Navigation Links
Osteoarthritis may be sign of faster 'biological ageing'

Osteoarthritis, the degenerative inflammatory bone disease, may be a sign of faster "biological ageing," suggests research published ahead of print in the Annals of the Rheumatic Diseases.

The authors base their findings on a study of almost 1100 people, aged between 30 and 79. Most of them were female twins.

X-rays of both hands were taken of all participants to check for signs of osteoarthritis and a blood sample was taken to assess "biological ageing" in white cell DNA.

Biological ageing is likely to be reflected by the gradual shortening of telomeres, the length of DNA which caps the tips of chromosomes. A host of factors make them shorten over time, including insufficient repair of the damage caused by oxygen free radicals (oxidative stress).

Oxygen free radicals are the unstable molecules produced as a by-product of normal bodily processes, as well as external factors, such as tobacco, alcohol, and sunlight.

Osteoarthritis is the most common form of arthritis, with the hands being one of the sites most often affected. Its frequency rises dramatically with age, but it is still not known exactly what causes it.

Unsurprisingly, the findings showed that white cell telomere lengths were associated with chronological age. The older a person was, the shorter they were.

But among the 160 people with hand osteoarthritis, the telomere length was significantly shorter than among those without the disease, even after taking account of influential factors, such as obesity, age, sex, and smoking.

All those with hand osteoarthritis were over 50, and the amount of telomere shortening was equivalent to that accrued over 11 years in healthy people (178 base pairs).

Telomere length was also significantly associated with the severity of osteoarthritis. The more severe the disease, the shorter was the telomere length.

The authors suggest that both the ageing process and osteoarthritis share bi
'"/>

Source:BMJ Specialty Journals


Page: 1 2

Related biology news :

1. Quantum dots provide a faster, more sensitive method for detecting respiratory viral infections
2. Muscle repair: Making a good system better, faster; implications for aging, disease
3. Neanderthal teeth grew no faster than comparable modern humans
4. Mosquito study shows new, faster way West Nile can spread
5. Clean skies=faster global warming?
6. Jefferson biologist coaxing human embryonic stem cells to make dopamine with simpler, faster method
7. Picking particles faster than one at a time
8. Cortex matures faster in youth with highest IQ
9. Researchers develop portable vein finder for faster, more accurate injections
10. Why nerve cells work faster than the theory allows
11. Birds going extinct faster due to human activities
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Osteoarthritis may sign faster biological ageing

(Date:4/27/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces that its Wocket® ... first week of May, 2015 and will be fulfilling ... Gino Pereira , Chief Executive Officer ... as Wocket® enters the consumer market. We would like ...
(Date:4/21/2015)... 21, 2015 High crime ... are boosting access control systems market in ... a recently published report by TechSci Research " Saudi ... access control systems market in Saudi Arabia ... 2020.The access control systems market in the Kingdom is ...
(Date:4/20/2015)... 2015 The announcement comes as ... Records Management (GRM), Ireland,s foremost records ... Having built up an impressive track record of clients within ... within the records management sector in Dubai ... GCC staffbase and employ a further eight staff members at ...
Breaking Biology News(10 mins):Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3
... Americans, protects some people with heart failure, enabling them ... a research team led by investigators at the University ... Washington University School of Medicine in St. Louis. The ... beta-blockers, a class of drugs used to treat chronic ...
... computer simulation has revealed a self-healing behavior in ... of radiation-resistant materials for nuclear power plants and ... of Energy,s Pacific Northwest National Laboratory found that ... damage in the engineered ceramic yttria-stabilized zirconia. ...
... shows clearly that powerful starquakes ripple around the Sun in ... surface. The observations give solar physicists new insight into a ... studying other stars. The outermost quarter of the Suns ... in this region causes ripples that criss-cross the solar surface, ...
Cached Biology News:Genetic variant mimics effect of heart failure medications 2Genetic variant mimics effect of heart failure medications 3Genetic variant mimics effect of heart failure medications 4Ceramic, heal thyself 2Solar flares set the Sun quaking 2
(Date:5/4/2015)... TEL AVIV, Israel , May 4, 2015 /PRNewswire/ ... has filed its annual report on Form 20-F for ... U.S. Securities and Exchange Commission ("SEC"). The annual report ... for the development of antibodies in the area of ... antibodies with superior qualities of high specificity and binding ...
(Date:5/4/2015)... 2015 /PRNewswire/ - The Fight Against Cancer Innovation ... announce the formation of Turnstone Biologics Inc. (Turnstone), ... cancer that harness the patient,s own immune system. ... between the Children,s Hospital of Eastern ... the Ontario Institute for Cancer Research (OICR), the ...
(Date:5/4/2015)... Achieved primarily through a proprietary paraffin ... 10 to 100x better detail than the industry standard. ... existing light microscopy methods, it needed another medium to ... the frame of reference because it represents the highest ... from the earliest discovery days of Ultralight Histology was ...
(Date:5/4/2015)... , May 4, 2015 ... thousands of med students prepare for the United States ... world-leading provider of scientific, technical and medical information products ... free MOOC (Massive Open Online Course) designed to help ... Examination (USMLE) Step 1, the first and most daunting ...
Breaking Biology Technology:Tikcro Technologies Files Annual Report on Form 20-F for the Year Ended December 31, 2014 2Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 2Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 3Elsevier's Free MOOC Prepares Med Students for Licensing Exam 2Elsevier's Free MOOC Prepares Med Students for Licensing Exam 3
... to a multiplex near you, but movies showing the ... have blockbuster potential. A team of scientists with the ... of California (UC) Berkeley has developed a technique for ... that chemical reactions in the liquids can be imaged ...
... development of new applications based on nanoimprinting techniques (NIL) is ... challenges to be overcome in order to reach the market? ... its uptake from the industry? What are the tools needed ... exactly with this topic, i.e. Nanopatterning, Production and Applications based ...
... 20, 2012     On May 21-23, 2012, ... created to support, mentor, and develop minority-, woman-, ... host its fifth annual networking conference and EXPO ... health advocate, will address the conference held at ...
Cached Biology Technology:First atomic-scale real-time movies of platinum nanocrystal growth in liquids 2First atomic-scale real-time movies of platinum nanocrystal growth in liquids 3First atomic-scale real-time movies of platinum nanocrystal growth in liquids 4First atomic-scale real-time movies of platinum nanocrystal growth in liquids 5Low-cost optical components through nanoimprinting lithography 2Low-cost optical components through nanoimprinting lithography 3Music Legend And Health Advocate Bret Michaels To Address Diversity Alliance For Science 2012 National Conference And EXPO 2Music Legend And Health Advocate Bret Michaels To Address Diversity Alliance For Science 2012 National Conference And EXPO 3
... Modular system for large format and ... six lab-cast or precast gels (26 ... or 24-cm Immobiline DryStrip gels.Simple-to-use 1.0-mm ... design simplifies loading and unloading.Built-in ceramic ...
Edited by P.J. Delves (1997) An up-to-date review of antibody-raising technologies, this volume provides researchers with immediate access to the protocols they require every day....
Request Info...
MOUSE ANTI HUMAN FACTOR I...
Biology Products: