Navigation Links
One signal elicits thousands of answers

of all proteins in living cells - and in their temporal dynamic. For this approach cell cultures were stimulated by EGF for different lengths of time. The "Epidermal Growth Factor" is known for causing the phosphorylation of a multitude of enzymes and proteins along a signal transduction pathway. In the following step all proteins were isolated from the cells, divided into different fractions and analysed via mass spectrometry. This technology allows the precise identification of structure and composition of unknown compounds, here the cellular proteins. In total, 6,600 specific phosphorylation sites in 2,244 proteins were detected. "Comparing our results with the listings in existing databases showed that more than 90 percent of our sites were novel. This suggests that the majority of cellular phosphorylation sites still await identification."

Equally surprising was the discovery that about half of all cellular proteins harbour more than one phosphorylation sites, which in many cases behave differently. "This makes more than one way of phosphorylation possible where proteins serve as integrating platforms for a variety of incoming stimuli", says Mann. "This integration of signals could be independent, with phosphorylation of each site occurring separately from the others. It could also be dependent so that a 'priming site' has to be phosphorylated first for the subsequent modification of all other sites in the protein. In any case, the degree of phosphorylation should always be measured site specifically rather than for the protein as a whole". For the efficient use of their results the research team created the Phosida database (www.phosida.com), where all the phosphorylation sites are listed with additional information and connections to respective listings in other databases. An interesting service for scientists with widely varying expertise, not the least for tumour researchers because they have to investigate def
'"/>

Source:Max-Planck-Gesellschaft


Page: 1 2 3

Related biology news :

1. Plants respond similarly to signals from friends, enemies
2. Bound for destruction: Ubiquitination protects against improper Notch signaling
3. Viral protein influences key cell-signaling pathway
4. Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
5. Edible bivalves as a source of human pathogens: signals between vibrios and the bivalve host.
6. Scientists discover that three overlapping signals in embryo help get the backbone right
7. After a time-shift, mixed signals from the circadian clock
8. Researchers make surprise discovery that some neurons can transmit three signals at once
9. Structure-building cell signals also may influence learning and memory
10. Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage
11. Immune systems distress signal tells bacteria when to strike back
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: One signal elicits thousands answers

(Date:4/6/2015)... 6, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market, ... 62/143028 for MINIATURE, MULTI-PURPOSE ANTENNA METHOD AND ... NXT-ID introduces a new revolutionary method and ... the use of miniature antenna modules for multiple ...
(Date:4/2/2015)... -- Fingerprint Cards (FPC) has received an ... distributor World Peace Industrial Group (WPI), part of WPG ... major part of the shipments will take place during ... manufacturers in China . The order ... revenue guidance of + 1 000 MSEK for 2015.  ...
(Date:3/31/2015)...   Guidepoint , a leading global research services ... Management TRACKER, part of the Guidepoint TRACKER ... medical device and therapeutics markets. The Post-Surgical Pain Management ... market share, and adoption rates across three major modalities ... The Post-Surgical Pain Management TRACKER will provide ...
Breaking Biology News(10 mins):NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3
... EAC standard by providing ... single platform, DALLAS, Sept. 10 As ePassport ... many seek a method,to deploy border security capabilities in ... ENTU ) and 3M (NYSE: MMM ),announce a ...
... has been awarded $1 million from the US Department ... biomass conversion technologies. The grant is one of six ... develop their advanced biofuels projects. In total, the DOE ... projects for their research into how non-food feedstocks can ...
... of California White Mountain Research Station, U.S. Forest ... Integrated Climate Research in Western Mountains will host ... Tri-Valley Fairgrounds in Bishop. The conference is entitled ... will bring together distinguished researchers from a variety ...
Cached Biology News:Entrust, 3M Collaborate to Provide End-to-End Secure ePassport Solution 2Entrust, 3M Collaborate to Provide End-to-End Secure ePassport Solution 3Entrust, 3M Collaborate to Provide End-to-End Secure ePassport Solution 4Stevens awarded $1M for advanced biofuels research 2
(Date:4/30/2015)... , April 30, 2015 The following is an ... Directors of China Cord Blood Corp (NYSE: CO ) ... committee of the independent directors of China Cord Blood Corp ... offer of $6.40 per share from Golden Meditech Holdings Co ... per share would greatly benefit Golden Med and Mr. Kam, ...
(Date:4/30/2015)... SAN DIEGO , April 30, 2015 /PRNewswire/ ... company engaged in the development of biosimilar therapeutics ... today announced the closing of its previously announced ... common stock at a public offering price of ... full by the underwriters of their option to ...
(Date:4/30/2015)... -- WuXi PharmaTech (Cayman) Inc. ("WuXi" or the "Company") ... services provider, today announced that its board of directors ... 29, 2015, from a consortium (the "Consortium") led by ... and chief executive officer of the Company, and Ally ... (the "Transaction") involving the acquisition of all outstanding shares ...
(Date:4/30/2015)... SureClinical, a leader in cloud-based health science ... SureClinical’s executive team as Chief Financial Officer. ... with over 25 years in leadership roles ranging from ... Morris joins SureClinical from Marrone Bio Innovations (MBI), a ... MBI from its founding in 2006 until 2011, when ...
Breaking Biology Technology:April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 2April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 3April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 4April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 5Pfenex Inc. Announces Closing of Public Offering of Common Stock and Full Exercise of Underwriters' Option to Purchase Additional Shares 2WuXi PharmaTech Announces Receipt of Proposal 2WuXi PharmaTech Announces Receipt of Proposal 3WuXi PharmaTech Announces Receipt of Proposal 4WuXi PharmaTech Announces Receipt of Proposal 5WuXi PharmaTech Announces Receipt of Proposal 6Julie I. Morris Joins SureClinical as Chief Financial Officer 2
... Fla., Feb. 16, 2012   GeneLink Biosciences, ... company, has completed the sale of the stock ... Sciences, Inc. (GeneWize)  to Capsalus Corp. (OTCBB: WELL), ... wellness marketplace.  As previously disclosed, GeneLink and Capsalus ...
... 2012 /PRNewswire-iReach/ -- FirstMark today announced the ... cardiovascular blood test PREvent. These clinical results demonstrate the ... (2-3 years) risk of myocardial infarction and death in ... The clinical study and final data was well received ...
... today the publication of key results relating to its ... high-value G-protein-coupled receptor (GPCR) targets in Science . ... Lipid G Protein-Coupled Receptor," was co-authored by Receptos in ... Raymond Stevens, Ph.D. Drs. Rosen and Stevens are both ...
Cached Biology Technology:GeneLink Biosciences Completes Sale of GeneWize Life Sciences 2FirstMark's Landmark Clinical Study Successfully Completed that Fulfills the Unmet Need to Access the Risk of Near Term MI 2Receptos Scientists Publish Determination of a High Resolution Sphingosine 1-Phosphate Receptor 1 Structure in Science 2Receptos Scientists Publish Determination of a High Resolution Sphingosine 1-Phosphate Receptor 1 Structure in Science 3Receptos Scientists Publish Determination of a High Resolution Sphingosine 1-Phosphate Receptor 1 Structure in Science 4
... Collection of Cell Cultures (ECACC) has been ... academia and government institutes for over seven ... designed to introduce candidates to cell culture ... on more specialist areas such as planning ...
...
These 22x40mm rectangular No.1 Corning cover glasses are made from No. 0211 zinc titania glass and are 0.16 to 0.19mm thick. • Approx. Pcs Oz : 73...
...
Biology Products: