Navigation Links
Once given 'no respect,' cells' tiny RNAS take driver's seat

ls the gene for a set of six microRNAs in a region of chromosome 13 that is already tied to development of human lymphoma.

MicroRNAs are made by the same cellular machinery that makes other forms of RNA -- like the messenger RNA used to build proteins. However, microRNAs are immediately processed by cellular machinery that deals with what is known as RNA interference -- a biological phenomenon that specifically prevents RNA from being used to make proteins.

Accompanying the Hopkins paper are two reports looking specifically at microRNAs in cancer -- one in humans, one in mice. One report shows that human tumors' microRNA "fingerprints" -- patterns showing which of the more than 200 known microRNAs are more or less abundant than normal -- identify the tumors' tissue of origin much better than other tests. The other paper shows that over-expression of chromosome 13's microRNAs dramatically increases the risk of cancer in mice predisposed to cancer because of a faulty Myc gene.

"We've found that there's complex crosstalk between Myc, the microRNAs and the genes that both control," says Mendell. "This complex system, if disturbed, has the potential to very potently drive cell growth and cancerous proliferation."

Among the genes Myc controls is one called E2F1, which, like Myc, also controls the expression of genes. One of the genes controlled by E2F1 just happens to be the gene for Myc.

"This establishes a feedback loop," says Kathryn O'Donnell, Ph.D., who conducted much of the work as a graduate student in the Human Genetics Program. "Because both Myc and E2F1 increase the expression of genes that increase cell growth, the pair could be quite dangerous if they simply fed off each other."

But the researchers also discovered that two of the six microRNAs controlled by Myc actually reduce cells' ability to use E2F1's protein-building instructions. Essentially, these microRNAs act as a "brake" to slow E2F1's growth-promoting
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2 3

Related biology news :

1. Experimental vaccine protects nonhuman primates when given after exposure to Marburg virus
2. Fertility drugs given all-clear in new study
3. Experimental vaccine given during pregnancy reduces stillbirths from common virus
4. Two chemicals boost immune cells ability to fight HIV without gene therapy
5. How HIV disables the cells call for help
6. Stem cells electric abilities might help their safe clinical use
7. Scientists discover the molecular switch for nerve cells insulating jelly rolls
8. New insight into machinery of immune cells tentacles
9. Failure of scout cells may lead to cancer in transplant patients
10. Allergy cells can aggravate cancer and psoriasis
11. A key antibody, IgG, links cells capture and disposal of germs
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Once given respect cells tiny RNAS take driver seat

(Date:4/1/2015)... 1, 2015  NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market, announces the second ... is underway to early access pre-order customers. ... at retail outlets including Walmart, Target, AT&T, Dunkin, Donuts, ... was accepted at all outlets and very easy to ...
(Date:3/31/2015)... 2015  Elephant Talk Communications Corp. (NYSE MKT: ETAK) ... Software Defined Network Architecture (ET Software DNA® 2.0) platforms ... approximately $20.4 million for the year ended December 31, ... the year ended December 31, 2013. ... completed its multi-year transition away from its legacy landline ...
(Date:3/30/2015)... Research and Markets ( http://www.researchandmarkets.com/research/lc9bnl/global_gesture ) ... Recognition Market in Automotive Sector 2014-2018" report to ... Gesture Recognition market in Automotive Sector to grow at ... Gesture recognition is the ability of a device ... individual. Gesture recognition technology can be 2D-based or 3D-based. ...
Breaking Biology News(10 mins):NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2
... April 11, 2011 (BRONX, NY) Just as inhaling ... it. Two researchers at Albert Einstein College of Medicine ... grant from the National Institutes of Health to clinically develop ... before the cancer becomes malignant and spreads. The grant ...
... SEATTLE, Wash.April 12, 2011The Allen Institute for Brain ... genomically comprehensive human brain map, a previously unthinkable ... than four years of rigorous studies and documentation. ... Allen Human Brain Atlas, an online public resource ...
... material available to identify persons or find next of kin ... the kits usually employed to carry out DNA identifications do ... is not available, and that which is available is highly ... persons from these small fragments of DNA. His thesis, presented ...
Cached Biology News:NIH funds investigation of inhaled lung cancer treatment 2Allen Institute for Brain Science announces first comprehensive gene map of the human brain 2Allen Institute for Brain Science announces first comprehensive gene map of the human brain 3Developing a tool for identification -- even using very degraded DNA samples 2Developing a tool for identification -- even using very degraded DNA samples 3
(Date:5/4/2015)... May 4, 2015  Tikcro Technologies Ltd. (OTCQB: TIKRF) ... on Form 20-F for the fiscal year ended December ... ("SEC"). The annual report on Form 20-F contains information ... in the area of cancer immune checkpoints. This project ... high specificity and binding in targeting certain identified immune ...
(Date:5/4/2015)... May 4, 2015  Traverse Biosciences announced today ... and development agreement (CRADA) with Aratana Therapeutics Inc. ... of TRB-N0224 for the treatment and control of ... cats.  Traverse Biosciences has also granted Aratana an ... and control of periodontal disease in companion animals, ...
(Date:5/4/2015)... , May 4, 2015 /PRNewswire/ - Fluorinov ... to announce the appointment of Dr. Roger J ... experience guiding biotech companies in matters including corporate ... leadership team and adds significant regulatory expertise as ... Dr. Garceau brings 30 years of pharmaceutical development ...
(Date:5/4/2015)... 2015 /PRNewswire/ - The Fight Against Cancer Innovation ... announce the formation of Turnstone Biologics Inc. (Turnstone), ... cancer that harness the patient,s own immune system. ... between the Children,s Hospital of Eastern ... the Ontario Institute for Cancer Research (OICR), the ...
Breaking Biology Technology:Tikcro Technologies Files Annual Report on Form 20-F for the Year Ended December 31, 2014 2Traverse Biosciences Executes Agreement with Aratana Therapeutics to Advance Development of TRB-N0224 for the Treatment and Control of Periodontal Disease in Pets 2Traverse Biosciences Executes Agreement with Aratana Therapeutics to Advance Development of TRB-N0224 for the Treatment and Control of Periodontal Disease in Pets 3Traverse Biosciences Executes Agreement with Aratana Therapeutics to Advance Development of TRB-N0224 for the Treatment and Control of Periodontal Disease in Pets 4Roger J Garceau joins Fluorinov board, adds clinical expertise to bromodomain program and oncology pipeline 2Roger J Garceau joins Fluorinov board, adds clinical expertise to bromodomain program and oncology pipeline 3Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 2Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 3
... , VANCOUVER , June 28 /PRNewswire-FirstCall/ - Dragon ... announced that its Special Meeting of Shareholders will be held on ... Time at the Company,s corporate office located at Suite 310, ... 4N9. Only shareholders of record of as of May 28, ...
... 28 Abviva, Inc. (OTC: ABVV), a biomedical company engaged ... Mammastatin, today announced they will be presenting at OneMedForum sponsored by ... 2010. Stifel was recently ranked #1 overall out of 183 qualifying ... on the Street Survey for 2010 . , ...
... ,, CHENNAI, India , June 28, 2010 ... an order worth USD 6 million from the private organizations and,Government ... Kenya , Tanzania and Ethiopia . The company will be ... , , ...
Cached Biology Technology:Dragon Pharma announces date of special meeting 2Abviva to Present at OneMedForum Sponsored by Stifel Nicolaus 2Indian Multinational Company Confirms USD 6 Million Order to Set up Industrial Waste Water Treatment Plants in Africa 2Indian Multinational Company Confirms USD 6 Million Order to Set up Industrial Waste Water Treatment Plants in Africa 3
... is designed to knockout or alter genes on ... one week. Red/ET recombination allows the exchange of ... and faithful manner. An FRT-flanked kanamycin resistance marker ... be used to replace a gene on the ...
... a state-of-the-art separation system using the asymmetric ... Eclipse integrates easily with Wyatts multi-angle light ... well as the Optilab DSP. The combined ... distributions of the particles/molecules separated by the ...
... to Rhodopsin Rhodopsin is a glycoprotein ... birds, amphibians, and reptiles. The rhodopsin protein ... the retina. Immunogen: Membrane ... Specificity: This antibody specifically labels the ...
... StabilCoat Immunoassay Stabilizer is an aqueous solution ... other non-toxic chemicals in a PBS buffer ... This product does not contain a ... conformation and activity of dried protein components ...
Biology Products: