Navigation Links
Optimizing cell therapy against tumors is a balancing ACT

Adoptive cell transfer (ACT) therapy is used to treat patients with metastatic solid tumors. ACT involves the removal of some of the patient's cancer cells, and some of their immune T cells. When the cells are mixed together, specific parts of the cancer cells that stimulate the T cells to cause an immune attack can be identified. The T cells get expanded and re-infused into the patient to mount an immunological, anti-cancer response against the tumors. One of the challenges faced is selecting the appropriate T cells with proper antigen specificity.

In a new study appearing in the June 1 print issue of The Journal of Clinical Investigation, Nicholas Restifo and colleagues identified which cells are optimal for treating large, vascularized, established tumors. The authors use a mouse model that mimics the human clinical situation. They find that phenotypic and functional qualities of T cells are associated with the ability of ACT to cause regression of large, established melanomas. Seemingly paradoxical, naïve and early effector T cells are more effective for tumor treatment than more differentiated T cells.

In an accompanying commentary, Daniel Speiser and Pedro Romero write, "optimal therapeutic efficacy may depend on different T cell selection and preparation strategies" and these findings indicate that a pragmatic strategy for ACT is to keep the in vitro T cell expansion phase as short as possible to keep them naïve. These findings are important for development of improved adoptive immunotherapy approaches for treating tumors and established infectious diseases.

TITLE: Acquisition of full effector function in vitro paradoxically impairs the in vivo anti-tumor efficacy of adoptively transferred CD8+ T cells

TITLE: Towards improved immunocompetence of adoptively transferred CD8+ T cells


'"/>

Source:Journal of Clinical Investigation


Page: 1

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Columbia research lifts major hurdle to gene therapy for cancer
3. Combination therapy boosts effectiveness of telomere-directed cancer cell death
4. Gene therapy converts dead bone graft to new, living tissue
5. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
8. New therapy for HIV/AIDS eliminates needles and excessive toxicity
9. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
10. Gene therapy for Parkinsons disease moves forward in animals
11. Pulsating ultrasound enhances gene therapy for tumors
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Optimizing cell therapy against tumors balancing ACT

(Date:9/11/2014)... professor of mechanical engineering at Worcester Polytechnic ... university,s Integrative Materials Design Center (iMdc), has ... National Science Foundation (NSF) to support the ... metal-ceramic composites, which can be used to ... while significantly increasing their performance. , The ...
(Date:9/11/2014)... 11, 2014 UT Southwestern Medical Center, 2M Companies, ... research and drug development for neurodegenerative disorders caused by ... week, UT Southwestern researchers published a new paper about ... has been shown to help in various animal models ... to Dallas-based 2M Companies. 2M and Calico have now ...
(Date:9/11/2014)... In a study that sheds light on the ... of South America, LSU Museum of Natural Science Director ... Biological Sciences, Robb Brumfield, and an international team of ... published a paper this week challenging the view that ... formed is directly linked to geological and climatic ...
Breaking Biology News(10 mins):NSF funds new method for making materials that can make lighter, more efficient vehicles 2NSF funds new method for making materials that can make lighter, more efficient vehicles 3Calico enters into exclusive collaboration with 2M to develop UTSW technology 2Calico enters into exclusive collaboration with 2M to develop UTSW technology 3LSU scientists lead research on speciation in the tropics 2
... Ivaska (University of Turku and VTT Technical Research Centre of ... National Institute for Health and Welfare) have discovered that the ... a leading journal, the study concludes that SHARPIN regulates the ... prostate cancer cells. It is likely that the discovery will ...
... risk of extinction is a complicated task, especially for species ... University of Georgia and Tulane University have developed a mathematical ... appears in the early online edition of the Royal Society ... for a lot of species, we don,t know very much ...
... might lead to the development of better intervention methods, according ... published in the journal Substance Use & Misuse ... prompted college students to recall their smoking experience, and that ... and on weekends. "Students are using social events ...
Cached Biology News:New model more accurately describes migratory animals' extinction risk 2Research reveals when and why students smoke in effort to help them quit 2
(Date:9/11/2014)... Frederick, MD (PRWEB) September 12, 2014 ... systems (LIMS), radio-frequency identification (RFID) solutions and sample ... version 5.1. , RURO completed work on the ... late August and it has already seen mass ... recent major release of version 5.0 brought an ...
(Date:9/11/2014)... team of Berkeley Lab researchers believes it has ... of single atomic layers of transition metal dichalcogenide ... promise for nanoelectronic and photonic applications. , ... of tungsten disulfide, one of the most promising ... existence of excitonic dark states energy states ...
(Date:9/11/2014)... surface of graphene, a one atom thick sheet of ... graphene oxide; a form of graphene that could have ... industries. Applied as paint, it could provide an ultra-strong, ... , Graphene oxide solutions can be used to ... even conventional bricks. After a simple chemical treatment, the ...
(Date:9/11/2014)... Sept. 11, 2014 XBiotech announced today it ... machine that the Company says will be used to ... system is designed to fill, stopper and crimp vials, ... Additionally, the unit is said to contain an in-line ... provide a high level of quality compared to less ...
Breaking Biology Technology:Limfinity® Version 5.1 Available 2Excitonic dark states shed light on TMDC atomic layers 2Excitonic dark states shed light on TMDC atomic layers 3Graphene paints a corrosion-free future 2
... Press Ganey Associates, Inc. has announced its elite class ... the first-ever Summit and Top Improver awards for clinical ... Medical Centers. Press Ganey, the health ... more than 10,000 health care organizations worldwide to create ...
... Calif., Nov. 15, 2011 Quest Diagnostics Incorporated (NYSE: ... diagnostic testing, information and services, today announced that its ... Cytomegalovirus (CMV) molecular test kit on the 3M™ Integrated ... The test is designed to enable hospital labs to ...
... AURORA, Colo., Nov. 15, 2011 In a strategic ... Redevelopment Authority (FRA) has completed a regimen of planning ... allocation of resources going forward. The announcement is made ... "Our first tactic in refocus involves augmenting our board ...
Cached Biology Technology:Nation's Best Health Care Organizations for Patient Satisfaction, Core Measures Honored by Press Ganey 2Nation's Best Health Care Organizations for Patient Satisfaction, Core Measures Honored by Press Ganey 3Quest Diagnostics CE Marks Simplexa™ Test for Cytomegalovirus for Sale in Europe 2Quest Diagnostics CE Marks Simplexa™ Test for Cytomegalovirus for Sale in Europe 3Fitzsimons Redevelopment Authority Rolls Out First Phase of Strategic Refocus With Appointment of Four Key Leaders in The Bioscience Industry to Its Board of Directors 2
... Zyagen tissue microarrays are derived from ... to rigorous quality control procedures to ensure ... are manually assembled in one block, sectioned ... mounted on coated slides. Sections are large ...
... Zyagen tissue microarrays are derived from frozen ... rigorous quality control procedures to ensure the ... manually assembled in one block, sectioned at ... coated slides. Sections are large (3-5mm in ...
... The DNA Engine Opticon real-time PCR detection ... for fluorescence excitation (450-495 nm) and a ... The Opticon system is built on an ... a thermal gradient feature. This item includes ...
... for Optimal Microdissection , CapSure HS and ... and rapid extraction of populations of pure ... with Laser Capture Microdissection., Ensure the ... Analysis , All CapSure LCM Caps have ...
Biology Products: