Navigation Links
One therapeutic dose of radiation causes 30 percent spongy bone loss in mice

Mice receiving just one therapeutic dose of radiation lost up to 39% of the spongy portion of their inner bone, reducing the inner bone's weight bearing connections by up to 64%, researchers reported. The study, which appears in the online edition of the Journal of Applied Physiology, has implications for patients receiving radiation therapy and astronauts traveling on long space flights.

"We were really surprised at the extent of bone loss," said lead researcher Ted A. Bateman of Clemson University. "We're seeing bone loss at much lower doses of radiation than we expected." The mice suffered the loss of trabecular bone, the spongy area of bone inside the dense outer area known as the cortical bone.

"It's interesting that the trabecular bone, not the cortical bone, suffered the damage," said Bateman, a bioengineer who studies bone biomechanics. The remaining spongy bone must redistribute the load to bear the weight, but this makes the bone support structure less efficient and leaves the bone more vulnerable to fracture.

"A murine model for bone loss from therapeutic and space-relevant sources of radiation," by Sarah A. Hamilton, Neil D. Travis, Jeffrey S. Willey, Eric R. Bandstra and Ted A. Bateman, Clemson University; and Michael J. Pecaut, Daila S. Gridley and Gregory A. Nelson, Loma Linda University and Medical Center, appears in the online edition of the Journal of Applied Physiology, published by The American Physiological Society.

Mouse model applies to humans

The results of a mouse study cannot be directly applied to humans. However, both mice and humans lose bone after radiation exposure, so the results raise a red flag. Bateman noted that a recent clinical study of 6,000 cancer patients reported in the Journal of the American Medical Association found that post-menopausal women who received pelvic radiation for cervical and colorectal cancer increased their bone fracture risk by 60%. Radiation following ana
'"/>

Source:American Physiological Society


Page: 1 2 3

Related biology news :

1. Study reveals candidate targets for anti-retroviral therapeutics
2. Tetanus toxin found to have therapeutic properties
3. Dendritic cells offer new therapeutic target for drugs to treat MS and other autoimmune disease
4. Greasing interferons gears may pave way to greater therapeutic benefits, fewer side effects
5. Anthrax inhibitor counteracts toxin, may lead to new therapeutics
6. Nano-particles effective in killing cancer with one-two punch of chemotherapeutics
7. T cells activated to fight HIV basis for dendritic cell therapeutic vaccine
8. Small molecule dervived from Rb2/p130 could act as cancer therapeutic
9. Gene therapy may protect normal tissues during radiation retreatment for lung cancer
10. Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
11. Gene therapy protects mice from the effects of whole-body irradiation
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: One therapeutic dose radiation causes percent spongy bone loss mice

(Date:7/24/2014)... SAN DIEGO , July 24, 2014 /PRNewswire-iReach/ -- ... managing data from cardiac devices, has cut emergency room ... the UC San Diego (UCSD) Medical Center, according to ... Journal. The UCSD Emergency Departments are using the suite ... such as pacemakers or defibrillators. "Using Geneva,s ...
(Date:7/24/2014)... for food or commercial food sale, has been heavily ... of many species of primates and other mammals. ... of the species being consumed are birds, particularly large ... the meat made available for sale but the meat ... and brought to villages for consumption, we noted a ...
(Date:7/24/2014)... different effects on different species of fish, according ... Bristol and Exeter which tested fish anti-predator behaviour. ... flying seagull predator model when exposed to additional ... minnows. , Lead author Dr Irene Voellmy ... levels in many aquatic environments have increased substantially ...
Breaking Biology News(10 mins):UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 2UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 3
... documents dating back 3,500 years say they have found ... ancient Egypt and not with Hippocrates and the Greeks. ... Biomedical Egyptology at The University of Manchester discovered the ... before Hippocrates was born. , "Classical scholars have ...
... and Gail Williams and Stockholm University's Professor Robin Room examined ... and 2002. , Their results were published in the ... Review. , The men were categorised according to ... is a marker for lower socio-economic status (SES). ...
... Investigator, and Nancy Bae, Ph.D., Postdoctoral Research Associate ... offering insight into the way cells protect chromosome ... tomorrow's issue of Molecular Cell, their paper entitled ... Human Telomeric DNA Ends" employed a biochemical assay ...
Cached Biology News:Egyptians, not Greeks were true fathers of medicine 2Double the death rate from cirrhosis for 'blue collar' men 2Baumann Lab defines proteins that distinguish chromosome ends from DNA double-strand breaks 2
(Date:7/24/2014)... 24, 2014 SRI International has been awarded ... Institute of Allergy and Infectious Diseases (NIAID), part of ... of potential therapies for HIV infection and AIDS. The ... and AIDS and the complications and opportunistic infections associated ... sexual transmission of HIV. According to ...
(Date:7/24/2014)... Texas (PRWEB) July 24, 2014 ... Potassium Sulphate Industry” is a professional and in-depth ... report introduces Potassium Sulphate basic information, including ... and industry overview. This research covers the international ... as global industry analysis covering macroeconomic environment & ...
(Date:7/24/2014)... July 24, 2014 1000 balances – ... input on customers’ weighing needs and expertly narrows down ... of balances, scales or even terminals. , First, ... smallest weight (or select readability instead) and define the ... additional selection criteria narrows down the list to models ...
(Date:7/24/2014)... , July 24, 2014  Spherix Incorporated (SPEX) -- ... and monetization of intellectual property, today announced that the ... ending June 30, 2014 on Monday, August 18, 2014 ... 10 a.m. ET on Monday, August 18, 2014 to ... by the company,s CEO, Anthony Hayes . ...
Breaking Biology Technology:National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 4Spherix Schedules Shareholder Update Call 2
... and biotech,companies are drawing on Singapore,s integrated network ... productivity, leverage academic,insights and diversify risks. Located at ... is representative of key Asian ethnic groups, Singapore ... and develop new solutions for,Asia and beyond. , ...
... an agreement-in-principle to ensure the valorization and the operation under ... Faculty of veterinary medicine in St-Hyacinthe, Quebec, Canada, for human ... ... Laval, Quebec (PRWEB) May 18, 2009 -- Universite de Montreal ...
... Simcere Pharmaceutical Group,("Simcere" or the "Company") (NYSE: SCR ... pharmaceuticals in China, today reported,unaudited financial results for the quarter ... -- Total revenue increased to RMB442.5 million ... first quarter of 2009 from RMB394.6 million for the corresponding, ...
Cached Biology Technology:Pharma and Biotech Companies Plug into Singapore's Integrated Research Network 2Pharma and Biotech Companies Plug into Singapore's Integrated Research Network 3Pharma and Biotech Companies Plug into Singapore's Integrated Research Network 4Pharma and Biotech Companies Plug into Singapore's Integrated Research Network 5Simcere Pharmaceutical Group Reports Unaudited First Quarter 2009 Results 2Simcere Pharmaceutical Group Reports Unaudited First Quarter 2009 Results 3Simcere Pharmaceutical Group Reports Unaudited First Quarter 2009 Results 4Simcere Pharmaceutical Group Reports Unaudited First Quarter 2009 Results 5Simcere Pharmaceutical Group Reports Unaudited First Quarter 2009 Results 6Simcere Pharmaceutical Group Reports Unaudited First Quarter 2009 Results 7Simcere Pharmaceutical Group Reports Unaudited First Quarter 2009 Results 8Simcere Pharmaceutical Group Reports Unaudited First Quarter 2009 Results 9Simcere Pharmaceutical Group Reports Unaudited First Quarter 2009 Results 10Simcere Pharmaceutical Group Reports Unaudited First Quarter 2009 Results 11
Immunogen: Synthetic peptide (aa sequence is considered to be commercially sensitive) Storage: -20 C, Avoid Freeze/Thaw Cycles...
... Clone/PAD: ZMD.467. Immunogen: Synthetic ... of the human rat mouse dog ... Specific for the human occludin protein. ... cell lysates). Reactivity with rat ...
...
... Biochain's plant total protein ... for rapidly screening tissue specific ... Human placenta total protein is ... an interblot control for comparison ...
Biology Products: