remains unclear.

In their study appearing online on February 3 in advance of publication in the March 1 print edition of the Journal of Clinical Investigation,.Michael Otto and colleagues from Rocky Mountain Laboratories demonstrate that S. epidermidis secretes an extracellular polymer called poly-gamma-glutamate (PGA) to facilitate growth and ensure survival of the bacteria inside the human host. PGA protects the pathogen from innate host defenses during infection. S. epidermidis is the only human pathogen known to produce PGA other than Bacillus anthracis, but several differences exist in how the two pathogens use PGA to their advantage. PGA is currently used as an antigen for vaccine production against Anthrax

This paper presents PGA as a promising target for drug development aimed at combating these hospital-acquired infections and other illnesses caused by related bacteria.


'"/>

Source:JCI


Page: 1

Related biology news :

1. Bioartificial kidney under study at MCG
2. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
3. Zebrafish may hold key to understanding human nerve cell development
4. Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
5. Researchers make gains in understanding antibiotic resistance
6. Brain-mapping technique aids understanding of sleep, wakefulness
7. New understanding of DNA repair may pave way to cancer treatments
8. Researchers discover underwater volcano
9. New World founders small in number
10. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
11. Virologists make major step towards understanding the process of HIV infection
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... 23, 2017 Research and Markets has announced ... & Trends - Industry Forecast to 2025" report to their ... The ... CAGR of around 8.8% over the next decade to reach approximately ... the market estimates and forecasts for all the given segments on ...
(Date:3/22/2017)... 21, 2017 Optimove , provider ... retailers such as 1-800-Flowers and AdoreMe, today announced ... and Replenishment. Using Optimove,s machine learning algorithms, these ... and replenishment recommendations to their customers based not ... of customer intent drawn from a complex web ...
(Date:3/20/2017)... 2017 At this year,s CeBIT Chancellor Dr. ... DERMALOG. The Chancellor came to the DERMALOG stand together with the Japanese ... CeBIT partner country. At the largest German biometrics company the two government ... and iris recognition as well as DERMALOG´s multi-biometrics system.   ... ...
Breaking Biology News(10 mins):
(Date:8/14/2017)... ... August 14, 2017 , ... Opal Kelly, ... USB or PCI Express, announced the release of SYZYGY™, a new open standard ... the need for a compact, low cost, low pin-count, high-performance connectivity solution between ...
(Date:8/11/2017)... 11, 2017  Market researcher Kalorama Information ... article regarding the telemedicine market.  The telemedicine ... Information.  The article, "Heart and Asthma ...  used information from Kalorama Information,s Remote Patient ... Market  (Sleep, Diabetes, Vital Signs /EKG ...
(Date:8/11/2017)... Glendale, Calif. (PRWEB) , ... August 11, 2017 , ... ... a plant collagen-based formulation unlocking collagen like never before. , Collagen is the ... many firsts to market with Liquid Collagen™, which include: , ...
(Date:8/10/2017)... ... August 09, 2017 , ... ... agriculture industry reach its ideal customers with the right message. Their effective, cutting-edge ... a Midwest company, we realize how crucial the agriculture industry is,” said David ...
Breaking Biology Technology: