Navigation Links
Opposing fat metabolism pathways triggered by a single gene

Regulating metabolism of fat is an important challenge for any animal, from nematodes to humans. Central players in the regulatory network are the nuclear hormone receptors (NHRs), which are transcription factors that turn on or off a set of target genes when bound by specific lipid molecules. In the premier open-access journal PLoS Biology, Keith Yamamoto and colleagues show that the nuclear hormone receptor nhr-49 controls two different aspects of fat metabolism, which interact to form a feedback system controlling the consumption and composition of fats in the nematode.

Using RNAi to suppress gene expression, the researchers discovered that when nhr-49 was absent, the lifespan of the nematode was reduced by more than 50%, and the animal displayed numerous gross abnormalities in the gut and gonad. This was accompanied by unusually high fat content in the larvae. They further showed that deletion of nhr-49 changed expression of 13 genes related to fat and glucose metabolism, with the most dramatic effects occurring within two metabolic pathways: mitochondrial lipid oxidation and fatty acid desaturation.

Following up on these changes in gene expression, Yamamoto and colleagues show that in its normal actions, nhr-49 sets in motion two opposing pathways: it increases expression of a gene acs-2, which leads to reduction of fat content, and it increases expression of another gene fat-7, which, by reducing acs-2, increases fat content. In its function, nhr-49 resembles a mammalian NHR, called peroxisome proliferator-activated receptors (PPARs). Further investigation of this link may lead to better understanding of the functions of PPARs and provide opportunities for altering their function for treatment of fat metabolism disorders such as diabetes and obesity.

###

Citation: Van Gilst MR, Hadjivassiliou H, Jolly A, Yamamoto K (2005) Nuclear hormone receptor nhr-49 controls fat consumption and fatty acid composition in C. elegans. PLoS Biol 3(2): e53.


'"/>

Source:PLoS


Related biology news :

1. Attacks of King George IIIs madness linked to key metabolism molecule
2. Computational model simulates AZT metabolism in mitochondria
3. Researchers attack tumor cells by exploiting dependency on sugar metabolism
4. Huddling and a drop in metabolism allow penguins to survive the South Pole cold
5. Primitive yeast yields secrets of human cholesterol and drug metabolism
6. Scientists identify genetic pathways essential to RNA interference
7. Scientists identify genetic pathways essential to RNA interference
8. New pathways for autoimmune treatment identified
9. New study reveals signaling pathways required for expansion of pancreas stem cells
10. Electronic chip, interacting with the brain, modifies pathways for controlling movement
11. Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/9/2016)... 9, 2016  Perkotek an innovation leader in attendance control systems is proud to ... hours, for employers to make sure the right employees are actually signing in, and ... ... ... ...
(Date:6/7/2016)... -- Syngrafii Inc. and San Antonio Credit Union (SACU) ... Syngrafii,s patented LongPen™ eSignature "Wet" solution into SACU,s ... in greater convenience for SACU members and operational ... document workflow and compliance requirements. Logo ... Highlights: ...
(Date:6/2/2016)... 2016 The Department of Transport Management ... 44 million US Dollar project, for the , ... Personalization, Enrolment, and IT Infrastructure , to ... and implementation of Identity Management Solutions. Numerous renowned international vendors ... Decatur was selected for the most compliant and ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... LOUISVILLE, Ky. , June 23, 2016 /PRNewswire/ ... from two Phase 1 clinical trials of its ... double-blind, placebo-controlled, single and multiple ascending dose studies ... and pharmacodynamics (PD) of subcutaneous injection in healthy ... APL-2 subcutaneously (SC) either as a single dose ...
(Date:6/23/2016)... 2016 Andrew D ... http://doi.org/10.17925/OHR.2016.12.01.22 Published recently in ... from touchONCOLOGY, Andrew D Zelenetz , discusses ... care is placing an increasing burden on healthcare ... therapies. With the patents on many biologics expiring, ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... exhibiting at the Pennsylvania Convention Center and will showcase its product’s latest features ... will also be presenting a scientific poster on Disrupting Clinical Trials in The ...
(Date:6/23/2016)... Connecticut (PRWEB) , ... June 23, 2016 , ... ... introduce a new line of intelligent tools designed, tuned and optimized exclusively for ... September 12–17 in Chicago. The result of a collaboration among several companies with ...
Breaking Biology Technology: