Navigation Links
Outsmarting the smartie bug

New tools in the fight against pneumococci ?the bugs targeted by vaccines recently announced by the Department of Health ?are described by a team led by scientists from the Wellcome Trust Sanger Institute. They have put together a complete description of the targets of the vaccine that will help monitor the disease and provide new tools for rapid diagnosis.

Pneumococci (formal name Streptococcus pneumoniae) are widespread, causing non-invasive disease, such as ear and sinus infections, and rarer, invasive disease, such as pneumonia and meningitis. About one in three children each year has an ear infection, of which about one-third will be due to the pneumococcus. More significantly, invasive disease is a major cause of death: around 1 million people, mostly young children in developing countries, die each year.

The research, published online today in PLoS Genetics, shows how the target of the vaccines, called the polysaccharide capsule, has evolved and allows the researchers to determine functions of the genes involved. The polysaccharide capsule forms a sugary coat around the bacterium and changing the structure of the capsule can help it to fool our immune defence systems ?like a Smartie changing its colour.

"The bug has a polysaccharide coat which can take any one of 90 different forms, known as serotypes," said Stephen Bentley, leader of the project at the Wellcome Trust Sanger Institute. "The coat is essential for its ability to cause disease and its interaction with our immune system and some serotypes are more likely to be associated with disease."

"The current vaccines provide excellent protection against pneumococcal disease, but only that caused by some of the 90 serotypes, and it is important that we keep a watch on the development of this organism. Our work in describing all known variants will help in that surveillance"

Two vaccines are available. The first, PCV, recognizes seven forms of the capsule and protec
'"/>

Source:Public Library of Science


Page: 1 2 3

Related biology news :

1. New insight into people who see colors in letters and numbers
2. Alaskan puzzles, monitoring provide insight about North Pacific salmon runs
3. New insight into regulation of blood stem cells
4. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
5. New insights into how Huntingtons disease attacks the brain
6. Gambling monkeys give insight into neural machinery of risk
7. Structures of marine toxins provide insight into their effectiveness as cancer drugs
8. Flies on speed offer insight into the roles of dopamine in sleep and arousal
9. Grasshopper love songs give insight into sensory tuning
10. Studies on human genome variation provide insight into disease
11. Study provides insight into cellular defenses against genetic mutation
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Outsmarting the smartie bug

(Date:7/21/2015)... , July 21, 2015 Today, ZTE ... Already received as well as expected revenues in 2015 that relate ... FPC,s communicated revenue guidance of approximately 2,200 MSEK for 2015. ... is a leading smartphone manufacturer in China ... FPC1 02 5 for Axon , ...
(Date:7/13/2015)... 13, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market, ... 62/188684 for BEHAVIORAL-DIRECTED AUTHENTIATION METHOD AND ... and secure method to make payments.  With this ... introduced with its groundbreaking voice-direct payment patent application, ...
(Date:7/8/2015)... , July 8, 2015 Summary Pancreatic ... the fourth most fatal, with a mortality rate of ... prognosis of pancreatic cancer patients has highlighted a significant ... is not being met by the current market. ... of products with varying molecule types and mechanisms of ...
Breaking Biology News(10 mins):FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 3
... the University of Leeds, UK, the Charit University Medical ... Medicine (MDC) in Berlin, Germany, have discovered a new ... identified how ,junk, DNA promotes the growth of cancer ... (University of Leeds) and Dr Stephan Mathas (Charit, MDC) ...
... estimated that nearly 1.5 million Americans have been diagnosed with ... are believed to have some form of autism, according to ... and Prevention (CDC). Find out what new research and treatment ... ASD seen over the past few decades at a panel ...
... Heart and liver transplant recipients are at particularly ... donated organ, researchers report at the 2nd European Lung ... such cancers in these patients to maximize the chance ... for decades that the immunosuppressive drugs given to transplant ...
Cached Biology News:'Junk DNA' drives cancer growth 2Expert panel to discuss autism spectrum disorders 2Lung cancer risk particularly high for heart and liver transplant recipients 2
(Date:7/30/2015)... According to a new market ... PB/PK, PKPD, Trial Design, Toxicity Prediction, In-house, Contract Service), ... by End Users - Global Forecast to 2020", published ... USD 2,107.99 million by 2020 from USD 1,034.93 million ... Browse more than 75 ...
(Date:7/30/2015)... 30, 2015 Ascendis Pharma A/S (Nasdaq: ... its innovative TransCon technology to address significant unmet ... a six-month Phase 2 study to evaluate the ... in 53 treatment-naïve, pre-pubertal children with growth hormone ... pleased with the top-line results from our Phase ...
(Date:7/29/2015)... , July 30, 2015 ... results for the second quarter of 2015. CEO ... results and its performance in different businesses. ... http://www.eurobusinessmedia.com/ceo-direct/sanofi/sanofi-h1-2015-results-interview-with-ceo-olivier-brandicourt?utm_source=ceo-direct&utm_medium=wire Topics covered ... results - Performance drivers ...
(Date:7/29/2015)... , July 29, 2015 /PRNewswire/ - BioAmber Inc. (NYSE: ... the Company,s Chief Financial Officer has resigned.  The Company ... Financial Officer who retired in December 2014, as full ... a permanent successor.     Andy Ashworth ... and ensure a smooth transition.  Andy was the Company,s ...
Breaking Biology Technology:Biosimulation Market Worth 2,107.99 Million USD by 2020 2Biosimulation Market Worth 2,107.99 Million USD by 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 4Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 5Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 6Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 7BioAmber Announces Change in Chief Financial Officer 2BioAmber Announces Change in Chief Financial Officer 3
... Physicists at the University of California, Berkeley, have built the ... the diameter of a human hair that requires only a ... , The scientists successfully received their first FM broadcast last ... Boys, "Good Vibrations" transmitted from across the room. In homage ...
... 31 /PRNewswire-FirstCall/ - Dragon Pharmaceutical Inc.,(TSX: DDD; ... its biotech method,for 7ACA production has been ... believes this achievement validates the Company,s research,and ... This,technology would bring immediate benefits to production ...
... CRANBURY, N.J., Oct. 31 Amicus Therapeutics,(Nasdaq: ... small molecule,orally-active pharmacological chaperones for the treatment ... for the third quarter of 2007.,On a ... Generally Accepted,Accounting Principles (GAAP), Amicus announced a ...
Cached Biology Technology:World's smallest radio uses single nanotube to pick up good vibrations 2World's smallest radio uses single nanotube to pick up good vibrations 3World's smallest radio uses single nanotube to pick up good vibrations 4Dragon Announces R&D Achievement in Biotech Manufacturing Process 2Dragon Announces R&D Achievement in Biotech Manufacturing Process 3Amicus Therapeutics Announces Third Quarter 2007 Financial Results 2Amicus Therapeutics Announces Third Quarter 2007 Financial Results 3Amicus Therapeutics Announces Third Quarter 2007 Financial Results 4Amicus Therapeutics Announces Third Quarter 2007 Financial Results 5Amicus Therapeutics Announces Third Quarter 2007 Financial Results 6Amicus Therapeutics Announces Third Quarter 2007 Financial Results 7Amicus Therapeutics Announces Third Quarter 2007 Financial Results 8
... PHD2000 syringe pump series combines Harvard Apparatuss best ... and a wide range of configuration options. A ... dimensions of syringes from all the major manufacturers. ... all the pertinent information from across the lab. ...
Mouse monoclonal antibody to RAD51L3 - RAD51-like 3 (S. cerevisiae)...
... you to store and manage very large ... secure central relational database. Storing and managing ... resource for clone tracking and enables you ... analysis. LabShare software integrates seamlessly with Invitrogen's ...
... A and Protein G bind specifically to ... A and Protein G conjugates are commonly ... (antibodies) and immunoglobulin subtypes from serum, hybridoma ... biological fluids. These reagents are also commonly ...
Biology Products: