Navigation Links
Opposing fat metabolism pathways triggered by a single gene

Regulating metabolism of fat is an important challenge for any animal, from nematodes to humans. Central players in the regulatory network are the nuclear hormone receptors (NHRs), which are transcription factors that turn on or off a set of target genes when bound by specific lipid molecules. In the premier open-access journal PLoS Biology, Keith Yamamoto and colleagues show that the nuclear hormone receptor nhr-49 controls two different aspects of fat metabolism, which interact to form a feedback system controlling the consumption and composition of fats in the nematode.

Using RNAi to suppress gene expression, the researchers discovered that when nhr-49 was absent, the lifespan of the nematode was reduced by more than 50%, and the animal displayed numerous gross abnormalities in the gut and gonad. This was accompanied by unusually high fat content in the larvae. They further showed that deletion of nhr-49 changed expression of 13 genes related to fat and glucose metabolism, with the most dramatic effects occurring within two metabolic pathways: mitochondrial lipid oxidation and fatty acid desaturation.

Following up on these changes in gene expression, Yamamoto and colleagues show that in its normal actions, nhr-49 sets in motion two opposing pathways: it increases expression of a gene acs-2, which leads to reduction of fat content, and it increases expression of another gene fat-7, which, by reducing acs-2, increases fat content. In its function, nhr-49 resembles a mammalian NHR, called peroxisome proliferator-activated receptors (PPARs). Further investigation of this link may lead to better understanding of the functions of PPARs and provide opportunities for altering their function for treatment of fat metabolism disorders such as diabetes and obesity.

###

Citation: Van Gilst MR, Hadjivassiliou H, Jolly A, Yamamoto K (2005) Nuclear hormone receptor nhr-49 controls fat consumption and fatty acid composition in C. elegans. PLoS Biol 3(2): e53.


'"/>

Source:PLoS


Related biology news :

1. Attacks of King George IIIs madness linked to key metabolism molecule
2. Computational model simulates AZT metabolism in mitochondria
3. Researchers attack tumor cells by exploiting dependency on sugar metabolism
4. Huddling and a drop in metabolism allow penguins to survive the South Pole cold
5. Primitive yeast yields secrets of human cholesterol and drug metabolism
6. Scientists identify genetic pathways essential to RNA interference
7. Scientists identify genetic pathways essential to RNA interference
8. New pathways for autoimmune treatment identified
9. New study reveals signaling pathways required for expansion of pancreas stem cells
10. Electronic chip, interacting with the brain, modifies pathways for controlling movement
11. Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/2/2020)... Calif. (PRWEB) , ... July 01, 2020 , ... ... company, presented its phase 1a findings of Neihulizumab, a biologic for the treatment ... in June 2020. Led by hemato-oncologist Dr. Paul J Martin of the Fred ...
(Date:6/28/2020)... ... ... In an upcoming episode scheduled for the fall of 2020, Advancements with Ted ... local listings for more info. , Today, the majority of testing is performed at ... the country. Results are then available several days later. Now, in an effort to ...
(Date:6/23/2020)... ... June 23, 2020 , ... Rigaku ... the next event in a series of TOPIQ webinars, which will cover the ... webinars was developed in response to social distancing measures that resulted in postponements ...
Breaking Biology News(10 mins):
(Date:8/7/2020)... Texas (PRWEB) , ... August 06, 2020 , ... ... and DNA vaccine industries, announces it has closed on the purchase of greenfield ... Park in Conroe, TX and includes over 21 acres in the initial acquisition, ...
(Date:7/31/2020)... ... 29, 2020 , ... Diversified Technologies, Inc. has introduced a ... to drive Klystrons, TWTs, IOTs, and magnetrons. , DTI Radar Transmitter Systems ... a push-pull configuration; yielding fast fall time for a capacitive load. These all ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... today announced the release of its signature product called Beacon - a ... and other field medical professionals. , Beacon helps MSLs streamline communication ...
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra , a leading ... food industries, is pleased to announce that Charles Galea has joined its clinical ... Charles is an accomplished and results-driven sales executive with over 10 years of ...
Breaking Biology Technology: