Navigation Links
One therapeutic dose of radiation causes 30 percent spongy bone loss in mice

l cancer increased the risk of fracture by 200%, he said.

Astronauts lose 2% of bone mass for each month they are exposed to the effects of microgravity. So far, astronauts have not been exposed to the increased radiation of outer space, but that will change when they undertake a proposed 30-month trip to Mars, Bateman said. NASA has focused on radiation's cancer-causing properties and its ability to compromise the central nervous and immune systems. But the effect on bone health is an unexamined concern.

The murine (mouse) model such as the one in this study provides a way to study the physiological effects of radiation using controlled experiments. Clinical studies of people who undergo radiation to treat cancer are limited because of the complicating factors of the illness itself and the chemotherapy which often accompanies it. "You can't study this in people, so having a well-defined animal model is important," Bateman said.

Study focuses on four types of radiation

In the current study, the mice received a single 2 Gray (Gy) dose, which is comparable to the single dose of 1-2 Gy that human cancer patients receive. However, cancer patients receive a series of doses over the course of therapy, totaling 10-70 Gy. (The amount of radiation in a Gy varies, because it is calculated based on the recipient's weight.)

The mice were divided into five groups. The control group received no radiation. Each of the remaining four groups received a different type of radiation: gamma, proton, ion or carbon. Those exposed to the carbon radiation suffered 39% spongy bone loss; proton, 35%; ion, 34%; and gamma, 29%. The loss of spongy connections in the four groups ranged from 46-64%, he said.

Cancer patients typically receive either gamma or, less commonly, proton radiation. Astronauts on a Mars mission are expected to receive extended periods of low-dose radiation of multiple types, including protons and heavy ions, Bate
'"/>

Source:American Physiological Society


Page: 1 2 3

Related biology news :

1. Study reveals candidate targets for anti-retroviral therapeutics
2. Tetanus toxin found to have therapeutic properties
3. Dendritic cells offer new therapeutic target for drugs to treat MS and other autoimmune disease
4. Greasing interferons gears may pave way to greater therapeutic benefits, fewer side effects
5. Anthrax inhibitor counteracts toxin, may lead to new therapeutics
6. Nano-particles effective in killing cancer with one-two punch of chemotherapeutics
7. T cells activated to fight HIV basis for dendritic cell therapeutic vaccine
8. Small molecule dervived from Rb2/p130 could act as cancer therapeutic
9. Gene therapy may protect normal tissues during radiation retreatment for lung cancer
10. Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
11. Gene therapy protects mice from the effects of whole-body irradiation
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: One therapeutic dose radiation causes percent spongy bone loss mice

(Date:7/10/2014)... in New Mexico, nearly every public golf course is ... potable water supplies. Across the U.S. Southwest as a ... treated effluent. Reusing the effluent increases the sustainability of ... alike fertilize their lawns during the growing season. The ... State University turfgrass expert has a new vision for ...
(Date:7/10/2014)... Mass. , June 30, 2014  Aware, Inc. ... biometrics software and services, previously announced on June 26, ... special cash dividend of $1.75 per share, or approximately ... date of July 10, 2014 and a payment date ... by NASDAQ that it had set an ex-dividend date ...
(Date:7/10/2014)... N.Y. , July 2, 2014 It ... (ABD) to announce the appointment of the world-renowned Thoracic ... Board of Directors. Dr. Ginsburg, with over ... facilities: NY Presbyterian Hospital and Good Samaritan Regional Medical ... Pacemaker since the late 1980,s and is considered an ...
Breaking Biology News(10 mins):'Tailored' water -- the latest in lawn care 2NASDAQ Sets Ex-Dividend Date for Aware, Inc.'s Special Cash Dividend of $1.75 Per Share 2Avery Biomedical Devices, Inc. announces the appointment of Mark E Ginsburg, M.D. to its Board of Directors 2
... There are potentially effective treatments for acute myeloid leukemia ... of cases. In a paper published today in Leukemia ... has pinpointed a protein that could play a key, previously ... new information in the quest to treat and cure childhood ...
... Complex heritable traits are not only determined by changes ... Groningen Bioinformatics Centre, together with their French colleagues, have ... flowering time and architecture in plants. Furthermore, these marks ... manner. Their results were published in Science ...
... will be equipped with a new, online information system ... disorders, thanks to 3.5m European Union funding for EMBalance. ... involve researchers from ten different partners, spread across seven ... dizziness etc.) affect more than a third of the ...
Cached Biology News:New target isolated for leukemia drug development 2Revolutionary new view on heritability in plants 2Revolutionary new view on heritability in plants 3€3.5m to improve diagnosis of balance disorders 2
(Date:7/10/2014)... Terascala, the industry leader in ... a former vice president of product management for Flexera ... of marketing. Terascala’s software when combined with leading compute ... highest performance and most reliable solutions for processing big ... channel expansion and broaden its product portfolio. His leadership ...
(Date:7/10/2014)... 2014 Senior supply chain management executives ... addressed the challenges of “Reducing Cost, Lead Time, & ... strategic sourcing. Describing the partnership of the Bio Supply ... Management Institute ( SCMI) of the University of ... at the Kroc Institute of Peace and Justice in ...
(Date:7/10/2014)... , July 10, 2014 Research and ... of the "International Photonic Integrated Circuit (Monolithic ... to 2019" report to their offering. ... The concept of photonic integration traces its roots ... The promise of photonic integration went unexplored and ...
(Date:7/10/2014)... the journal PNAS (Proceedings of the National Academy ... and sleep deprivation have a significant effect on our ... the best time of day to test for diseases ... medicines effectively. , Researchers from the University of Surrey ... links between sleep deprivation, body clock disruption and metabolism, ...
Breaking Biology Technology:Terascala Expands Executive Team 2Terascala Expands Executive Team 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Time of day crucial to accurately test for diseases, new research finds 2
... Accounting Oversight Board (PCAOB) will place a greater ... numerous studies, including our own, that show IT change ... the investment to fix your change management process because ... compliance program. , ,PCAOB Release number 2006-007, a ...
... Wis. - Perscitus Biosciences, a Madison biotechnology company, ... Department of Commerce . , ,Perscitus Biosciences was ... based on reactive oxygen biochemistry. James Thomas, CEO and ... be used to purchase equipment and hire researchers to ...
... what many deemed a historic meeting between Steve Jobs ... Wall Street Journal's schmooze-fest titled D: All Things Digital. While ... Age were cordial and humble (a word I have not often ... of competition and cooperation in the most mutually complimentary terms (you ...
Cached Biology Technology:Why IT change management is more important than ever 2Why IT change management is more important than ever 3Why IT change management is more important than ever 4What if Jobs and Gates had teamed up? 2What if Jobs and Gates had teamed up? 3What if Jobs and Gates had teamed up? 4
... Disruption of the mitochondrial transmembrane potential ... events that occur following induction of ... Kit utilizes a lipophilic cation, termed ... marker. MitoLight is a mitochondrial dye ...
... Detection Kit contains a green fluorescent-labeled inhibitor, ... of valylalanylaspartic acid (VAD) fluoromethyl ketone (FMK), ... When added to a population of cells, ... and covalently binds to a reactive cysteine ...
... ChipWriter Pro system, 220-240 V, uses floating ... oligonucleotides, carbohydrates, lipids, and other biomolecules onto ... This system can generate high-density arrays with ... or greater than 57,000 spots per membrane ...
... arrays have been developed for affinity ... A variety of ProteinChip chemical surfaces ... to their unique biochemical properties. Each ... side-by-side sample comparison, and the chips ...
Biology Products: