Navigation Links
One therapeutic dose of radiation causes 30 percent spongy bone loss in mice

Mice receiving just one therapeutic dose of radiation lost up to 39% of the spongy portion of their inner bone, reducing the inner bone's weight bearing connections by up to 64%, researchers reported. The study, which appears in the online edition of the Journal of Applied Physiology, has implications for patients receiving radiation therapy and astronauts traveling on long space flights.

"We were really surprised at the extent of bone loss," said lead researcher Ted A. Bateman of Clemson University. "We're seeing bone loss at much lower doses of radiation than we expected." The mice suffered the loss of trabecular bone, the spongy area of bone inside the dense outer area known as the cortical bone.

"It's interesting that the trabecular bone, not the cortical bone, suffered the damage," said Bateman, a bioengineer who studies bone biomechanics. The remaining spongy bone must redistribute the load to bear the weight, but this makes the bone support structure less efficient and leaves the bone more vulnerable to fracture.

"A murine model for bone loss from therapeutic and space-relevant sources of radiation," by Sarah A. Hamilton, Neil D. Travis, Jeffrey S. Willey, Eric R. Bandstra and Ted A. Bateman, Clemson University; and Michael J. Pecaut, Daila S. Gridley and Gregory A. Nelson, Loma Linda University and Medical Center, appears in the online edition of the Journal of Applied Physiology, published by The American Physiological Society.

Mouse model applies to humans

The results of a mouse study cannot be directly applied to humans. However, both mice and humans lose bone after radiation exposure, so the results raise a red flag. Bateman noted that a recent clinical study of 6,000 cancer patients reported in the Journal of the American Medical Association found that post-menopausal women who received pelvic radiation for cervical and colorectal cancer increased their bone fracture risk by 60%. Radiation following ana
'"/>

Source:American Physiological Society


Page: 1 2 3

Related biology news :

1. Study reveals candidate targets for anti-retroviral therapeutics
2. Tetanus toxin found to have therapeutic properties
3. Dendritic cells offer new therapeutic target for drugs to treat MS and other autoimmune disease
4. Greasing interferons gears may pave way to greater therapeutic benefits, fewer side effects
5. Anthrax inhibitor counteracts toxin, may lead to new therapeutics
6. Nano-particles effective in killing cancer with one-two punch of chemotherapeutics
7. T cells activated to fight HIV basis for dendritic cell therapeutic vaccine
8. Small molecule dervived from Rb2/p130 could act as cancer therapeutic
9. Gene therapy may protect normal tissues during radiation retreatment for lung cancer
10. Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
11. Gene therapy protects mice from the effects of whole-body irradiation
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: One therapeutic dose radiation causes percent spongy bone loss mice

(Date:7/23/2015)... 23, 2015 Aware, Inc. (NASDAQ: AWRE ), ... financial results for its second quarter ended June 30, 2015.  ... was $4.5 million, a decrease of 33% compared to $6.8 ... the second quarter of 2015 was $0.3 million, or $0.01 ... per diluted share, in the same period a year ago.  ...
(Date:7/21/2015)... July 21, 2015 Passwords have proven ... in the recent U.S. Office of Personnel Management ... the infosec conundrum, but developers and end-users are ... address this dilemma, Biometrics-as-a-Service provider HYPR Corp. announced ... SDK for third party integration. ...
(Date:7/9/2015)... , July 9, 2015  Synaptics Inc. (NASDAQ: ... announced today that it will report financial results for ... July 30, 2015 after the close of market. The ... and investors at 2:00 p.m. PT (5:00 p.m. ET), ... To participate on the live call, analysts and ...
Breaking Biology News(10 mins):Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2
... providing living cells with energy, to nitrogen fixation, to ... metalloenzymes proteins that contain a metal ion ... of the chemistry behind these catalytic activities could pave ... photosynthesis systems that would provide clean, green and ...
... of the motor that propels archaea has been characterized ... from the U.S. Department of Energy,s Lawrence Berkeley National ... for Terrestrial Microbiology. The motility structure of ... a flagellum, a whip-like filament that, like the well-studied ...
... new study has linked exposure to two common perfluorinated ... than 200 industrial processes and consumer products including certain ... care products, and other items. Because of their persistence, ... The study, published in Environmental Health Perspectives , ...
Cached Biology News:A dual look at photosystem II using the world's most powerful X-ray laser 2A dual look at photosystem II using the world's most powerful X-ray laser 3Revealing the secrets of motility in archaea 2Revealing the secrets of motility in archaea 3Revealing the secrets of motility in archaea 4Revealing the secrets of motility in archaea 5Yale Study links common chemicals to osteoarthritis 2
(Date:7/30/2015)... 30, 2015   Senomyx , Inc. (NASDAQ: ... technologies to discover, develop, and commercialize novel flavor ingredients ... reported financial results for the second quarter 2015. ... we remain on track to achieve our commercial and ... Officer of the Company. "Since our last quarterly earnings ...
(Date:7/30/2015)... 30, 2015 Ascendis Pharma A/S (Nasdaq: ... its innovative TransCon technology to address significant unmet ... a six-month Phase 2 study to evaluate the ... in 53 treatment-naïve, pre-pubertal children with growth hormone ... pleased with the top-line results from our Phase ...
(Date:7/30/2015)... 30, 2015  Discovery Laboratories, Inc. (Nasdaq: ... the second $1.0M tranche under a previously awarded ... valued at up to $3.0 million to support ... as a potential medical countermeasure to mitigate acute ... awarded an initial $1.0 million under this grant ...
(Date:7/30/2015)... NH (PRWEB) , ... July 30, 2015 , ... ... homogenizer for advanced fluid applications and designed for continuous operation up to 1500 ... and sterilization-in-place, ensuring safety, efficiency, and preventing toxic contamination. , The Pony™ NS2006L ...
Breaking Biology Technology:SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 2SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 3SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 4SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 5SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 6SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 7SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 8SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 9Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 5Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 6Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 7Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3GEA Announces the Pony™ NS2006L… a Self-contained, High Pressure Lab Homogenizer for Product Development Ensuring Maximum Efficiency and Safety 2
... Awards Celebration has show of ... supporters, gains momentum, ... drive Pennsylvania,s economic future, finding an advantage amidst global,competition requires ... Celebration, Nov. 8-9, does just,that, and will help secure that ...
... To Regain Hearing in Both Ears for the First ... ... the world,s leader in,advanced hearing technologies, today announced a landmark milestone ... the,120,000th cochlear implant device procedure. Today, 72-year-old New York,resident, Susan Grossman, ...
... SIGG and Recommends Greener Bottle , ... Concord, NH (PRWEB) July 25, ... or Madonna, they,re probably sipping water from a SIGG bottle. "Carrying a ... may not be that green," said Debby de Moulpied, founder and owner ...
Cached Biology Technology:Conference to Turn Scientists of Color into PA-Based Entrepreneurs Set for November 2Conference to Turn Scientists of Color into PA-Based Entrepreneurs Set for November 3Cochlear Announces Milestone in Hearing Restoration With 120,000 Nucleus(R) Cochlear Implants 2Cochlear Announces Milestone in Hearing Restoration With 120,000 Nucleus(R) Cochlear Implants 3Cochlear Announces Milestone in Hearing Restoration With 120,000 Nucleus(R) Cochlear Implants 4SIGG Water Bottles: Hip But Not Necessarily Green; Were Madonna and Cindy Crawford Hoodwinked? 2
Goat polyclonal to STMN2 ( Abpromise for all tested applications). Antigen: Synthetic peptide: AKTAMAYKEK, corresponding to C terminal amino acids 2-11 of STMN2. Entrez Gene ID: 11075 Swi...
Anti-Human alpha2-Antiplasmin Purified (Polyclonal) (goat IgG)...
... proud to work in collaboration with Pall ... syringe filters in a variety of membrane ... for use on the Caliper TPWII, MultiDose, ... Pricing for our Automation Certified Syringe Filters ...
... TATA Binding Proteins (TBP). Ascites Antibody ITBP20 ... recognizes amino acids 41-57 and may be ... TBP occurs. This antibody does not ... as a nuclear extract or as a ...
Biology Products: