( e paper. “The significant enhancements ...)PANTHER Protein Classification System Database 5.0

e paper. “The significant enhancements in the latest version provide the scientific community with a wealth of freely available information and tools to advance systems biology. We are honored that the PANTHER system has been accepted as an InterPro member database and look forward to working with the community to further advance this resource.?The PANTHER system functional annotations of fruit fly genes have been available for two years as part of an ongoing collaboration with FlyBase. “The task of performing functional annotation of genomes is challenging. Too often we rely simply on transitive annotation based on a BLAST match. The PANTHER system offers a much more sophisticated system for predicting gene function from sequence,?said Michael Ashburner, Ph.D., Professor of Genetics at Cambridge University and a founder and co-principle investigator of FlyBase. “Our collaboration with the PANTHER system has been excellent and very informative for the annotation of the Drosophila genome.?This week’s release includes functional annotation information for human, mouse and rat genes in addition to the Drosophila genes. The PANTHER system database consists of a library of 6,683 protein families, divided into 31,750 functional subfamilies, and covering approximately 90% of mammalian protein coding genes. The Web-based interface allows life scientists to browse or analyze large sets of genes by their known or inferred biological functions and explore more than 60 pathways associated with protein families, subfamilies, and training sequences using diagrams drawn by expert curators. The new PANTHER system Pathway Module is the result of an ongoing collaboration with the Systems Biology Institute (SBI) in Tokyo, led by Dr. Hiroaki Kitano, a founding member of the SBML (Systems Biology Markup Language) Consortium. The CellDesigner software (http://www.celldesigner.org) developed by Dr. Kitano’s group was used to draw all of the pathways available on the PANTHER system Web sit
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Source:Applied Biosystems Press Release


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