Navigation Links
PET/MRI scans may help unravel mechanisms of prenatal drug damage

Scientists have demonstrated a new way to assess the potentially damaging effects of prenatal drug exposure--a technique that could also be used to monitor a fetus's response to therapeutic drugs--using sophisticated, noninvasive medical imaging tools. Scientists at the U.S. Department of Energy's Brookhaven National Laboratory, whose findings are reported in the February issue of the Society of Nuclear Medicine's Journal of Nuclear Medicine, used positron emission tomography (PET) combined with magnetic resonance imaging (MRI) to track the uptake and distribution of trace amounts of cocaine in pregnant monkeys and found significant differences in where and how fast the drug accumulates in maternal and fetal organs.

"Understanding how drugs are transferred between a mother and her fetus during pregnancy may help us unravel the mechanisms of the drug's damaging effects on unborn children," said SNM member Helene Benveniste, M.D., Ph.D., chair of Brookhaven's medical department in Upton, N.Y., and lead author of the paper, "Maternal and Fetal 11C-Cocaine Uptake and Kinetics Measured In Vivo by Combined PET and MRI in Pregnant Nonhuman Primates."

"While studies that follow human drug abusers and their children over decades provide valuable information, animal studies can more quickly provide clues to the underlying mechanisms of damage and suggest ways to test new treatment or prevention strategies," said Benveniste.

The imaging tools could also be used to assess the effects of therapeutic drugs, such as administering synthetic narcotics to pregnant women following surgical procedures performed on fetuses in utero. "Following such surgeries, which are becoming more common to correct congenital malformations, the mother is treated with narcotics for pain--and anesthesiologists are relying on the mother transferring the pain medication to the fetus via the placenta. But we actually do not know if what we give is sufficient to 'satisfy' the pain lev
'"/>

Source:Society of Nuclear Medecine


Page: 1 2 3 4

Related biology news :

1. Researchers use brain scans to predict behavior
2. Retinal scans eyed for New Mexico show cattle
3. Using brain scans, researchers find evidence for a two-stage model of human perceptual learning
4. A puzzle piece found in unraveling the wiring of the brain
5. Scientists journey to southern Africa to unravel the secret world of elephant communication
6. ORNL, UC Berkeley unravel real-world clues to Earths mysteries
7. UT Southwestern researchers unravel control of growing blood vessels
8. University of Arizona plant scientists to unravel maize genome
9. UW scientists unravel critical genetic puzzle for flu virus replication
10. Researchers unravel DNA tangles and enzyme seamstresses
11. UGA scientists unravel molecular inch-worm structure of walking-pneumonia bacterium
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: PET MRI scans may help unravel mechanisms prenatal drug damage

(Date:12/19/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has ... America Perimeter Security Systems Market" report to their offering. ... North American perimeter security market is estimated to grow at ... U.S. market holds a larger share in this market, ...
(Date:12/17/2014)... , Dec. 15, 2014 Research and Markets ... "Samsung Galaxy S5 - Home Button Synaptics Fingerprint ... http://photos.prnewswire.com/prnh/20130307/600769 Based ... 5S, Samsung introduces for the first time a fingerprint ...
(Date:12/17/2014)... N.C. , Dec. 16, 2014 Valencell, a ... its PerformTek biometric technology to industry leaders such as ... accurate, clinically validated, biometric wearable products. These products will ... in Las Vegas . ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2
... Results showed that the microbes in about a half a ... the rumen, the largest chamber of a cow's stomach - ... voltage needed to run one rechargeable AA-sized battery, said Ann ... agricultural and biological engineering at Ohio State University. , While ...
... develops, neurons reach out helter-skelter forming new connections, only ... brain chooses which connections to keep and which to ... have the most electrical activity—a finding that could help ... The work, published in the April 21 issue of ...
x...
Cached Biology News:It's electric: Cows show promise as powerplants 2It's electric: Cows show promise as powerplants 3Speak up: Louder neurons form more connections 2
(Date:1/22/2015)... BOSTON , Jan. 22, 2015  Transwestern | RBJ today ... feet of office space for Shire a leading biopharmaceutical company, ... . Transwestern | RBJ,s Robert Richards , president, and ... the lease for the entire five-floor building at 95 Hayden ...
(Date:1/22/2015)... 22, 2015 Pipette.com has added the ... their comprehensive portfolio of Eppendorf products. , The Eppendorf ... a Centrifuge 5424/5424 R and receive the following:, ... Research plus or Eppendorf Reference 2 , ...
(Date:1/22/2015)... 2015 Diagenode, Inc., a leading ... Bioruptor® and complete solutions for epigenetics research, recently ... alleviating the need for manual processing. The new ... ChIP of histones or transcription factors and a ...
(Date:1/22/2015)... , Jan. 22, 2015  Derma Sciences, Inc. ... company focused on advanced wound care, announces that ... tissues, have been added to the Premier, Inc. ... the opportunity for the AMNIOEXCEL® and AMNIOMATRIX® product ...
Breaking Biology Technology:Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5
... October 31, 2008 at 11:00 am EASTERN, DUBLIN, ... ), a leading developer and manufacturer of diagnostic products,for ... for the third quarter of fiscal year 2008 on ... call for that same,day, Friday, October 31, 2008, at ...
... 20th EORTC-NCI-AACR Symposium --, SEATTLE and GENEVA, ... DNDN ) today presented preclinical data on its,lead ... cation channel protein also known as Trp-M8), supporting,Trp-p8 ... titled, "Preclinical Validation of the TrpM8 Ion Channel ...
... ROCKVILLE, Md., Oct. 23 EntreMed, Inc.,(Nasdaq: ... developing,therapeutics for the treatment of cancer and ... data for its Aurora,A/angiogenesis kinase inhibitor, ENMD-2076. ... Division of Medical Oncology, University of Colorado, ...
Cached Biology Technology:Trinity Biotech plc to Announce Third Quarter 2008 Financial Results on October 31, 2008 2Dendreon Presents Preclinical Data Validating Anti-Tumor Activity of D-3263, a Trp-p8 Agonist 2Dendreon Presents Preclinical Data Validating Anti-Tumor Activity of D-3263, a Trp-p8 Agonist 3EntreMed's ENMD-2076 Demonstrates Tumor Regression in Human Colon Cancer Model 2EntreMed's ENMD-2076 Demonstrates Tumor Regression in Human Colon Cancer Model 3
Autoclavable, variable volumefitted w./ an anti-drip safety valve; borosilicate glass barrelprotected with transparentpolypropylene sleeve; spring-lock cursor design ensuresfine adjustment for exact ...
Disposable tips with floating filter (US Patent 6,702,990) for PDM1.5 OneTouch Plus spotpicker, 10 racks of 96, DNAse and RNAse free...
...
... is aseptically collected via cardiac puncture from 3 ... mixed sex). It is then centrifuged and frozen ... filtered and bottled at 4C then stored at ... HAVE ALWAYS USED PEL-FREEZ COMPLEMENT, YOU CAN NOW ...
Biology Products: